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Liquid Biopsy

Liquid Biopsy for Lung Cancer

N/A
Recruiting
Led By Dan Raz
Research Sponsored by City of Hope Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Smoking history of >= 20 pack-years and if quit, quit within 15 years.
Consent to undergo lung cancer screening with either liquid biopsy (LB) or LDCT.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 6 months
Awards & highlights

Study Summary

This trial is testing how well cell-free DNA liquid biopsy works in screening high-risk patients for lung cancer.

Who is the study for?
This trial is for English-speaking individuals aged 50-80 who are at high risk for lung cancer due to a smoking history of 20 or more pack-years and, if they've quit, it was within the last 15 years. They must consent to screening with liquid biopsy or CT scan and have insurance covering LDCT at specified centers. Excluded are those with any recent cancer diagnosis (except non-melanoma skin cancer) or symptoms of lung cancer.Check my eligibility
What is being tested?
The study is testing the practicality of using cell-free DNA liquid biopsies for early detection of lung cancer in high-risk patients compared to low dose CT scans. It aims to see if positive results from liquid biopsies encourage patients to follow up with CT scans, potentially increasing early detection rates.See study design
What are the potential side effects?
There may be minimal side effects associated with providing a blood sample for the liquid biopsy. The low dose CT scan involves exposure to a small amount of radiation but generally has few immediate side effects.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You have smoked for at least 20 years, and if you quit, it was within the last 15 years.
Select...
You agree to have either a liquid biopsy or low-dose CT scan to screen for lung cancer.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Screening preference
Secondary outcome measures
Participants who follow-through on screening 1
Participants who follow-through on screening 2
Participants who follow-through on screening 3
+8 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Cohort B (LDCT, optional liquid biopsy)Experimental Treatment3 Interventions
Participants undergo low dose CT with optional liquid biopsy on the same day as LDCT.
Group II: Cohort A (liquid biopsy, optional LDCT)Experimental Treatment3 Interventions
Participants undergo collection of blood sample (liquid biopsy), with option to undergo LDCT if liquid biopsy results are positive.

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)NIH
13,621 Previous Clinical Trials
40,927,314 Total Patients Enrolled
City of Hope Medical CenterLead Sponsor
560 Previous Clinical Trials
1,918,044 Total Patients Enrolled
Dan RazPrincipal InvestigatorCity of Hope Medical Center
3 Previous Clinical Trials
502 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Am I a suitable candidate to participate in this research?

"This clinical trial seeks 100 participants diagnosed with lung cancer, aged between 50 and 80. In order to qualify for the study, patients must have a documented written informed consent, smoking history of at least 20 pack-years (or quit within 15 years), be referred for counseling regarding Lung Cancer Screening Tests that their health insurance can cover, agree to provide blood samples in English language and sign off on undergoing either Liquid Biopsy or LDCT screening."

Answered by AI

Does the enrollment criteria for this trial encompass individuals aged 45 and above?

"This research initiative is recruiting participants over the age of 50 and below 80 years old."

Answered by AI

How many volunteers are eligible to be part of this experiment?

"Affirmative. Per the info hosted on clinicaltrials.gov, this medical research is actively seeking participants with a goal of recruiting 100 patients from 1 location. The study was initially published on July 29th 2022 and its most recent update came August 15th 2022."

Answered by AI

Are individuals still able to partake in this experimentation?

"Affirmative. According to the clinicaltrials.gov listing, this medical trial is actively recruiting. It was posted on July 29th 2022 and has been edited as recently as August 15th of the same year. The study needs 100 participants from 1 site in order to complete enrolment."

Answered by AI
~55 spots leftby Jan 2026