Study Summary
This trial is testing whether a lower dose of a chemotherapy drug, given more often, is as effective as a higher dose of the drug given less often, in treating patients with head and neck cancer.
- Laryngeal Squamous Cell Carcinoma
- Squamous Cell Carcinoma of the Head and Neck
- Oropharyngeal Cancer
- Squamous Cell Carcinoma of Unknown Primary
- Advanced Hypopharyngeal Squamous Cell Carcinoma
- Head and Neck Cancer
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
3 Primary · 5 Secondary · Reporting Duration: Up to 9 years
Trial Safety
Phase-Based Safety
Awards & Highlights
Trial Design
4 Treatment Groups
Arm IV (low-dose cisplatin, radiation therapy)
1 of 4
Arm III (high-dose cisplatin, radiation therapy)
1 of 4
ARM I (high-dose cisplatin, radiation therapy)
1 of 4
Arm II (low-dose cisplatin, radiation therapy)
1 of 4
Experimental Treatment
464 Total Participants · 4 Treatment Groups
Primary Treatment: Quality-of-Life Assessment · No Placebo Group · Phase 2 & 3
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 2 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Who else is applying?
What state do they live in?
Louisiana | 100.0% |
How old are they?
18 - 65 | 100.0% |
What site did they apply to?
Louisiana State University Health Science Center | 100.0% |
What portion of applicants met pre-screening criteria?
Met criteria | 100.0% |
Frequently Asked Questions
How many patients are being treated with this new medication?
"464 volunteers that meet the pre-determined eligibility requirements are necessary to enroll in this study. The trial is being conducted at Parkland Health Center - Farmington in Farmington, Missouri and IHA Hematology Oncology Consultants-Ann Arbor in Ypsilanti, Michigan." - Anonymous Online Contributor
Is this clinical trial being run in multiple locations throughout Canada?
"One hundred different medical facilities are participating in this clinical trial, with locations in Farmington, Ypsilanti, Cape Girardeau, and many other cities. If you enroll, try to pick a centre near you to limit travel." - Anonymous Online Contributor
Are people with the required medical conditions still being accepted into this trial period?
"The information on clinicaltrials.gov indicates that this trial is currently recruiting participants. The trial was originally posted on October 27, 2021 and was last updated on August 12, 2022." - Anonymous Online Contributor
What is the main purpose of Quality-of-Life Assessment?
"Quality-of-Life Assessment is a standard neoplasm metastasis treatment, but can also be useful in managing advanced ovarian cancer, refractory conditions, and advance directives." - Anonymous Online Contributor
Is this the first research project to focus on Quality-of-Life Assessment?
"The first Quality-of-Life Assessment study was completed in 1997 at City of Hope Comprehensive Cancer Center. There have been a total of 1277 such studies completed to date. There are presently 773 clinical trials actively recruiting, a majority of which are based in Farmington, Missouri." - Anonymous Online Contributor