40 Participants Needed

Exercise for Type 2 Diabetes

(GUTFIT Trial)

MS
Overseen ByMartin Senechal, Ph.D.
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: University of New Brunswick
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Approved in 1 JurisdictionThis treatment is already approved in other countries

Trial Summary

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications. However, you must not have changed your diabetes medications in the last three months to be eligible.

What data supports the effectiveness of the treatment Combined Exercise Intervention for Type 2 Diabetes?

Research shows that physical activity is crucial for managing type 2 diabetes, improving blood sugar control, and enhancing quality of life. Exercise therapy is recognized as a key part of treatment, helping to improve heart health and overall fitness in people with type 2 diabetes.12345

Is exercise safe for people with type 2 diabetes?

Exercise is generally safe for people with type 2 diabetes if certain precautions are taken, such as adapting the exercise to individual health conditions and starting slowly. While there is a risk of minor injuries, like muscle strains, serious adverse events are rare when proper screening and gradual progression are followed.678910

How is the Combined Exercise Intervention treatment unique for managing Type 2 Diabetes?

The Combined Exercise Intervention is unique because it integrates both endurance and resistance exercises tailored to individual needs, focusing on improving metabolic control and muscle strength, especially in patients with different stages of Type 2 diabetes. This personalized approach, often supervised, aims to enhance long-term health benefits and compliance, unlike standard treatments that may not offer such customization.311121314

What is the purpose of this trial?

The goal of this experimental trial is to learn about the changes in bacterial diversity in individuals with type 2 diabetes who perform endurance and strength training at different intensities.Participants with type 2 diabetes will be randomly assigned to 16 weeks of either moderate-intensity endurance and strength training or high-intensity endurance and strength training.Researchers will compare the moderate-intensity and high-intensity exercise groups for differences in glycemia and bacterial diversity.

Research Team

MS

Martin Senechal, Ph.D.

Principal Investigator

University of New Brunswick

Eligibility Criteria

Adults aged 19-64 with type 2 diabetes, not very active (less than 10,000 steps per day), stable on their current diabetes medications for the last three months, and have an HbA1c level of at least 7.5%. They should also be falling short of recommended physical activity levels.

Inclusion Criteria

My diabetes medication has been the same for the last 3 months.
I have been diagnosed with type 2 diabetes.
I walk less than 10,000 steps daily on average.
See 3 more

Exclusion Criteria

I have a condition that affects my red blood cells, like sickle cell.
I have a heart condition that makes it unsafe for me to exercise.
I am not on medication that affects heart rate monitor accuracy.
See 5 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo a supervised exercise intervention of resistance and aerobic training for 16 weeks, performed at either high or moderate intensity

16 weeks
Regular supervised exercise sessions

Follow-up

Participants are monitored for changes in glycemic control and gut microbiome diversity after the intervention

4 weeks

Treatment Details

Interventions

  • Combined Exercise Intervention
Trial Overview The trial is testing how different exercise intensities affect gut bacteria and blood sugar control in people with type 2 diabetes. Participants will do either moderate or high-intensity endurance and strength training for 16 weeks to see which is more effective.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: High intensityExperimental Treatment1 Intervention
Participants will perform high-intensity aerobic and strength training exercises.
Group II: Moderate IntensityActive Control1 Intervention
Participants will perform moderate-intensity aerobic and strength training exercises.

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of New Brunswick

Lead Sponsor

Trials
25
Recruited
2,700+

Laval University

Collaborator

Trials
439
Recruited
178,000+

Findings from Research

A study involving 40 newly diagnosed type 2 diabetes patients showed that combining exercise with psychological interventions significantly improved adherence to exercise programs and physiological outcomes compared to exercise alone.
The psychological component not only enhanced immediate results in body fat and strength but also led to better long-term adherence to the exercise regimen, highlighting its importance in managing type 2 diabetes effectively.
Effect of psychological intervention on exercise adherence in type 2 diabetic subjects.Martinus, R., Corban, R., Wackerhage, H., et al.[2006]
Physical activity is a crucial and effective therapy for improving outcomes in patients with type 2 diabetes mellitus (T2DM), yet it is often underutilized due to inadequate emphasis from healthcare professionals.
An effective exercise prescription for T2DM should be personalized, considering the type, frequency, intensity, duration, and progression of activities to ensure safety and optimize patient compliance and health benefits.
Exercise prescription and the patient with type 2 diabetes: a clinical approach to optimizing patient outcomes.Waryasz, GR., McDermott, AY.[2010]
Physical activity is crucial for managing type 2 diabetes, improving metabolic control and quality of life for patients.
Successful physical activity interventions require assessing patients' physical capabilities and motivations, setting clear goals, and regularly adapting plans to fit their needs and support systems.
[Physical activity as a therapeutic tool in type 2 diabetes: practical aspects].Oppert, JM.[2019]

References

Effect of psychological intervention on exercise adherence in type 2 diabetic subjects. [2006]
Exercise prescription and the patient with type 2 diabetes: a clinical approach to optimizing patient outcomes. [2010]
[Physical activity as a therapeutic tool in type 2 diabetes: practical aspects]. [2019]
Exercise therapy in type 2 diabetes. [2021]
Prevention of type II diabetes by physical training. Epidemiological considerations and study methods. [2022]
Prevention of exercise-related injuries and adverse events in patients with type 2 diabetes. [2013]
Screening, safety, and adverse events in physical activity interventions: collaborative experiences from the behavior change consortium. [2022]
Diet and exercise in type 2 diabetes mellitus. [2019]
Adverse events in mobility-limited and chronically ill elderly adults participating in an exercise intervention study supported by general practitioner practices. [2015]
10.United Statespubmed.ncbi.nlm.nih.gov
Revisiting the role of physical activity and exercise in the treatment of type 2 diabetes. [2019]
11.United Statespubmed.ncbi.nlm.nih.gov
Optimizing the therapeutic benefits of exercise in Type 2 diabetes. [2022]
Physical activity and type 2 diabetes: tailoring exercise to optimize fitness and glycemic control. [2010]
[Diabetes, sport and exercise]. [2012]
Effectiveness of combined exercise in people with type 2 diabetes and concurrent overweight/obesity: a systematic review and meta-analysis. [2021]
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top
Terms of Service·Privacy Policy·Cookies·Security