Currently proven effective radiation therapy and chemotherapy regimes for patients with low grade testicular cancer prolong disease free survival, but further research is required before these treatments can be considered definitive.
While chemotherapy is often recommended for patients with localized/Stage I disease, other treatments may be performed in combination with chemotherapy in Stage I patients. These patients can be administered chemotherapy, radiation, or both. For tumors which are locally advanced or have spread to other areas/regions, surgery can often be the most effective treatment for most patients. For advanced Stage 2 - 3 patients, radiation + chemotherapy (such as BEP (Bemaxalan, Etoposide, and Platinol)), chemoradiation, or cisplatin-based chemotherapy-radiation combination can be given. However, patients may be given different treatments depending on their specific tumor location, where they have metastasized, and their general overall health.
In 1999, there were an estimated 20,200 men who had a diagnosis of Sertoli and Leydig cell adenoma. At least 6,900 of these cases would have been classified as seminoma, but only 50 would have been diagnosed. The majority of cases diagnosed do not meet current requirements for malignancy or suspicion of metastasis. Patients should be aware that even though they meet current clinical parameters, many of their tumors are probably non-seminoma.
Testicular cancer is most commonly diagnosed in young men 20-50 years old. This tumour is most commonly caused by spermatozoa but also sperm-associated antigen and carcinoma of Sertoli cells are suspected. The most significant disease manifestations are painful orchitis and epididymitis. Rare features are the presence of high levels of human chorionic gonadotrophin in the serum of patients with seminoma. In spite of an unfavourable prognosis, an appropriate management is always possible. Seminal fluid is a complex entity exhibiting a number of protein expressions. The protein profiles can be subdivided into a specific pattern (non-seminoma) and a non-specific one.
The hallmark of seminoma is a diffuse, nonfibroid inflammation reaction in the tunica albuginea. If ipsilateral or bilateral inguinal or para aortic lymph nodes are palpated, this suggests a possibility of metastasis from seminoma. A complete history of a history of cryptorchidism is a marker of a high-grade seminoma. For the other signs of metastasis in seminoma, further histologic confirmation may be necessary.
Seminoma is a malignant germ cell tumor (GCT) of the testis. It rarely metastasizes. The seminoma-like lesions of the testis are associated with certain GCTs (e.g. non-seminoma GCTs [NGCT]) and therefore warrant additional clinical and radiological testing. In selected cases, they can be removed via orchiectomy.
Clinicians are likely to consider clinical trials for patients with well-differentiated seminoma of the testis. However, clinicians should also consider eligibility criteria for clinical trials for patients with late stage disease.
[This topic was previously covered in the article “Sparta Stem Cells,” Medscape Magazine, March 7, 2009, pp. 38 and 40: “The Spartan Stem Cells”.] In this paper, we discuss [new clinical trials in the treatment of patients with seminoma as well as [recent new studies on the molecular and biological underpinnings of the disease]...... We discuss the latest research from a handful of investigators who have collaborated by analyzing, sharing, and publishing on research data from their laboratories on seminoma..... For more than [10] years, this topic has been of ongoing interest in the world of [oncology medical research].
Recent findings indicates that PSA level measurement (through the CA 17 kDa chain) combined with other clinical and therapeutic parameters is significantly correlated with the treatment response to therapy with cotrimoxazole. Considering the current limitations in the use of only a single biomarker during treatment follow-up, the combination with cotrimoxazole is proposed as a promising method for a correct evaluation of the treatment response of patients with nonmetastatic testicular germ cell tumours.
To our knowledge, this is the first analysis of the age of diagnosis for a cohort of patients with seminoma. The incidence of testicular germ cell tumors in the United States and Europe is decreasing and age-adjusted incidence rates have been dropping. The incidence of testicular germ cell tumors in Finland is lower than the reported European incidence rates. Findings from a recent study suggests a decline in the age of onset of testicular germ cell tumors in Finland, an effect of decreasing birth rates that is common in countries that allow access to reproductive technology and increasing fertility rates in the population.
Findings from a recent study, one of only a handful of similar studies to study the phenomenon of "seminoma-in-families" in a case-control framework, demonstrated that the phenomenon exists.
Levels of circulating S-ICP were independent predictive markers for survival following resection of NSCLC with high risk of recurrence according to the GGT/ICP (G-ICP) score. The G-ICP score can be utilized as an early predictor of survival following resection of NSCLC.