48 Participants Needed

Diesel Exhaust and Wood Smoke for Air Pollution Exposure

(WADE Trial)

AY
PJ
Overseen ByParteek Johal
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: University of British Columbia

Trial Summary

Do I need to stop taking my current medications to join the trial?

The trial protocol does not specify whether you need to stop taking your current medications. However, since the study is for healthy individuals with no history of respiratory disease, it's likely that participants are not on regular medications for such conditions.

Is exposure to diesel exhaust and wood smoke generally safe for humans?

Exposure to diesel exhaust is linked to health risks such as lung cancer, airway inflammation, and respiratory issues like asthma and chronic bronchitis. Diesel exhaust contains harmful chemicals and is considered a probable human carcinogen, meaning it can potentially cause cancer.12345

How does the Diesel Exhaust and Wood Smoke treatment differ from other treatments for air pollution exposure?

This treatment is unique because it involves controlled exposure to diesel exhaust and wood smoke, which are known to cause airway inflammation and increase the risk of lung cancer. Unlike traditional treatments that aim to reduce exposure to pollutants, this study focuses on understanding the health effects of these specific pollutants.12345

What is the purpose of this trial?

Accumulating evidence demonstrates that breathing air pollutants leads to devastating increases in sickness and death worldwide over time. However, there is little data comparing the effects of different types of air pollution on health. In Canada, traffic-related air pollution and wood smoke (wildfires and wood burning for heating) are very common air pollutants. This study aims to safely complete a controlled human exposure study to test how these air pollution types acutely affect health.

Research Team

CC

Chris Carlsten, MD

Principal Investigator

University of British Columbia

Eligibility Criteria

This trial is for individuals with or without rhinitis (including hay fever) who are generally healthy. It aims to understand how different types of air pollution affect health.

Inclusion Criteria

I am between 19 and 40 years old.
I am healthy and have never had a lung disease.
Lifetime non-smoker and non-vaper

Exclusion Criteria

I am often exposed to smoke or diesel exhaust at home or work.
Pregnant, planning to become pregnant, or breastfeeding during the study period (confirmed through pregnancy tests at each visit if applicable)

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Exposure

Participants are exposed to filtered air, wood smoke, diesel exhaust, and a combination of diesel exhaust and wood smoke, each for 2 hours with a 4-week washout period between exposures.

16 weeks
4 visits (in-person)

Follow-up

Participants are monitored for changes in biomarkers and lung function after each exposure.

5 months

Treatment Details

Interventions

  • Diesel Exhaust and Wood Smoke (DEWS)
  • Diesel Exhaust (DE)
  • Filtered Air (FA)
  • Wood Smoke (WS)
Trial Overview The study compares the health effects of breathing in diesel exhaust and wood smoke versus filtered air. Participants will be exposed to these conditions in a controlled environment to assess acute health changes.
Participant Groups
4Treatment groups
Active Control
Placebo Group
Group I: Wood Smoke (WS)Active Control1 Intervention
Participants will be exposed to 2 hours of controlled wood smoke (WS) standardized to 300ug/m\^3 of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).
Group II: Diesel Exhaust (DE)Active Control1 Intervention
Participants will be exposed to 2 hours of controlled diesel exhaust (DE) as a model of traffic-related air pollution (TRAP) standardized to 300ug/m\^3 of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).
Group III: Diesel Exhaust and Wood Smoke (DEWS)Active Control1 Intervention
Participants will be exposed to 2 hours of combined controlled diesel exhaust (DE) and wood smoke (DEWS) standardized to 300ug/m\^3 of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).
Group IV: Filtered Air (FA)Placebo Group1 Intervention
Participants will be exposed to 2 hours of high-efficiency particulate air (HEPA) filtered air (FA).

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of British Columbia

Lead Sponsor

Trials
1,506
Recruited
2,528,000+

References

[Respiratory effects of diesel exhaust emission]. [2007]
Health effects of diesel exhaust emissions--a mixture of air pollutants of worldwide concern. [2019]
Airway inflammatory response to diesel exhaust generated at urban cycle running conditions. [2022]
Symptoms in response to controlled diesel exhaust more closely reflect exposure perception than true exposure. [2023]
Use of Dieselized Farm Equipment and Incident Lung Cancer: Findings from the Agricultural Health Study Cohort. [2021]
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