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Exercise for Memory Improvement in Epilepsy

N/A
Recruiting
Led By Jane B. Allendorfer, Ph.D.
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Clinician-confirmed diagnosis of IGE (including epilepsy syndromes such as juvenile myoclonic epilepsy, juvenile absence epilepsy, childhood absence epilepsy, and generalized tonic-clonic seizures alone)
Males and females aged 18-55 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6-weeks after baseline
Awards & highlights

Study Summary

This trial will study how well an exercise program improves memory in people with IGE, as well as any changes in the brain that may be responsible for these improvements.

Who is the study for?
This trial is for English-speaking adults aged 18-55 with Idiopathic generalized epilepsy (IGE) who are relatively healthy, not very active physically, and have had no more than 4 seizure days per month in the past half year. They must be able to undergo MRI scans and cannot be pregnant or involved in another intervention study.Check my eligibility
What is being tested?
The study tests a 6-week supervised exercise program's effectiveness on memory improvement in IGE patients compared to those with no intervention. It also examines brain changes due to the exercise and if improvements persist after six weeks post-intervention.See study design
What are the potential side effects?
While specific side effects aren't listed for this type of physical training, participants may experience typical exercise-related discomforts such as muscle soreness, fatigue, or strain injuries.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been diagnosed with a type of generalized epilepsy.
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I am between 18 and 55 years old.
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I've had 4 or fewer days with seizures each month for the last 6 months.
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My recent brain MRI, if available, shows no abnormalities.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6-weeks after baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6-weeks after baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
estimated interaction effect between exercise group and visit for d'
estimated mediation effect of change in left hippocampus resting state functional connectivity (rsFC) in the effect of exercise on change in d'
Secondary outcome measures
estimated interaction effect between exercise group and visit for Learning score
estimated interaction effect between exercise group and visit for Long Delay Free Recall score
estimated interaction effect between exercise group and visit for Montreal Cognitive Assessment (MoCA) score
+3 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Immediate ExerciseExperimental Treatment1 Intervention
immediate participation in 6-week exercise program (intervention)
Group II: Delayed ExerciseExperimental Treatment1 Intervention
6-week delay (no-intervention control) prior to participating in exercise program

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor
1,573 Previous Clinical Trials
2,273,163 Total Patients Enrolled
Jane B. Allendorfer, Ph.D.Principal InvestigatorUniversity of Alabama at Birmingham

Media Library

Delayed supervised combined endurance and resistance training (CERT) Clinical Trial Eligibility Overview. Trial Name: NCT04959019 — N/A
Memory Loss Research Study Groups: Immediate Exercise, Delayed Exercise
Memory Loss Clinical Trial 2023: Delayed supervised combined endurance and resistance training (CERT) Highlights & Side Effects. Trial Name: NCT04959019 — N/A
Delayed supervised combined endurance and resistance training (CERT) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04959019 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To what extent is the patient population being augmented for this medical experiment?

"Affirmative. Clinicaltrials.gov displays that this clinical trial is presently recruiting participants, having first been posted on July 21st 2021 and last updated on February 21st 2022. 114 volunteers must be sourced from 1 location for the study to proceed as planned."

Answered by AI

Does this medical experiment have any age restrictions, particularly for those beyond the half-century mark?

"Stipulated by the eligibility regulations, participants of this clinical trial must be aged 18-55."

Answered by AI

Are there any current opportunities for individuals to enroll in this clinical trial?

"Affirmative. Clinicaltrials.gov has the most up-to-date information and indicates that this clinical trial is on the hunt for 114 research participants from a single location. This investigation was initially posted in July 2021, with its latest update taking place in February 2022."

Answered by AI

Who else is applying?

What state do they live in?
Alabama
How old are they?
18 - 65
What portion of applicants met pre-screening criteria?
Met criteria
What site did they apply to?
University of Alabama at Birmingham
~45 spots leftby Dec 2025