Medical Herbs for COVID-19

(COVID Trial)

Overseen By Wanzhu Hou, CMD, MD(CN)

Age: Any Age

Sex: Any

Trial Phase: Phase 1 & 2

Sponsor: All Natural Medicine Clinic, LLC

Disqualifiers: Prior COVID-19, Age, Severe illness, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 6 weeks

100 Participants Needed

Trial Summary

What is the purpose of this trial?

The human immune system is designed to protect individuals from external sources of infection and internal cell mutation. It works effectively and efficiently until inflammation disturbs its functioning. Once compromised by inflammation, the immune system loses its capacity to recognize antigens and dependably defend the body against disease and illness. When COVID-19 invades humans, it causes an immune-storm (cytokine-storm) that can directly damage the organ(s), leading to death. The virus is an antigen - a trigger - but it is not the actual reason that causes organ failure and death; instead, it is the body's over immune reaction that is the cause. In attempting to protect the body, the immune system overreacts to the antigen, which includes the infected cells, which causes a cytokine-storm, and the subsequent and rapid shut down of the infected individual's organ(s)' structure, leaving the body without sufficient strength or time to fight back. When the medical herbs join the body, it can slow down the immune reaction. Medical herbs benefit the physical body; they protect the cells and organism structure and mediate the immune response, allowing the T cells to kill the virus (mutated or not) internally. Such success has been achieved by the All Natural Medicine Clinic during pre-clinical trials. This clinical study's goal is to demonstrate that the immune system can be rebuilt and retrained, using natural medicine (i.e., medical herbs), to kill the virus without causing the immune storm, and to explore the mechanism by which these medical herbs, which have been used for thousands of years for healing, achieve results.

Will I have to stop taking my current medications?

The trial does not require you to stop taking your current medications. Participants who are already on conventional medication treatment can continue their treatment while participating in this study.

What data supports the effectiveness of the treatment Medical Herbs for COVID-19?

Research shows that certain herbs like Echinacea, Turmeric, and Nigella sativa have been effective in treating COVID-19 by boosting the immune system and reducing inflammation. Additionally, studies on Ayurvedic and Persian herbal treatments have shown promising results in improving symptoms and reducing hospital stay for COVID-19 patients. ^{1 2 3 4 5}

Is the herbal treatment for COVID-19 safe for humans?

Research shows that herbal medicines used for COVID-19 treatment have a safety profile similar to standard treatments, with no serious adverse reactions reported. However, the certainty of this evidence is low, and more rigorous studies are needed to confirm these findings. ^{6 7 8 9 10}

How do medical herbs differ from other treatments for COVID-19?

Medical herbs for COVID-19 are unique because they use natural plant-based ingredients that can act as immunomodulators (helping to regulate the immune system), anti-inflammatories, and antioxidants. Unlike conventional drugs, these herbs may also help restore gut health, which can be important for overall recovery from the virus. ^{2 3 11 12 13}

Research Team

Wanzhu Hou, CMD,MD(CN)

Principal Investigator

All Natural Medicine Clinic, LLC

Eligibility Criteria

This trial is for people aged 10-70 with recent (1-20 days) COVID-19 infection, regardless of gender, race, or nationality. They must have specific blood tests and lung images ready and can be on conventional treatments.

Inclusion Criteria

I am between 10 and 70 years old.

I am currently taking or have not taken standard medication for my condition.

The Participants must repeat the evaluation experiment during and at the end of the clinical study

Exclusion Criteria

Individuals with a prior COVID-19 virus infection that no longer shows up from COVID-19 testing

My child is under 10 and struggles with taking medicine on schedule.

Patients diagnosed with COVID-19 virus infection but do not willing to share their information with the public

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive medical herbs to mediate immune response and inhibit inflammation

6 weeks

Regular monitoring visits

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• Medical Herbs

Trial Overview The study tests if medical herbs can rebuild the immune system to fight COVID-19 without causing a harmful overreaction. It compares standard care with three different herbal inflammation treatments.

Participant Groups

Group I: Inflammation (III) Active Control 2 Interventions

1. Metabolites 2. Clots

Group II: Inflammation (I) Active Control 2 Interventions

1. Upper respiratory inflammation. 2. Fever. 3. Lower respiration inflammation.

Group III: Inflammation (II) Active Control 2 Interventions

Cough, chest pain

Who Is Running the Clinical Trial?

All Natural Medicine Clinic, LLC

Lead Sponsor

Trials

2

Recruited

2,100+

Findings from Research

In a study of 167 COVID-19 positive patients treated with Ayurvedic interventions, there was a quick resolution of symptoms and no deterioration in any cases, indicating effective management of the disease.

The Ayurvedic treatment was safe, with no adverse events reported, and it was particularly beneficial for patients with multiple comorbidities, suggesting its potential as a low-cost option for early intervention in COVID-19.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Stand-alone Ayurvedic intervention with home quarantine in COVID-19 - Outcomes of clinical practice. Girija, PLT., Sivan, N., Murugavel, YA., et al.[2022]

Phytopharmaceuticals significantly improved recovery rates in COVID-19 patients (odds ratio of 3.54) and reduced mortality (odds ratio of 0.24), indicating their potential effectiveness as a treatment option.

These herbal medicines also provided protective effects against specific COVID-19 symptoms like dyspnea and myalgia, although they did not show significant effects on cough and fever, suggesting targeted benefits in symptom management.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The Efficacy of Herbs as Complementary and Alternative Therapy in Recovery and Clinical Outcome Among People with COVID-19: A Systematic Review, Meta-Analysis, and Meta-Regression. Komariah, M., Amirah, S., Maulana, S., et al.[2023]

Only 18% of university students reported using Chinese herbs to prevent COVID-19, indicating a gap between positive attitudes and actual practices.

Despite a generally positive attitude towards Chinese herbal medicine, students demonstrated a lack of knowledge, scoring an average of only 1.64 out of 5 on related knowledge assessments, highlighting the need for better education on the pharmacological properties of these herbs.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Practices, Knowledge, and Attitudes of Chinese University Students Toward Traditional Chinese Herbal Medicine for the Control of COVID-19. Li, H., Liu, J., Hu, X., et al.[2022]

In a study involving 358 hospitalized patients, those who received herbal remedies alongside standard care experienced a significantly shorter duration of hospital stay due to respiratory symptoms (3.29 days vs. 6.47 days).

The herbal treatment also led to faster clinical improvement and reduced various symptoms associated with respiratory infections, suggesting that these polyherbal formulations could be a promising adjunct therapy for managing COVID-19 with good tolerability.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Efficacy of Persian medicine herbal formulations (capsules and decoction) compared to standard care in patients with COVID-19, a multicenter open-labeled, randomized, controlled clinical trial. Karimi, M., Zarei, A., Soleymani, S., et al.[2021]

In a randomized clinical trial involving 150 hospitalized COVID-19 patients, olive leaf extract significantly improved vital signs and laboratory markers compared to a placebo, indicating its potential efficacy in managing COVID-19 symptoms.

Both doses of olive leaf extract (250 mg and 500 mg every 12 hours for five days) resulted in lower body temperature, pulse rate, respiratory rate, and inflammatory markers, while improving oxygen saturation, suggesting it may enhance recovery and reduce hospitalization duration.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Efficacy of olive leaves extract on the outcomes of hospitalized covid-19 patients: A randomized, triple-blinded clinical trial. Ahmadpour, E., Toulabi, T., Yadegarinia, D., et al.[2023]

A review of seven randomized controlled trials involving 855 patients found that combining herbal medicine with Western medicine significantly improved treatment outcomes for COVID-19, including higher rates of symptom disappearance for cough and sputum production.

No serious adverse events were reported, suggesting that the combined therapy is safe; however, the overall risk of bias in the studies was unclear, indicating a need for more high-quality research to confirm these findings.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Herbal Medicine for the Treatment of Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Ang, L., Song, E., Lee, HW., et al.[2023]

A systematic review of 35 randomized controlled trials and 24 observational studies involving 16,580 mild to moderate COVID-19 patients found that Chinese herbal medicine (CHM) significantly reduced the rate of conversion to severe cases and mortality compared to usual supportive treatments.

CHM also helped shorten the time to symptom resolution, length of hospital stay, and time to viral clearance, while showing a safety profile comparable to standard care, with no serious adverse reactions reported.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Efficacy and safety of chinese herbal medicine for treating mild or moderate COVID-19: A systematic review and meta-analysis of randomized controlled trials and observational studies. Zhu, H., Li, M., Tian, C., et al.[2022]

A systematic review of 32 randomized controlled trials involving 3177 COVID-19 patients found that herbal interventions, when used alongside Western medicine, significantly improved symptoms like fever, cough, and fatigue compared to Western medicine alone.

The study indicated that herbal treatments also led to better laboratory outcomes, such as improved white blood cell counts and lymphocyte percentages, without significant adverse events reported, suggesting a safe complementary approach to COVID-19 management.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Role of herbal medicines in the management of patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials. Kumar, A., Rai, A., Khan, MS., et al.[2022]

Herbal medicine, when used alongside standard COVID-19 treatments, showed significant benefits in improving symptoms such as fever, cough, and fatigue, as well as reducing hospital stay duration and all-cause mortality, based on a meta-analysis of randomized controlled trials.

