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Aerobic Exercise + Virtual Reality for Parkinson's Disease

Research Sponsored by The University of Texas Health Science Center at San Antonio
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Diagnosis of idiopathic PD (ages 18 - 85) in Hoehn and Yahr stages 1 - 3
Be older than 18 years old
Screening 3 weeks
Treatment Varies
Follow Up baseline to 3 weeks
Awards & highlights

Study Summary

This trial will test the feasibility and effects of exercise and VR on motor behavior and neuroplasticity in PD patients. If successful, this could provide new insight into using AE and VR to improve cognition, gait, and neuroplasticity in PD patients.

Who is the study for?
This trial is for people aged 18-85 with Parkinson's Disease in early to mid-stages (stages 1-3) who can think clearly enough (score ≥23 on a mental state exam). It's not for those with other neurological diseases, severe heart/lung conditions, uncontrolled diabetes or blood pressure issues, severe bone weakness, brain surgery for PD, head injuries, seizures/epilepsy, pregnancy or certain medication use.Check my eligibility
What is being tested?
The study tests how aerobic exercise combined with virtual reality affects movement and brain changes in Parkinson's. Participants will do physical exercises while engaging in VR tasks to see if this improves their motor skills and cognitive functions.See study design
What are the potential side effects?
Potential side effects may include fatigue from the exercise and possible discomfort or dizziness from using virtual reality equipment. Since it involves physical activity and technology use, there might be risks of falls or motion sickness.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I have Parkinson's disease, aged 18-85, in early to mid-stages.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to 3 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 3 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Corticomotor excitability
+2 more
Secondary outcome measures
Quality of Life Survey

Trial Design

1Treatment groups
Experimental Treatment
Group I: Combined Aerobic Exercise (AE) and Virtual Reality (VR)-based programExperimental Treatment2 Interventions
Individuals diagnosed with PD will participate in AE and VR.
First Studied
Drug Approval Stage
How many patients have taken this drug
Virtual Reality
Completed Phase 3

Find a Location

Who is running the clinical trial?

The University of Texas Health Science Center at San AntonioLead Sponsor
457 Previous Clinical Trials
91,576 Total Patients Enrolled
Texas Physical Therapy AssociationOTHER
5 Previous Clinical Trials
169 Total Patients Enrolled

Media Library

Aerobic Exercise Clinical Trial Eligibility Overview. Trial Name: NCT05385497 — N/A
Parkinson's Disease Research Study Groups: Combined Aerobic Exercise (AE) and Virtual Reality (VR)-based program
Parkinson's Disease Clinical Trial 2023: Aerobic Exercise Highlights & Side Effects. Trial Name: NCT05385497 — N/A
Aerobic Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT05385497 — N/A
~8 spots leftby Apr 2025