CT Angiography for Peripheral Arterial Disease
(CAD in sPAD Trial)
Trial Summary
Do I need to stop my current medications to join the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Coronary computed tomography (CT) angiography with FFR-CT for Peripheral Arterial Disease?
Research shows that CT angiography with FFR-CT is effective in assessing coronary artery disease by providing detailed images and functional information, helping doctors make better treatment decisions. This suggests it could be useful for evaluating other artery-related conditions like Peripheral Arterial Disease.12345
Is CT angiography generally safe for humans?
How is CT angiography with FFR-CT different from other treatments for peripheral arterial disease?
CT angiography with FFR-CT is unique because it uses advanced imaging technology to provide detailed pictures of blood vessels, helping doctors plan and monitor treatments for peripheral arterial disease. This approach is faster and offers better image quality compared to traditional methods, making it a valuable tool for diagnosing and planning endovascular procedures.611121314
What is the purpose of this trial?
Peripheral artery disease, lack or blood flow to the legs, has a high prevalence in the Veteran population. In patients with severe peripheral artery disease that requires an endovascular or surgical intervention for lower leg revascularization, the long-term mortality of approximately 50% is worse that most cancers. The goal of this study is to develop a management strategy to improve cardiovascular outcomes in this high-risk peripheral artery disease population after lower extremity revascularization.
Research Team
Clay Quint, MD PhD
Principal Investigator
Rocky Mountain Regional VA Medical Center, Aurora, CO
Eligibility Criteria
This trial is for veterans with severe peripheral artery disease (PAD) who have undergone surgery or endovascular intervention to restore blood flow in their legs. Participants should be at high risk of cardiovascular issues post-revascularization.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a coronary CTA with FFR-CT and selective coronary artery revascularization plus optimal medical therapy
Follow-up
Participants are monitored for major adverse cardiovascular events, myocardial infarction, all-cause mortality, and amputation-free survival
Treatment Details
Interventions
- Coronary computed topography (CT) angiography with FFR-CT
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor