Diesel Exhaust and Wood Smoke for Air Pollution Exposure
(WADE Trial)
Trial Summary
Do I need to stop taking my current medications to join the trial?
The trial protocol does not specify whether you need to stop taking your current medications. However, since the study is for healthy individuals with no history of respiratory disease, it's likely that participants are not on regular medications for such conditions.
Is exposure to diesel exhaust and wood smoke generally safe for humans?
How does the Diesel Exhaust and Wood Smoke treatment differ from other treatments for air pollution exposure?
This treatment is unique because it involves controlled exposure to diesel exhaust and wood smoke, which are known to cause airway inflammation and increase the risk of lung cancer. Unlike traditional treatments that aim to reduce exposure to pollutants, this study focuses on understanding the health effects of these specific pollutants.12345
What is the purpose of this trial?
Accumulating evidence demonstrates that breathing air pollutants leads to devastating increases in sickness and death worldwide over time. However, there is little data comparing the effects of different types of air pollution on health. In Canada, traffic-related air pollution and wood smoke (wildfires and wood burning for heating) are very common air pollutants. This study aims to safely complete a controlled human exposure study to test how these air pollution types acutely affect health.
Research Team
Chris Carlsten, MD
Principal Investigator
University of British Columbia
Eligibility Criteria
This trial is for individuals with or without rhinitis (including hay fever) who are generally healthy. It aims to understand how different types of air pollution affect health.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Exposure
Participants are exposed to filtered air, wood smoke, diesel exhaust, and a combination of diesel exhaust and wood smoke, each for 2 hours with a 4-week washout period between exposures.
Follow-up
Participants are monitored for changes in biomarkers and lung function after each exposure.
Treatment Details
Interventions
- Diesel Exhaust and Wood Smoke (DEWS)
- Diesel Exhaust (DE)
- Filtered Air (FA)
- Wood Smoke (WS)
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of British Columbia
Lead Sponsor