Despite these positive findings, the overall certainty of the evidence is low due to methodological limitations in the studies, and there were no significant differences in adverse events between herbal medicine and standard treatment alone.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Herbal Medicine Intervention for the Treatment of COVID-19: A Living Systematic Review and Cumulative Meta-Analysis. Ang, L., Song, E., Hu, XY., et al.[2023]

A Persian herbal medicine formula significantly reduced the mean hospitalization days for COVID-19 patients by approximately 2.95 days compared to those receiving only routine treatment, based on a study of 79 hospitalized patients.

The herbal treatment also led to notable improvements in symptoms such as dyspnea and the need for oxygen therapy, with no reported adverse effects, suggesting it could be a safe adjuvant therapy for COVID-19.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Efficacy of a Persian herbal medicine compound on coronavirus disease 2019 (COVID-19): A randomized clinical trial. Setayesh, M., Karimi, M., Zargaran, A., et al.[2022]

COVID-19 can cause gastrointestinal symptoms, indicating that the gastrointestinal tract may be a target for SARS-CoV-2, as the virus uses the ACE2 receptor, which is highly expressed in intestinal cells.

Herbal treatments may help restore the balance of intestinal flora, potentially improving immune function and aiding recovery from COVID-19, suggesting a new approach to managing the disease.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Herbal Medicine, Gut Microbiota, and COVID-19. Chen, Z., Lv, Y., Xu, H., et al.[2022]

The use of traditional Chinese medicine (TCM) during the COVID-19 pandemic is positively correlated with higher regional cure rates in China, suggesting its potential effectiveness in treatment.

Analysis of 185 TCM recipes revealed that several commonly used herbs have direct anti-SARS-CoV-2 properties, with the top candidate, madreselvin B, showing promising binding affinity to key viral proteins, indicating a multifactorial mechanism of action that includes immunoregulation and anti-inflammatory effects.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Herbal plants coordinate COVID-19 in multiple dimensions - An insight analysis for clinically applied remedies. Zhang, Y., Li, Y., Wang, X., et al.[2022]

Traditional Chinese medicine (TCM) was used in 91.50% of COVID-19 cases in China, showing promising results in managing symptoms and reducing severe outcomes like mortality and recurrence rates.

A total of 166 modified herbal formulae were identified, with key herbs like Glycyrrhizae Radix et Rhizome and Scutellariae Radix being frequently used, and 12 clusters of molecules were analyzed for their potential to inhibit the coronavirus, suggesting a systematic approach to developing effective treatments.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Analysis on herbal medicines utilized for treatment of COVID-19. Luo, L., Jiang, J., Wang, C., et al.[2020]

References

1. United States pubmed.ncbi.nlm.nih.gov

Stand-alone Ayurvedic intervention with home quarantine in COVID-19 - Outcomes of clinical practice. [2022]

2. New Zealand pubmed.ncbi.nlm.nih.gov

The Efficacy of Herbs as Complementary and Alternative Therapy in Recovery and Clinical Outcome Among People with COVID-19: A Systematic Review, Meta-Analysis, and Meta-Regression. [2023]

3. New Zealand pubmed.ncbi.nlm.nih.gov

Practices, Knowledge, and Attitudes of Chinese University Students Toward Traditional Chinese Herbal Medicine for the Control of COVID-19. [2022]

4. England pubmed.ncbi.nlm.nih.gov

Efficacy of Persian medicine herbal formulations (capsules and decoction) compared to standard care in patients with COVID-19, a multicenter open-labeled, randomized, controlled clinical trial. [2021]

5. United States pubmed.ncbi.nlm.nih.gov

Efficacy of olive leaves extract on the outcomes of hospitalized covid-19 patients: A randomized, triple-blinded clinical trial. [2023]

6. Switzerland pubmed.ncbi.nlm.nih.gov

Herbal Medicine for the Treatment of Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [2023]

7. Switzerland pubmed.ncbi.nlm.nih.gov

Efficacy and safety of chinese herbal medicine for treating mild or moderate COVID-19: A systematic review and meta-analysis of randomized controlled trials and observational studies. [2022]

8. Netherlands pubmed.ncbi.nlm.nih.gov

Role of herbal medicines in the management of patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials. [2022]

9. Switzerland pubmed.ncbi.nlm.nih.gov

Herbal Medicine Intervention for the Treatment of COVID-19: A Living Systematic Review and Cumulative Meta-Analysis. [2023]

10. Netherlands pubmed.ncbi.nlm.nih.gov

Efficacy of a Persian herbal medicine compound on coronavirus disease 2019 (COVID-19): A randomized clinical trial. [2022]

11. Switzerland pubmed.ncbi.nlm.nih.gov

Herbal Medicine, Gut Microbiota, and COVID-19. [2022]

12. Australia pubmed.ncbi.nlm.nih.gov

Herbal plants coordinate COVID-19 in multiple dimensions - An insight analysis for clinically applied remedies. [2022]

13. Netherlands pubmed.ncbi.nlm.nih.gov

Analysis on herbal medicines utilized for treatment of COVID-19. [2020]