Epitol

Chronic Pain, Bipolar Disorder, Bipolar Disorder + 6 more
Treatment
15 FDA approvals
20 Active Studies for Epitol

What is Epitol

CarbamazepineThe Generic name of this drug
Treatment SummaryCarbamazepine, also called Tegretol, is a medication used to prevent seizures and reduce the pain of trigeminal neuralgia. It was approved by the FDA in 1965 and is also given to treat bipolar disorder. This drug was the first anticonvulsant specifically developed for bipolar disorder.
Tegretolis the brand name
Epitol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tegretol
Carbamazepine
1968
259

Approved as Treatment by the FDA

Carbamazepine, commonly known as Tegretol, is approved by the FDA for 15 uses like Bipolar Disorder and Bipolar Disorder .
Bipolar Disorder
Bipolar Disorder
Pain
Helps manage Pain
Generalized Tonic-Clonic Seizures
Common Cold
Trigeminal Neuralgia
Helps manage Trigeminal Neuralgia (TN)
Bipolar 1 Disorder
Mixed manic depressive episode
Partial-Onset Seizures
Acute Mania
Partial Seizures With Secondary Generalization
Chronic Pain
Helps manage Pain
Trigeminal Neuralgia (TN)
Helps manage Trigeminal Neuralgia (TN)
Seizures
Seizures

Effectiveness

How Epitol Affects PatientsCarbamazepine is a drug used to treat seizures and facial nerve pain. It also has been found to reduce symptoms of mania in people with bipolar disorder. The effects of carbamazepine are specific to the person, and it is important to pay attention to genetic variations as people with a certain gene type (HLA-B*1502) have been found to have a greater risk of serious skin reactions from taking this drug.
How Epitol works in the bodyCarbamazepine works by inhibiting the activity of certain nerve cells and decreasing the pain response to nerve stimulation. It is believed to treat seizure activity and bipolar disorder by increasing dopamine turnover and GABA transmission. However, some people can develop resistance to carbamazepine, which may be due to a variant gene. Recently, a gene promoter has been identified as a potential target to reduce this resistance.

When to interrupt dosage

The proposed dosage of Epitol is contingent upon the determined affliction, including Partial Seizures With Secondary Generalization, Bipolar Disorder and Trigeminal Neuralgia. The measure of dosage is contingent upon the method of delivery as specified in the table underneath.
Condition
Dosage
Administration
Syndrome
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral
Seizures
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral
Common Cold
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral
Trigeminal Neuralgia
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral
Restless Legs Syndrome
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral
Bipolar Disorder
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral
Chronic Pain
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral
Bipolar Disorder
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral
Seizures
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral

Warnings

Epitol has six contraindications, and should be avoided when experiencing the conditions listed in the following table.Epitol Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Bone Marrow
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Carbamazepine may interact with Pulse Frequency
There are 20 known major drug interactions with Epitol.
Common Epitol Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be increased when combined with Carbamazepine.
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Carbamazepine is combined with 2-Methoxyethanol.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Carbamazepine.
5-androstenedione
Major
The metabolism of 5-androstenedione can be increased when combined with Carbamazepine.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
The risk or severity of adverse effects can be increased when Carbamazepine is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Epitol Toxicity & Overdose RiskThe lowest toxic dose of carbamazepine for women is 1920 mg/kg/17W and 54 mg/kg/9D for men. Signs of overdose usually appear 1-3 hours after ingestion and can include rapid heartbeat, high or low blood pressure, twitching muscles, dilated pupils, vomiting, confusion, and difficulty breathing. If you suspect someone has overdosed on carbamazepine, contact the local poison control center and provide supportive treatment. Make sure to monitor their vital signs and keep their airway open. It is also important to consider the potential for overdose due to taking multiple drugs.

Epitol Novel Uses: Which Conditions Have a Clinical Trial Featuring Epitol?

179 active clinical trials are in progress to assess the potential of Epitol in managing Partial Seizures With Secondary Generalization, Trigeminal Neuralgia and Restless Legs Syndrome (RLS).
Condition
Clinical Trials
Trial Phases
Bipolar Disorder
0 Actively Recruiting
Chronic Pain
143 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Seizures
0 Actively Recruiting
Bipolar Disorder
0 Actively Recruiting
Restless Legs Syndrome
2 Actively Recruiting
Not Applicable
Seizures
4 Actively Recruiting
Phase 3, Phase 2
Trigeminal Neuralgia
0 Actively Recruiting
Syndrome
4 Actively Recruiting
Phase 2, Phase 3, Not Applicable
Common Cold
0 Actively Recruiting

Epitol Reviews: What are patients saying about Epitol?

5Patient Review
10/17/2010
Epitol for Facial Nerve Pain
5Patient Review
2/9/2011
Epitol for Bipolar Disorder in Remission
5Patient Review
2/19/2011
Epitol for Convulsive Seizures
I found this medication made me feel very out of it and not at all like myself. It also caused some really strange side effects that were, in my opinion, worse than the issue I was taking it for.
5Patient Review
7/3/2013
Epitol for Facial Nerve Pain
The dosage of 200mg made me feel drowsy and unfocused. I also felt pretty anxious while taking this.
4.7Patient Review
12/25/2012
Epitol for Bipolar I Disorder with Most Recent Episode Mixed
I was on epitol for six months and it made me feel nauseous the whole time. I also had non-stop sneezing, watery eyes, and heartburn. Thankfully, I was recently taken off the medication and I feel so much better now. No more discomfort and I can breathe through my nose again!
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about epitol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Epitol the same as carbamazepine?

"Carbamazepine is an anticonvulsant and analgesic that is indicated to treat partial seizures with complex symptomatology (psychomotor, temporal lobe), generalized tonic-clonic seizures (grand mal), and mixed seizure patterns which include the above, or other partial or generalized seizures."

Answered by AI

What is Epitol used for?

"This medication is an anticonvulsant, which means it is used to prevent seizures. It is also used to relieve certain types of nerve pain, such as trigeminal neuralgia. This medication works by reducing the spread of seizure activity in the brain and restoring the normal balance of nerve activity."

Answered by AI

What are the side effects of Epitol?

"There are a few potential side effects associated with this medication including dizziness, drowsiness, constipation, dry mouth, unsteadiness, nausea, and vomiting."

Answered by AI

Clinical Trials for Epitol

Have you considered Epitol clinical trials? We made a collection of clinical trials featuring Epitol, we think they might fit your search criteria.
Have you considered Epitol clinical trials? We made a collection of clinical trials featuring Epitol, we think they might fit your search criteria.
Have you considered Epitol clinical trials? We made a collection of clinical trials featuring Epitol, we think they might fit your search criteria.
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