PAD Clinical Trials 2023

What Are PAD Clinical Trials?

PAD is more commonly known as Peripheral Artery Disease. This disease causes reduced blood flow due to narrow arteries in the arms and legs. However, it primarily affects the legs. The reduced blood flow causes leg pain when walking and other negative symptoms.

You can manage this disease by exercising and maintaining a healthy diet. Unfortunately, tobacco products also play a role in this disease, so patients who suffer from it should avoid smoking. Clinical trials for this disease can also include new medications or new forms of treatment to help patients manage this disease. For example, some clinical trials study the efficiency of exercise methods to help with blood flow.

Why Is PAD Being Studied Through Clinical Trials?

While some people with the condition can have mild to no symptoms, others can suffer from the pain and discomfort the disease causes. The pain this disease causes is most often on the calf of the leg, and people may struggle to walk as a result. Clinical trials help medical professionals discover new ways to treat or even cure this disease.

Leg, foot, and toe wounds do not always heal properly, causing further issues. Some other symptoms are a weak or absent pulse, tingling or numbness in the leg, and a feeling of coldness in the lower leg. Peripheral Artery Disease (PAD) is caused by cholesterol deposits on the arterial walls, which are exacerbated by obesity. In addition to the visual manifestation of skin color changes, hip discomfort is another common symptom of this condition.

Approximately 8 million people suffer from PAD in the United States. Most of them are over 40, and the disease also occurs mainly in men. Women also develop the disease later than men in their 60s and 70s. Risk factors of the disease also include obesity, high cholesterol, and high blood pressure.

What Are The Types Of Treatments Available For PAD?

One of the clinical trials available for PAD is Angiotensin 1-7. This trial tests whether a new hormone will improve PAD disease. They hope the treatment enhances the patient's blood vessel function and reduces inflammation.

Another example of a clinical trial available is MyPADMGT. This clinical trial is not a new medication but an online program for patients with PED. The online program will help the patients better manage the disease by themselves.

What Are Some Recent Breakthrough Clinical Trials For PAD?

2017 – Exercise training - In this clinical trial, they studied the effect of specific exercises on patients with PED. They supervised patients while they exercised on a treadmill for a 180-meter walk. They concluded that the treadmill walk increased the health of patients with the disease.

2018 – Invasive treatment - In this clinical trial, they studied the effects of specific invasive therapies on patients suffering from PAD. Invasive treatment has become an alternative to surgical therapy in PAD. In addition, treatment can include medication, surgery, or endovascular management. However, further research shows that each side of this disease has unique characteristics.

Who Are Some Of The Key Researchers Conducting PAD Clinical Trial Research?

Bijan Modarai is a researcher in vascular surgery at the British Heart Foundation. He has a Ph.D. in Biochemistry which he received in 2006. In addition, he also completed his basic training in London. Professor Bijan has multiple publications and was rewarded a Hunterian Professorship in 2017 from The Royal College of Surgeons.

Karen L. Andrews is the director of the Vascular Ulcer/Wound Healing Clinic. She is an associate professor at the Mayo Clinical and Chair of the Amputee Rehabilitation Service, teaches at the Mayo school, and mentors individuals. She completed her residency at the University of Michigan in 1989.