Time-Restricted Eating for Cancer Side Effect Reduction
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, if you have diabetes, you may need to hold your diabetes medication during the fasting periods, but only if your doctor agrees it's safe.
What data supports the effectiveness of the treatment Time-Restricted Eating for Cancer Side Effect Reduction?
Research suggests that short-term fasting and intermittent fasting can protect healthy cells and make cancer cells more vulnerable during chemotherapy, potentially reducing side effects. Additionally, nutritional counseling and self-management of eating problems can improve nutritional intake and quality of life for cancer patients.12345
Is time-restricted eating safe for humans, especially during cancer treatment?
How does time-restricted eating differ from other treatments for reducing cancer side effects?
Time-restricted eating is unique because it involves limiting food intake to specific hours of the day, which may help reduce cancer side effects by exploiting differences in how tumor and normal cells respond to stress. This approach can enhance the effectiveness of chemotherapy and improve surgical outcomes by strengthening normal cells and weakening tumor cells, unlike traditional treatments that do not focus on meal timing.14589
What is the purpose of this trial?
This trial studies if time-restricted eating can reduce side effects of radiation or chemoradiation in patients with prostate, cervical, and rectal cancers. It compares fasting periods to nutritional counseling to see which helps more with treatment side effects and overall health.
Research Team
Yun R. Li
Principal Investigator
City of Hope Medical Center
Eligibility Criteria
This trial is for adults with high-risk prostate, advanced rectal, or cervical cancer who are about to receive radiation or chemoradiation. They must be in good enough health to participate (ECOG 0-2) and not have had certain prior treatments like long-term hormone therapy for prostate cancer or any chemotherapy. Pregnant women, those planning pregnancy, lactating women, individuals on strict diets such as keto or paleo, and those with a BMI under 21 are excluded.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo time-restricted eating or receive nutritional counseling during radiation or chemoradiation therapy. Blood samples are collected throughout the trial.
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessments of quality of life and adverse events.
Treatment Details
Interventions
- Nutritional Counseling
- Time-Restricted Eating
Find a Clinic Near You
Who Is Running the Clinical Trial?
City of Hope Medical Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator