Uloric

chronic, symptomatic Hyperuricemia, Gouty Arthritis, allopurinol
Treatment
3 FDA approvals
1 Active Study for Uloric

What is Uloric

FebuxostatThe Generic name of this drug
Treatment SummaryFebuxostat is a medication used to treat high levels of uric acid in the blood that can cause gout. Gout is a type of arthritis caused by the buildup of uric acid crystals in or around a joint, causing inflammation and long-term damage to bones, tissues, and other organs. Febuxostat works by blocking an enzyme responsible for the production of uric acid, which helps to lower the amount of uric acid in the blood. In 2019, the FDA added a black box warning to febuxostat due to an increased risk of cardiovascular-related death in patients with existing cardiovascular disease when
Uloricis the brand name
image of different drug pills on a surface
Uloric Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Uloric
Febuxostat
2009
51

Approved as Treatment by the FDA

Febuxostat, also known as Uloric, is approved by the FDA for 3 uses which include Gouty Arthritis and chronic, symptomatic Hyperuricemia .
Gouty Arthritis
Helps manage Gouty Arthritis
chronic, symptomatic Hyperuricemia
Helps manage chronic, symptomatic Hyperuricemia
allopurinol
Helps manage inadequate response to or intolerant of allopurinol

Effectiveness

How Uloric Affects PatientsFebuxostat is a medication that helps to lower levels of uric acid in the body. When taken daily in doses of 40-80 mg, it can reduce the 24-hour mean serum uric acid concentrations by 40-55%. This drug is different from allopurinol and oxypurinol as it does not affect other enzymes related to the production of purines and pyrimidines in the body. Taking febuxostat may cause gout flares.
How Uloric works in the bodyGout is a type of arthritis caused by uric acid crystals forming around the joints. Febuxostat helps treat gout by blocking an enzyme called XOR. This enzyme helps make uric acid which causes gout. In some cases, XOR can also be converted into a form which produces harmful chemicals called reactive oxygen species. Febuxostat helps block the conversion of XOR, reducing the amount of reactive oxygen species produced and decreasing inflammation. In some cases, febuxostat has also been shown to reduce oxidative stress and renal injury in a rat model.

When to interrupt dosage

The suggested measure of Uloric is contingent upon the diagnosed disorder, such as chronic, symptomatic Hyperuricemia, Gouty Arthritis and allopurinol. The quantity of dosage varies, in accordance with the administration technique (e.g. Oral or Tablet, coated) specified in the table beneath.
Condition
Dosage
Administration
chronic, symptomatic Hyperuricemia
80.0 mg, , 40.0 mg, 120.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated - Oral, Tablet, coated
allopurinol
80.0 mg, , 40.0 mg, 120.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated - Oral, Tablet, coated
Gouty Arthritis
80.0 mg, , 40.0 mg, 120.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated - Oral, Tablet, coated

Warnings

Uloric Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Uloric.
Common Uloric Drug Interactions
Drug Name
Risk Level
Description
Azathioprine
Major
The metabolism of Azathioprine can be decreased when combined with Febuxostat.
Didanosine
Major
The serum concentration of Didanosine can be increased when it is combined with Febuxostat.
Mercaptopurine
Major
The serum concentration of Mercaptopurine can be increased when it is combined with Febuxostat.
Ozanimod
Major
Febuxostat may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Pegloticase
Major
The risk or severity of adverse effects can be increased when Febuxostat is combined with Pegloticase.
Uloric Toxicity & Overdose RiskThe most toxic dose of febuxostat that has been reported in humans is 1.82mg/kg taken over a 14 day period. In mice, the toxic dose is 300mg/kg, 3200mg/kg in rabbits, and 980mg/kg in rats. No serious side effects were observed in healthy people who took up to 300mg of febuxostat per day for 7 days. If someone takes too much febuxostat, there is no known antidote and they should just be given supportive care.
image of a doctor in a lab doing drug, clinical research

Uloric Novel Uses: Which Conditions Have a Clinical Trial Featuring Uloric?

At present, 0 active clinical trials are examining the potential of Uloric to ameliorate allopurinol, chronic symptomatic Hyperuricemia and Gouty Arthritis.
Condition
Clinical Trials
Trial Phases
allopurinol
0 Actively Recruiting
Gouty Arthritis
1 Actively Recruiting
Phase 2, Phase 3
chronic, symptomatic Hyperuricemia
0 Actively Recruiting

Uloric Reviews: What are patients saying about Uloric?

