Exercise for Memory Improvement in Epilepsy
(EMemRE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests if an exercise program can improve memory in adults with epilepsy by making their brain work better, especially the part that helps with remembering things.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the study team or your doctor.
Is exercise, including combined endurance and resistance training, generally safe for humans?
Exercise, including combined endurance and resistance training, is generally safe for humans when properly supervised and tailored to individual health conditions. Studies show that such exercise can be safely included in rehabilitation programs for various conditions, like cardiac rehabilitation, with appropriate precautions and supervision.12345
How does the Delayed supervised combined endurance and resistance training (CERT) treatment for memory improvement in epilepsy differ from other treatments?
This treatment is unique because it combines endurance and resistance exercises to improve memory and brain function in people with epilepsy, which is not a standard approach for this condition. It focuses on enhancing physical fitness and brain connectivity, potentially leading to better memory performance.678910
What data supports the effectiveness of the treatment Delayed supervised combined endurance and resistance training (CERT) for memory improvement in epilepsy?
Research shows that combining endurance and resistance training can improve physical function and cognitive abilities in various conditions, such as hypertension and type 2 diabetes. This suggests that similar exercise programs might also benefit memory and cognitive function in people with epilepsy.23111213
Who Is on the Research Team?
Jane B. Allendorfer, Ph.D.
Principal Investigator
University of Alabama at Birmingham
Are You a Good Fit for This Trial?
This trial is for English-speaking adults aged 18-55 with Idiopathic generalized epilepsy (IGE) who are relatively healthy, not very active physically, and have had no more than 4 seizure days per month in the past half year. They must be able to undergo MRI scans and cannot be pregnant or involved in another intervention study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants engage in a 6-week supervised and structured exercise program combining endurance and resistance training for memory rehabilitation
Follow-up
Participants are monitored for memory benefits and brain changes 6 weeks after completing the exercise intervention
What Are the Treatments Tested in This Trial?
Interventions
- Delayed supervised combined endurance and resistance training (CERT)
- Supervised combined endurance and resistance training (CERT)
Delayed supervised combined endurance and resistance training (CERT) is already approved in United States for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Alabama at Birmingham
Lead Sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborator