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Behavioural Intervention
Transcranial Magnetic Stimulation for Memory Improvement
N/A
Recruiting
Led By David E Warren, PhD
Research Sponsored by University of Nebraska
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Healthy adults without history of psychiatric or neurological disease OR previous diagnosis of amnestic MCI
Adults 19 years of age and older
Timeline
Screening 3 weeks
Treatment Varies
Follow Up potential changes will be assessed after each one-week rtms treatment period. results will be reported at the end of the study (approximately one year).
Awards & highlights
Study Summary
This trial is testing whether transcranial magnetic stimulation (TMS) can improve memory in healthy adults (young and old) and treat memory deficits in older adults with amnestic mild cognitive impairment (aMCI), which often precedes Alzheimer's disease.
Who is the study for?
This trial is for adults over 19, either healthy or with mild memory issues (aMCI), who can follow instructions and sit still for tests. They must be right-handed and speak English natively. It's not for those with metal implants (except dental), major illnesses, substance abuse problems, seizures, other neurological disorders, or pregnant women.Check my eligibility
What is being tested?
The study is testing if targeted brain stimulation using rTMS can improve memory in healthy young and older adults as well as those with aMCI by affecting brain network connectivity related to memory.See study design
What are the potential side effects?
rTMS is generally considered safe but may cause discomfort at the stimulation site, headache, lightheadedness, or rare seizures.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am a healthy adult with no psychiatric or neurological diseases, or I have been diagnosed with amnestic MCI.
Select...
I am 19 years old or older.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ potential changes will be assessed after each one-week rtms treatment period. results will be reported at the end of the study (approximately one year).
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~potential changes will be assessed after each one-week rtms treatment period. results will be reported at the end of the study (approximately one year).
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Changes in memory performance measured with the number of studied face-word associations recalled
Secondary outcome measures
Changes in intrinsic functional connectivity between the target brain region stimulated with rTMS and other brain regions.
Trial Design
2Treatment groups
Experimental Treatment
Group I: Arm B: Sham then StimulationExperimental Treatment1 Intervention
All procedures are identical in both arms with the exception of the order of stimulation administration. In Arm B, sham stimulation will be applied in the first week of participation, and transcranial magnetic stimulation (TMS) will be applied in the second week of participation.
Group II: Arm A: Stimulation then ShamExperimental Treatment1 Intervention
All procedures are identical in both arms with the exception of the order of stimulation administration. In Arm A, transcranial magnetic stimulation (TMS) will be applied in the first week of participation, and sham stimulation will be applied in the second week of participation.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Transcranial magnetic stimulation
2015
Completed Phase 4
~480
Find a Location
Who is running the clinical trial?
University of NebraskaLead Sponsor
539 Previous Clinical Trials
1,144,664 Total Patients Enrolled
National Institute of General Medical Sciences (NIGMS)NIH
269 Previous Clinical Trials
248,740 Total Patients Enrolled
David E Warren, PhDPrincipal InvestigatorUniversity of Nebraska
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You currently have a diagnosis of alcohol or drug addiction.You have metal implants in your body that cannot be taken out, except for in your teeth.I have high pressure inside my skull.I am a healthy adult with no psychiatric or neurological diseases, or I have been diagnosed with amnestic MCI.You are not right-handed based on what you say or a test.I have aMCI but no other neurological disorders like stroke or brain injury.I have a major medical condition like cancer, HIV, hepatitis, or heart disease.Women who are pregnant, as confirmed by a urine test, cannot participate in the study because it is not known how the study procedures might affect the unborn baby.You have more than one diagnosis that could make it hard to understand the effects of the study treatment.I am 19 years old or older.I have epilepsy, a history of seizures, or take medication that could lower my seizure threshold.
Research Study Groups:
This trial has the following groups:- Group 1: Arm A: Stimulation then Sham
- Group 2: Arm B: Sham then Stimulation
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
To what extent is participant enrollment for this trial being pursued?
"Affirmative. Details on clinicaltrials.gov illustrate that this medical trial, which was initially posted on January 1st 2019 is presently recruiting patients - 70 individuals from a single site are required to complete the study."
Answered by AI
Are there still available openings for this experiment?
"Affirmative. Clinicaltrials.gov shows that this clinical trial is still open for recruitment, which began on the first of January 2019 and was most recently updated on 24th January 2022. 70 patients are needed from one medical centre to participate in this research."
Answered by AI
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