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Stress Response Testing for Alzheimer's Risk (Stress-AD Trial)

N/A

Recruiting

Led By Cynthia A Munro, PhD

Research Sponsored by Johns Hopkins University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline to visit 3 (up to 2 years)

Awards & highlights

Stress-AD Trial Summary

This trial will investigate how genetics and the response to stress affect cognitive decline in people with mild cognitive impairment. Participants will provide samples and take tests over 2 years.

Who is the study for?

This trial is for English-speaking individuals aged 60 or older with mild cognitive impairment (MCI), who can consent to the study and have a 'study partner' available. They must be able to return for follow-up after two years, have a BMI between 17 and 30, and meet specific clinical criteria for MCI.Check my eligibility

What is being tested?

The study uses the Trier Social Stress Test to understand if stress hormones predict cognitive decline in those at risk for Alzheimer's. It explores how genes linked to Alzheimer's affect this relationship and whether they forecast changes in cognition and biomarkers over two years.See study design

What are the potential side effects?

While not explicitly listed, potential side effects may include stress from the social test procedure, discomfort from blood draws, possible anxiety during memory tests, or emotional responses when discussing daily functioning.

Stress-AD Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline to visit 3 (up to 2 years)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline to visit 3 (up to 2 years)

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to visit 3 (up to 2 years) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in mean executive test composite score

Change in mean memory test composite score

Secondary outcome measures

Change (in nanogram per liter; ng/L) in level of neurofilament light (NF-L)

Stress-AD Trial Design

1Treatment groups

Experimental Treatment

Group I: Trier Social Stress TestExperimental Treatment1 Intervention

All participants in the study will get undergo the same stress procedure

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Trier Social Stress Test

2017

N/A

~300

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

National Institute on Aging (NIA)NIH

1,675 Previous Clinical Trials

28,020,645 Total Patients Enrolled

Johns Hopkins UniversityLead Sponsor

2,266 Previous Clinical Trials

14,837,257 Total Patients Enrolled

Cynthia A Munro, PhDPrincipal InvestigatorJohns Hopkins School of Medicine

1 Previous Clinical Trials

52 Total Patients Enrolled

Media Library

Trier Social Stress Test Clinical Trial Eligibility Overview. Trial Name: NCT05795634 — N/A

Trier Social Stress Test 2023 Treatment Timeline for Medical Study. Trial Name: NCT05795634 — N/A

Mild Cognitive Impairment Research Study Groups: Trier Social Stress Test

Mild Cognitive Impairment Clinical Trial 2023: Trier Social Stress Test Highlights & Side Effects. Trial Name: NCT05795634 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment in this research endeavor still open?

"The clinical trial registry on clinicaltrials.gov states that this experimental study is now enlisting participants. It was first submitted to the platform on March 1st 2023 and has seen its last update occurring later in the month, on March 20th 2023."

Answered by AI

What is the aggregate figure of individuals participating in this clinical investigation?

"Affirmative. Per the information on clinicaltrials.gov, this research study is presently enlisting participants. It was initially announced on March 1st 2023 and recently updated on March 20th 2023; it seeks 240 individuals for a single centre trial."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease

2023. "Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05795634.

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