5Patient Review
2/9/2016
Uloric for Treatment to Prevent Gout
I've been dealing with gout since I was 28, and it's been a real pain (literally). I was initially put on Allupurinol, but the side effects were so bad that I had to switch to Uloric. It's much more expensive, but it's worth it because I actually feel like a normal person again.
5Patient Review
1/17/2016
Uloric for Gout
Since I started taking Uloric, I haven't had a single gout attack. This medication is very expensive, but it has been worth it for me.
5Patient Review
10/31/2016
Uloric for Treatment to Prevent Gout
Uloric has been a miracle drug for me. It's nice to be able to walk again without pain. My uric acid levels are now under control and I haven't had any gout attacks since regular use of the medication.
5Patient Review
4/29/2017
Uloric for Gout
This medication was a literal lifesaver. I had to take the 80mg dosage to clear it out of my system quicker, and it worked like a charm. I used to have at least three flare-ups per year, and they were absolutely horrible. I'm so grateful that this medication has allowed me to go eight years without a single one.
5Patient Review
11/29/2016
Uloric for Gout
I've been using this for approximately a year now (40 mg daily) and have found it to be highly effective in preventing future attacks. I used to experience an attack every three or four months, but since being on this medication, that's no longer the case. I'm also able to eat whatever I want without triggering an attack (in moderation, of course). If you're considering this drug, know that it may not work for everyone – but it did wonders for me.
5Patient Review
3/15/2016
Uloric for Gout
Uloric has been a life-saving medication for me. After 25 years of debilitating gout, it has reversed my trophies in just two years. I feel like a miracle!
5Patient Review
11/21/2019
Uloric for Gout
Uloric was fantastic, but the new generic that just came out didn't work at all for me. I had my first gout attack in four years after 30 days of taking the new generic. The FDA needs to do a better job of certifying these generics.
5Patient Review
10/12/2021
Uloric for Treatment to Prevent Gout
After trying this medication for two years, I was able to successfully wean myself off of it. My doctor suggested tapering down the dosage over the course of a year until I was completely off, and that worked well for me. Just be mindful of your diet after getting off the medication.
5Patient Review
10/16/2018
Uloric for Gout
Uloric took a little bit of time to start working, but it was well worth the wait. I haven't had an attack in years and only need a quarter pill each day.
5Patient Review
11/3/2014
Uloric for Gout
3Patient Review
5/6/2017
Uloric for Treatment to Prevent Gout
I tried Allopurinol and Colchicine before this with terrible side effects, so I thought Uloric would be an improvement. Unfortunately, I'm still having flares plus it's causing my hair to fall out. Needless to say, I'll be discontinuing use of this medication.
1.3Patient Review
10/27/2015
Uloric for Gout
I was placed on 40 mg Uloric, and when that didn't work after a month, my doctor increased the dosage to 80 mg. Unfortunately, there was no change in my condition.
1.3Patient Review
4/6/2015
Uloric for Gout
Unfortunately, this medication made me very ill and caused a severe gout flare-up.
1Patient Review
2/2/2015
Uloric for Gout
Uloric has really helped me a lot. I haven't had gout in four years and the tophi on my elbow and knuckles have disappeared.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about uloric

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Uloric used for?

"Febuxostat is a drug that lowers uric acid levels in people who have gout. It works by reducing the amount of uric acid that the body produces. High levels of uric acid can cause gout."

Answered by AI

Is Uloric better than allopurinol?

"Takeda's clinical trials found that 80mg and 40mg doses of Uloric worked better and at least as well as allopurinol, respectively. Uloric is excreted much less through urine than allopurinol, making it a safer option for patients with kidney problems."

Answered by AI

Should I take Uloric during a gout attack?

"Uloric was a first-line treatment for gout in adults for almost 10 years, but in 2019 the U.S. Food and Drug Administration concluded that the drug presents a higher risk of death than a competing medicine and should not be used as the first choice for gout treatment."

Answered by AI

What are side effects of Uloric?

"Uloric reduces uric acid levels in the blood, which can lead to side effects such as nausea, rash, joint pain, gout flares, and liver problems."

Answered by AI

Clinical Trials for Uloric