Photon counting computed tomography (PC-CT) for Coronary Artery Disease

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Coronary Artery Disease
Photon counting computed tomography (PC-CT) - DiagnosticTest
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing whether PCD-CT provides more information about coronary artery disease than regular CT imaging.

Treatment Effectiveness

Study Objectives

1 Primary · 0 Secondary · Reporting Duration: Through completion of CT exam, approximately 1 day

Day 1
Disease

Trial Safety

Trial Design

2 Treatment Groups

Clinical Coronary CTA Cohort
1 of 2
Clinical Nuclear Medicine or MRI Cardiac Stress Test Cohort
1 of 2

Experimental Treatment

450 Total Participants · 2 Treatment Groups

Primary Treatment: Photon counting computed tomography (PC-CT) · No Placebo Group · N/A

Clinical Coronary CTA Cohort
DiagnosticTest
Experimental Group · 1 Intervention: Photon counting computed tomography (PC-CT) · Intervention Types: DiagnosticTest
Clinical Nuclear Medicine or MRI Cardiac Stress Test Cohort
DiagnosticTest
Experimental Group · 1 Intervention: Photon counting computed tomography (PC-CT) · Intervention Types: DiagnosticTest

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: through completion of ct exam, approximately 1 day

Who is running the clinical trial?

National Institute for Biomedical Imaging and Bioengineering (NIBIB)NIH
78 Previous Clinical Trials
17,303 Total Patients Enrolled
2 Trials studying Coronary Artery Disease
338 Patients Enrolled for Coronary Artery Disease
Mayo ClinicLead Sponsor
2,893 Previous Clinical Trials
3,698,216 Total Patients Enrolled
27 Trials studying Coronary Artery Disease
26,685 Patients Enrolled for Coronary Artery Disease
Cynthia McCollough, PhDPrincipal InvestigatorMayo Clinic

Eligibility Criteria

Age 18+ · All Participants · 3 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You are able and willing to sign the informed consent.
Patients referred for cardiac CT imaging or nuclear medicine or MRI cardiac perfusion within the Department of Radiology or Cardiology.
A negative pregnancy test if the subject is of child-bearing age.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 19th, 2021

Last Reviewed: November 7th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.