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Device

CPAP + Niacin for Sleep Apnea and Prediabetes

N/A
Recruiting
Led By Esra Tasali, MD
Research Sponsored by University of Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Prediabetic
Sleep apnea
Timeline
Screening 3 weeks
Treatment Varies
Follow Up niacin, within 4 months of screening
Awards & highlights

Study Summary

This trial will study how sleep apnea affects diabetes.

Who is the study for?
This trial is for individuals who are prediabetic, have sleep apnea, and are overweight or obese. It's not open to those with diabetes, severe high blood pressure, bleeding disorders, pregnant or nursing women, anyone with a life-limiting disease or on medications that could affect the study results.Check my eligibility
What is being tested?
The study is testing whether Niacin (a vitamin) and Continuous Positive Airway Pressure (CPAP), which helps keep airways open during sleep, can prevent diabetes in people with sleep apnea.See study design
What are the potential side effects?
Niacin may cause flushing of the skin, itching or rash; CPAP might lead to discomfort at the mask site, dry nose or throat. Side effects vary from person to person.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am prediabetic.
Select...
I have been diagnosed with sleep apnea.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~niacin, within 4 months of screening
This trial's timeline: 3 weeks for screening, Varies for treatment, and niacin, within 4 months of screening for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Plasma norepinephrine levels

Trial Design

3Treatment groups
Active Control
Group I: NiacinActive Control1 Intervention
Untreated, pharmacological suppression of lipolysis by Niacin
Group II: Continuous positive airway pressure (CPAP) treatmentActive Control1 Intervention
Continuous positive airway pressure (CPAP) treatment
Group III: UntreatedActive Control1 Intervention
Untreated condition (obstructive sleep apnea)

Find a Location

Who is running the clinical trial?

University of ChicagoLead Sponsor
1,004 Previous Clinical Trials
819,477 Total Patients Enrolled
2 Trials studying Sleep Apnea
779 Patients Enrolled for Sleep Apnea
Mayo ClinicOTHER
3,213 Previous Clinical Trials
3,766,711 Total Patients Enrolled
4 Trials studying Sleep Apnea
1,479 Patients Enrolled for Sleep Apnea
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,838 Previous Clinical Trials
47,851,354 Total Patients Enrolled
15 Trials studying Sleep Apnea
5,258 Patients Enrolled for Sleep Apnea

Media Library

Continuous positive airway pressure (Device) Clinical Trial Eligibility Overview. Trial Name: NCT04234217 — N/A
Sleep Apnea Research Study Groups: Niacin, Continuous positive airway pressure (CPAP) treatment, Untreated
Sleep Apnea Clinical Trial 2023: Continuous positive airway pressure Highlights & Side Effects. Trial Name: NCT04234217 — N/A
Continuous positive airway pressure (Device) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04234217 — N/A
Sleep Apnea Patient Testimony for trial: Trial Name: NCT04234217 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals currently enrolling in this clinical trial?

"As indicated by clinicaltrials.gov, this research initiative is open and actively seeking individuals to participate. It was first advertised on November 26th 2019 and the most recent update took place on April 13th 2022."

Answered by AI

Who qualifies to be a participant in this investigation?

"This medical research is seeking 300 individuals with sleep apnea between the ages of 20 and 65. Essential qualifications for enrolment include: being overweight or obese, plus a confirmed case of sleep apnea."

Answered by AI

Does this experimental trial accept elderly individuals as participants?

"According to the trial's guidelines, potential participants must be between 20 and 65 years old."

Answered by AI

How many participants are currently partaking in the research?

"Affirmative. According to clinicaltrials.gov, this trial which commenced on November 26th 2019 is actively recruiting patients. 300 individuals need to be signed up at one medical centre."

Answered by AI

Who else is applying?

What state do they live in?
Michigan
Indiana
Illinois
How old are they?
65+
What site did they apply to?
University of Chicago
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
1

Why did patients apply to this trial?

Trying to get A1C down - been trying with diet and exercise. I’ve had sleep apnea for 10+ years. Previously I used a CPAP before the recalls. Since then.
PatientReceived 1 prior treatment
Recent research and studies
clinicaltrials.govStudy
Mechanisms of Prediabetic States in Sleep Apnea
2019. "Mechanisms of Prediabetic States in Sleep Apnea". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04234217.
All > Prediabetes > Sleep Apnea
~63 spots leftby Jul 2025
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