Radiation for human papillomavirus
Phase-Based Progress Estimates
Effectiveness
Safety
Memorial Sloan Kettering Cancer Center at Suffolk-Commack (Limited Protocol Activities), Commack, NY
human papillomavirus+7 More
Radiation - RadiationEligibility
18+
All Sexes
What conditions do you have?
Select
Eligibility
18+
All Sexes
What conditions do you have?
Select
Study Summary
The purpose of this study is to find out if lower doses of radiation may help reduce the side effects of radiation therapy in combination with standard-of-care chemotherapy in people with HPV-positive throat cancer. The chemotherapy drugs used in this study include cisplatin, carboplatin, and 5-fluorouracil (5- FU).
Eligible Conditions
- HPV
- human papillomavirus
- Oropharyngeal Carcinoma
- Oropharyngeal Cancers
- Throat Cancer
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 0 Secondary · Reporting Duration: 2 years
2 years
Number of participants with any locoregional recurrences
Trial Safety
Safety Progress
This is further along than 68% of similar trials
Trial Design
1 Treatment Group
Participants with HPV-Positive Throat Cancer
1 of 1
Experimental Treatment
71 Total Participants · 1 Treatment Group
Primary Treatment: Radiation · No Placebo Group · Phase 2
Participants with HPV-Positive Throat CancerExperimental Group · 5 Interventions: Carboplatin, 18 F-FMISO PET/CT, Radiation, Cisplatin, 5-fluorouracil · Intervention Types: Drug, DiagnosticTest, Radiation, Drug, Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Carboplatin
2014
Completed Phase 3
~6570
Radiation
2005
Completed Phase 3
~990
Cisplatin
2013
Completed Phase 3
~3340
5-fluorouracil
2005
Completed Phase 4
~7820
Trial Logistics
Trial Timeline
Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 2 years
Closest Location: Memorial Sloan Kettering Cancer Center at Suffolk-Commack (Limited Protocol Activities) · Commack, NY
N/AFirst Recorded Clinical Trial
0 TrialsResearching human papillomavirus
0 CompletedClinical Trials
Who is running the clinical trial?
Memorial Sloan Kettering Cancer CenterLead Sponsor
1,806 Previous Clinical Trials
589,257 Total Patients Enrolled
Nancy Lee, MDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center
10 Previous Clinical Trials
1,288 Total Patients Enrolled
Eligibility Criteria
Age 18+ · All Participants · 10 Total Inclusion Criteria
Mark “yes” if the following statements are true for you:Subjects must have clinically or radiographically evident measurable gross disease at either the primary tumor site or nodal stations.
A primary squamous cell carcinoma of the neck of unknown primary is allowed with excision biopsy of a lymph node (or core biopsy) or consent from the PI or co-PI.
You have a CT or PET/CT scan of the neck with and without contrast.
You have a performance status of 0-2 or KPS ≥ 50.
You have a white blood count (WBC) of 2,000 or more per microliter (μl).
The absolute neutrophil count (ANC) is ≥ 1,000 cells/mm3.
You have a platelet count of at least 100,000 cells/mm3.
About The Reviewer
Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.
Top Oncology Trials
Top Clinical Trials in Cities
Relevant Clinical Trials
Unbiased Results
We believe in providing patients with all the options.Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.Back to top
Conditions
Cancer Related
Treatments