PC-CT Imaging for Coronary Artery Disease
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, if you are participating in the cardiac stress test part of the study, you should avoid caffeine and certain medications that might interact with the stress test drug.
What data supports the effectiveness of the treatment Photon counting computed tomography (PC-CT) for coronary artery disease?
Photon counting computed tomography (PC-CT) is a new technology that shows promise in improving heart imaging by providing clearer images with less noise and lower radiation exposure. It can help doctors better detect and evaluate heart conditions like coronary artery calcifications and plaque, which are important for diagnosing coronary artery disease.12345
Is photon-counting computed tomography (PC-CT) safe for humans?
How is photon counting computed tomography (PC-CT) different from other treatments for coronary artery disease?
Photon counting computed tomography (PC-CT) is unique because it offers improved image quality with better spatial resolution and contrast, reduced radiation exposure, and the ability to differentiate materials more effectively than conventional CT scans. This makes it particularly useful for accurately assessing coronary artery conditions, such as plaque buildup and stent evaluation, which are challenging with traditional methods.12347
What is the purpose of this trial?
The purpose of this research trial is to determine whether images taken using a Photon Counting Detector CT scanner (PCD-CT) after the patient has received a drug that makes the heart work harder provide clinically important information about the severity of suspected coronary artery disease compared to CT imaging performed without using the drug that causes the heart to work harder.
Research Team
Cynthia McCollough, PhD
Principal Investigator
Mayo Clinic
Eligibility Criteria
This trial is for patients who need a coronary artery cardiac CT scan and can consent to the study. They should not be pregnant, have severe kidney issues (eGFR ≤ 30), or known allergies to certain heart stress test drugs. It's not for hospitalized patients, those with serious heart rhythm problems, recent seizures, severe asthma/COPD, or a bad reaction to contrast dye before.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Imaging
Participants undergo a photon-counting CT scan with and without a cardiac stress agent
Follow-up
Participants are monitored for safety and effectiveness after imaging
Treatment Details
Interventions
- Photon counting computed tomography (PC-CT)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
National Institute for Biomedical Imaging and Bioengineering (NIBIB)
Collaborator