Computerized Cognitive Tests for Neurological Disease

Overseen By Alexander Cervinsky, PhD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: NYU Langone Health

Disqualifiers: Severe dementia, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

137 Participants Needed

Trial Summary

What is the purpose of this trial?

This trial is testing three new computer-based tasks to measure brain and thinking skills. It involves both healthy people and those with neurological problems. The study aims to see if these new tasks are as good as traditional paper tests by comparing results from both methods.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment Computer-based Neuropsychological Tool for neurological diseases?

The research indicates that computerized neuropsychological tests can be more sensitive than traditional methods like the mini-mental state examination in identifying cognitive issues, especially in elderly subjects with memory complaints. This suggests that computer-based tools may effectively enhance the assessment and monitoring of cognitive changes. ^{1 2 3 4 5}

Is it safe to participate in a clinical trial using computerized cognitive tests for neurological disease?

Computerized cognitive tests, also known as computerized neuropsychological assessments, have been used safely in various settings, including occupational medicine and public health, to screen for cognitive impairments. These tests are generally considered safe, as they involve non-invasive methods like computer-based tasks to evaluate cognitive functions. ^{5 6 7 8 9}

How is the Computer-based Neuropsychological Tool treatment different from other treatments for neurological diseases?

The Computer-based Neuropsychological Tool is unique because it uses computerized tests to assess and manage cognitive impairments, offering a fast, efficient, and cost-effective alternative to traditional paper-and-pencil tests. It allows for remote administration and can be integrated with standard computer systems, making it accessible and convenient for both patients and healthcare providers. ^{5 10 11 12 13}

Research Team

Alexander Chervinsky, PhD

Principal Investigator

NYU Langone Health

Eligibility Criteria

This trial is for men and women aged 21-65, both healthy individuals and those with significant brain findings on neuroimaging. Participants must have good perception and motor skills to do the tests but can't join if they have severe dementia or lack the necessary perceptual/motor abilities.

Inclusion Criteria

Individuals without positive cerebral findings on neuroimaging (Non-PCF)

I am between 21 and 65 years old.

I am between 21 and 65 years old.

Exclusion Criteria

I am physically and mentally able to participate in tests.

I do not have severe dementia that affects my understanding.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Testing

Participants complete both computerized and paper-and-pencil neuropsychological tests to assess reliability and validity

4-6 weeks

1 visit (in-person)

Follow-up

Participants are monitored for any changes in cognitive performance post-testing

4 weeks

Treatment Details

Interventions

• Computer-based Neuropsychological Tool

Trial Overview The study is testing three new computer-based cognitive function tests against traditional paper-and-pencil methods. It aims to see if these digital tasks are more effective by comparing results from healthy controls and patients with neurological impairments.

Participant Groups

Group I: Non-CNI participants Active Control 10 Interventions

Identified from the department of Rehabilitation, Psychiatry, and Medicine and referred to the research staff via in-person communication, email or staff message

Group II: Cerebral neurological illness (CNI) participants Active Control 10 Interventions

Identified from the department of Rehabilitation, Psychiatry, and Medicine and referred to the research staff via in-person communication, email or staff message

Who Is Running the Clinical Trial?

NYU Langone Health

Lead Sponsor

Trials

1,431

Recruited

838,000+

References

1. Ireland pubmed.ncbi.nlm.nih.gov

Human-computer interaction in the administration and analysis of neuropsychological tests. [2019]

2. England pubmed.ncbi.nlm.nih.gov

Practice parameters facilitating adoption of advanced technologies for enhancing neuropsychological assessment paradigms. [2019]

3. United States pubmed.ncbi.nlm.nih.gov

Computerized assessment in neuropsychology: a review of tests and test batteries. [2022]

4. United Arab Emirates pubmed.ncbi.nlm.nih.gov

Computerized methods in the assessment and prediction of dementia. [2022]

5. Netherlands pubmed.ncbi.nlm.nih.gov

Psique: Computerised Neuropsychological Assessment. [2020]

6. United States pubmed.ncbi.nlm.nih.gov

Development of a computer-based battery designed to screen adults for neuropsychological impairment. [2019]

7. Chile pubmed.ncbi.nlm.nih.gov

[Workers exposed to styrene: application of a neuropsychological evaluation computer system]. [2006]

8. England pubmed.ncbi.nlm.nih.gov

Computerized neuropsychological assessment devices: joint position paper of the American Academy of Clinical Neuropsychology and the National Academy of Neuropsychology. [2022]

9. United States pubmed.ncbi.nlm.nih.gov

Computerized neuropsychological assessment devices: joint position paper of the American Academy of Clinical Neuropsychology and the National Academy of Neuropsychology. [2022]

10. United States pubmed.ncbi.nlm.nih.gov

A computerized test battery sensitive to mild and severe brain injury. [2021]

11. United States pubmed.ncbi.nlm.nih.gov

Applications of computer-based neuropsychological assessment. [2022]

12. United States pubmed.ncbi.nlm.nih.gov

Sources of error in computerized neuropsychological assessment. [2007]

13. England pubmed.ncbi.nlm.nih.gov

Why are neuropsychologists so reluctant to embrace modern assessment techniques? [2020]