Uloric

chronic, symptomatic Hyperuricemia, Arthritis, Gouty, allopurinol

Treatment

3 FDA approvals

4 Active Studies for Uloric

Treatment for

chronic, symptomatic Hyperuricemia

What is Uloric

FebuxostatThe Generic name of this drug

Treatment SummaryFebuxostat is a medication used to treat high levels of uric acid in the blood that can cause gout. Gout is a type of arthritis caused by the buildup of uric acid crystals in or around a joint, causing inflammation and long-term damage to bones, tissues, and other organs. Febuxostat works by blocking an enzyme responsible for the production of uric acid, which helps to lower the amount of uric acid in the blood. In 2019, the FDA added a black box warning to febuxostat due to an increased risk of cardiovascular-related death in patients with existing cardiovascular disease when

Uloricis the brand name

image of different drug pills on a surface

Uloric Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Uloric

Febuxostat

2009

Approved as Treatment by the FDA

Febuxostat, also known as Uloric, is approved by the FDA for 3 uses which include Arthritis, Gouty and allopurinol .

Arthritis, Gouty

Helps manage Gouty Arthritis

allopurinol

Helps manage inadequate response to or intolerant of allopurinol

chronic, symptomatic Hyperuricemia

Helps manage chronic, symptomatic Hyperuricemia

Effectiveness

How Uloric Affects PatientsFebuxostat is a medication that helps to lower levels of uric acid in the body. When taken daily in doses of 40-80 mg, it can reduce the 24-hour mean serum uric acid concentrations by 40-55%. This drug is different from allopurinol and oxypurinol as it does not affect other enzymes related to the production of purines and pyrimidines in the body. Taking febuxostat may cause gout flares.

How Uloric works in the bodyGout is a type of arthritis caused by uric acid crystals forming around the joints. Febuxostat helps treat gout by blocking an enzyme called XOR. This enzyme helps make uric acid which causes gout. In some cases, XOR can also be converted into a form which produces harmful chemicals called reactive oxygen species. Febuxostat helps block the conversion of XOR, reducing the amount of reactive oxygen species produced and decreasing inflammation. In some cases, febuxostat has also been shown to reduce oxidative stress and renal injury in a rat model.

When to interrupt dosage

The suggested measure of Uloric is contingent upon the diagnosed disorder, such as chronic, symptomatic Hyperuricemia, Gouty Arthritis and allopurinol. The quantity of dosage varies, in accordance with the administration technique (e.g. Oral or Tablet, coated) specified in the table beneath.

Condition

Dosage

Administration

chronic, symptomatic Hyperuricemia

80.0 mg, , 40.0 mg, 120.0 mg

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated - Oral, Tablet, coated

Arthritis, Gouty

80.0 mg, , 40.0 mg, 120.0 mg

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated - Oral, Tablet, coated

allopurinol

80.0 mg, , 40.0 mg, 120.0 mg

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated - Oral, Tablet, coated

Warnings

Uloric Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Uloric.

Common Uloric Drug Interactions

Drug Name

Risk Level

Description

Azathioprine

Major

The metabolism of Azathioprine can be decreased when combined with Febuxostat.

Didanosine

Major

The serum concentration of Didanosine can be increased when it is combined with Febuxostat.

Mercaptopurine

Major

The serum concentration of Mercaptopurine can be increased when it is combined with Febuxostat.

Ozanimod

Major

Febuxostat may decrease the excretion rate of Ozanimod which could result in a higher serum level.

Pegloticase

Major

The risk or severity of adverse effects can be increased when Febuxostat is combined with Pegloticase.

Uloric Toxicity & Overdose RiskThe most toxic dose of febuxostat that has been reported in humans is 1.82mg/kg taken over a 14 day period. In mice, the toxic dose is 300mg/kg, 3200mg/kg in rabbits, and 980mg/kg in rats. No serious side effects were observed in healthy people who took up to 300mg of febuxostat per day for 7 days. If someone takes too much febuxostat, there is no known antidote and they should just be given supportive care.

image of a doctor in a lab doing drug, clinical research

Uloric Novel Uses: Which Conditions Have a Clinical Trial Featuring Uloric?

At present, 0 active clinical trials are examining the potential of Uloric to ameliorate allopurinol, chronic symptomatic Hyperuricemia and Gouty Arthritis.

Condition

Clinical Trials

Trial Phases

allopurinol

0 Actively Recruiting

chronic, symptomatic Hyperuricemia

0 Actively Recruiting

Arthritis, Gouty

4 Actively Recruiting

Phase 2, Phase 3, Not Applicable

Uloric Reviews: What are patients saying about Uloric?

5Patient Review

2/9/2016

Uloric for Treatment to Prevent Gout

I've been dealing with gout since I was 28, and it's been a real pain (literally). I was initially put on Allupurinol, but the side effects were so bad that I had to switch to Uloric. It's much more expensive, but it's worth it because I actually feel like a normal person again.

5Patient Review

1/17/2016

Uloric for Gout

Since I started taking Uloric, I haven't had a single gout attack. This medication is very expensive, but it has been worth it for me.

5Patient Review

10/31/2016

Uloric for Treatment to Prevent Gout

Uloric has been a miracle drug for me. It's nice to be able to walk again without pain. My uric acid levels are now under control and I haven't had any gout attacks since regular use of the medication.

5Patient Review

4/29/2017

Uloric for Gout

This medication was a literal lifesaver. I had to take the 80mg dosage to clear it out of my system quicker, and it worked like a charm. I used to have at least three flare-ups per year, and they were absolutely horrible. I'm so grateful that this medication has allowed me to go eight years without a single one.

5Patient Review

11/29/2016

Uloric for Gout

I've been using this for approximately a year now (40 mg daily) and have found it to be highly effective in preventing future attacks. I used to experience an attack every three or four months, but since being on this medication, that's no longer the case. I'm also able to eat whatever I want without triggering an attack (in moderation, of course). If you're considering this drug, know that it may not work for everyone – but it did wonders for me.

View All Reviews

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about uloric

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Uloric used for?

"Febuxostat is a drug that lowers uric acid levels in people who have gout. It works by reducing the amount of uric acid that the body produces. High levels of uric acid can cause gout."

Answered by AI

Is Uloric better than allopurinol?

"Takeda's clinical trials found that 80mg and 40mg doses of Uloric worked better and at least as well as allopurinol, respectively. Uloric is excreted much less through urine than allopurinol, making it a safer option for patients with kidney problems."

Answered by AI

Should I take Uloric during a gout attack?

"Uloric was a first-line treatment for gout in adults for almost 10 years, but in 2019 the U.S. Food and Drug Administration concluded that the drug presents a higher risk of death than a competing medicine and should not be used as the first choice for gout treatment."

Answered by AI