Transcranial Magnetic Stimulation During Cognitive Tasks for Healthy Subjects
Trial Summary
Do I have to stop taking my current medications for this trial?
The trial does not specify if you must stop taking your current medications, but you cannot participate if you are currently using or have recently stopped using medications that can increase the risk of seizure.
Will I have to stop taking my current medications?
The trial excludes people who are currently using medications that can increase the risk of seizure, so you may need to stop taking such medications to participate.
What data supports the idea that Transcranial Magnetic Stimulation During Cognitive Tasks for Healthy Subjects is an effective treatment?
The available research shows that Transcranial Magnetic Stimulation (rTMS) can improve cognitive processing and attention in healthy subjects. One study found that rTMS significantly decreased reaction time and improved cognitive processing when applied to the left prefrontal cortex. Another study showed that rTMS improved attentional function by reducing reaction time and errors in performance tests. These findings suggest that rTMS can enhance certain cognitive functions in healthy individuals.12345
What data supports the effectiveness of the treatment Transcranial Magnetic Stimulation, rTMS, Repetitive Transcranial Magnetic Stimulation?
Research shows that repetitive transcranial magnetic stimulation (rTMS) can improve cognitive processing and attentional function in healthy subjects. Studies found that high-frequency rTMS applied to specific brain areas, like the left prefrontal cortex, can lead to faster reaction times and fewer errors in cognitive tasks.12345
What safety data exists for transcranial magnetic stimulation?
Safety data for transcranial magnetic stimulation (TMS) and its repetitive form (rTMS) indicate that while it is generally safe, there are potential risks and side effects. Known risks include the possibility of inducing seizures, with 7 cases reported by 1996. Mild adverse effects such as headaches and nausea have been observed, and discomfort during stimulation can affect task performance. Guidelines have been developed to ensure safe use, including limits on stimulation parameters and monitoring of subjects. Studies have shown that when applied within these guidelines, TMS is relatively safe for healthy subjects, with no significant changes in neurological, cognitive, or motor functions observed in some trials.678910
Is transcranial magnetic stimulation (TMS) safe for healthy humans?
Transcranial magnetic stimulation (TMS) is generally considered safe for healthy people, but it can cause mild side effects like headaches and nausea. There is a small risk of seizures, especially with repetitive TMS (rTMS), but following safety guidelines can minimize this risk. Some studies have shown no adverse effects on neurological or cognitive functions when TMS is used within recommended limits.678910
Is transcranial magnetic stimulation a promising treatment for improving cognitive tasks in healthy people?
Yes, transcranial magnetic stimulation (TMS) is a promising treatment for improving cognitive tasks in healthy people. Studies show that TMS can enhance cognitive processing, improve attention, and reduce reaction times. It works by stimulating specific areas of the brain, which can lead to better performance in tasks that require thinking and memory.123411
How is transcranial magnetic stimulation during cognitive tasks different from other treatments?
Transcranial magnetic stimulation (TMS) is unique because it uses magnetic fields to stimulate specific areas of the brain, which can enhance cognitive processing and attention in healthy individuals. Unlike other treatments that might involve medication or invasive procedures, TMS is non-invasive and can target brain regions directly involved in cognitive tasks.123411
What is the purpose of this trial?
The study will examine whether the benefits of brain stimulation on mental functioning can be enhanced if an individual is actively engaging the target brain networks while receiving brain stimulation. The study includes two separate sessions and people will complete either a cognitive task or a perceptual task while receiving transcranial magnetic stimulation. The study will measure change in brain function with EEG.
Research Team
Alik Widge, MD, PhD
Principal Investigator
University of Minnesota
Eligibility Criteria
This trial is for healthy individuals aged between 18 and 65. Participants should not be pregnant, have metal in their head (except dental fillings), diagnosed psychiatric disorders, epilepsy or history of seizures, recent concussions, adverse reactions to TMS/MRI, neurological conditions like stroke or tinnitus, or implanted medical devices.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive transcranial magnetic stimulation while engaging in cognitive or perceptual tasks
Follow-up
Participants are monitored for changes in brain function using EEG after TMS
Treatment Details
Interventions
- Transcranial Magnetic Stimulation
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Minnesota
Lead Sponsor