Exposure and Response Prevention for Obsessive-Compulsive Disorder
Trial Summary
What is the purpose of this trial?
This trial will test a therapy called ERP, which helps people face their fears and stop doing habits that make them feel temporarily better but keep the problem going. It will focus on Veterans with OCD, including those who also have PTSD. The goal is to see if this therapy improves their daily functioning and quality of life.
Will I have to stop taking my current medications?
If you are taking psychotropic medications, you need to be on a stable dose for at least 6 weeks before joining the study. This means you don't have to stop your current medications, but they should not be changed right before or during the trial.
What data supports the effectiveness of the treatment Exposure and Response Prevention for Obsessive-Compulsive Disorder?
Research shows that Exposure and Response Prevention (ERP) is the most effective treatment for obsessive-compulsive disorder (OCD), with about 90% of patients who undergo ERP experiencing significant improvements. ERP is also effective in reducing symptoms in related conditions like Tourette syndrome.12345
Is exposure and response prevention (ERP) therapy safe for humans?
Some therapists have concerns about the safety of ERP, especially for certain types of OCD symptoms, but there is no strong evidence of serious negative consequences. ERP is generally considered safe, though it can be distressing for some people, which may lead to them stopping treatment early.26789
How is the treatment Exposure and Response Prevention (ERP) unique for obsessive-compulsive disorder (OCD)?
Exposure and Response Prevention (ERP) is unique because it involves gradually facing fears and resisting the urge to perform compulsive behaviors, which is different from medication-based treatments. It is the most supported psychological treatment for OCD and can be used alone or with cognitive therapy to potentially enhance its effectiveness.123810
Research Team
Terri L. Fletcher, PhD
Principal Investigator
Michael E. DeBakey VA Medical Center, Houston, TX
Eligibility Criteria
This trial is for Veterans diagnosed with OCD, and half of the participants will also have PTSD. They must be receiving care from specific VA medical centers or via telehealth in certain states and willing to undergo ERP therapy. Those with severe cognitive issues, psychosis, mania, high suicide risk, or substance abuse problems cannot join.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive 16 weekly sessions of ERP or stress management training via VTH
Post-Treatment Assessment
Participants complete assessments to evaluate treatment outcomes
Follow-up
Participants are monitored for safety and effectiveness 6 months after treatment
Treatment Details
Interventions
- Exposure and Response Prevention
Exposure and Response Prevention is already approved in United States, European Union, Canada for the following indications:
- Obsessive-Compulsive Disorder (OCD)
- Obsessive-Compulsive Disorder (OCD)
- Obsessive-Compulsive Disorder (OCD)
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor