← Back to Search

Cognitive Rehabilitation and Exposure Therapy for Hoarding Disorder (CREST Trial)

Waitlist Available
Led By Catherine Ayers, PhD
Research Sponsored by University of California, San Diego
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
DSM-5 diagnosis of HD
Adults age 50 and older
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 1 year
Awards & highlights

CREST Trial Summary

This trial will help us understand how to better treat hoarding disorder and reduce its negative consequences for those affected, especially older adults.

Who is the study for?
This trial is for adults aged 50 or older who have been diagnosed with Hoarding Disorder (HD) as their primary condition and are stable on medications. They must understand and agree to participate voluntarily. People with current psychosis, substance use disorders, benzodiazepine use, suicidality, neurodegenerative diseases, or those already in exposure therapy cannot join.Check my eligibility
What is being tested?
The study tests Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) combined with Case Management against HD symptoms in older adults. It aims to understand how these treatments work and reduce the severity of hoarding behaviors as well as associated disability.See study design
What are the potential side effects?
While specific side effects are not listed for this psychological intervention, participants may experience increased anxiety or emotional distress during exposure tasks designed to confront hoarding behavior.

CREST Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I have been diagnosed with Huntington's disease.
I am 50 years old or older.

CREST Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Saving Inventory-Revised (SI-R)
Change in Self-report Clutter Image Rating (CIR)
Secondary outcome measures
PROMIS-43 Profile v2.
UCSD Performance-Based Skills Assessment (UPSA-2)
Other outcome measures
Behavior Rating Inventory of Executive Function- Adult Version (BRIEF-A)
Behavioral Avoidance Task (BAT)
+2 more

CREST Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST)Experimental Treatment1 Intervention
Compensatory Cognitive Training (CCT) Modules (7 sessions). Compensatory Cognitive Training is a manualized, low-tech, cognitive training intervention designed to target cognitive impairments common in people with psychiatric illnesses. The CCT modules specifically selected for CREST map onto known areas of HD neurocognitive impairments and include training in prospective memory, prioritizing, problem solving, planning, and cognitive flexibility. Exposure to Discarding and Acquiring Modules (19 sessions). Symptoms of acquiring and saving are themselves avoidance behaviors to avoid internal distress related to negative thoughts and emotions. ET utilizes in vivo exposure exercises taking place in the home to enhance generalization of their new skills. Fear hierarchies typically start with a space that has low clutter volume or there is less of an urge to save a particular type of item in that environment.
Group II: Case Management (CM)Active Control1 Intervention
Case Management (CM). CM consists of a set of well-established strategies commonly used in community service settings to address serious and complex problems in particularly vulnerable and often marginalized populations such as those with HD.

Find a Location

Who is running the clinical trial?

University of California, San DiegoLead Sponsor
1,130 Previous Clinical Trials
1,552,706 Total Patients Enrolled
Catherine Ayers, PhDPrincipal InvestigatorUniversity of California, San Diego

Media Library

Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) Clinical Trial Eligibility Overview. Trial Name: NCT05254015 — N/A
Obsessive-Compulsive Disorder Research Study Groups: Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST), Case Management (CM)
Obsessive-Compulsive Disorder Clinical Trial 2023: Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) Highlights & Side Effects. Trial Name: NCT05254015 — N/A
Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05254015 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies available for prospective participants of this research?

"Unfortunately, this research initiative is not admitting participants at present. First published on November 21st 2022 and last updated on April 4th 2023, the trial has already concluded its recruitment period; however, there are still 1,034 other trials soliciting volunteers."

Answered by AI
~97 spots leftby Feb 2027