180 Participants Needed

NeuroCuple Device for Pain

MC
AS
Overseen ByAntonio Saad, MD
Age: 18+
Sex: Female
Trial Phase: Academic
Sponsor: Inova Health Care Services
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial examines a new device called the NeuroCuple to help manage pain after a cesarean delivery. Researchers aim to determine if this device can reduce the need for opioid pain medicine compared to usual care. Participants will either use the NeuroCuple device, a sham device (which looks like the treatment but does nothing), or receive standard care without any device. Women eligible for this trial are those scheduled for a non-emergency C-section and who do not have chronic pain or skin conditions that could affect device use. As an unphased trial, this study offers participants the chance to contribute to innovative pain management research.

Will I have to stop taking my current medications?

The trial information does not specify if you need to stop taking your current medications. However, if you are a chronic opioid user or have active drug abuse, you would not be eligible to participate.

What prior data suggests that the NeuroCuple device is safe for managing postoperative pain in females undergoing cesarean delivery?

Research shows that the NeuroCuple™ device could safely manage post-surgical pain. Studies suggest it might reduce the need for opioid pain medications, decreasing the risk of opioid-related side effects. Previous data indicates that patients generally tolerate the device well, with no major side effects reported. The NeuroCuple device operates without drugs, relying on non-medication methods for effectiveness. Thus far, it appears to be a promising option for managing pain without the usual medication risks.12345

Why are researchers excited about this trial?

Researchers are excited about the NeuroCuple Device because it offers a non-invasive approach to managing pain, specifically designed for post-partum recovery. Unlike standard treatments that often rely on medications like NSAIDs or opioids, which can have side effects and pose risks for new mothers, the NeuroCuple Device uses a novel mechanism to potentially alleviate pain without drugs. This device works by being placed in the PACU (Post Anesthesia Care Unit), possibly providing immediate relief as mothers transition to the post-partum unit. Its drug-free nature and the potential for immediate effect make it a promising alternative to traditional pain management methods.

What evidence suggests that the NeuroCuple device is effective for managing postoperative pain after cesarean delivery?

Research has shown that the NeuroCuple device, which participants in this trial may receive, could help manage pain after surgery. One study reduced the number of patients needing opioids by 9%. Another study found it decreased the need for opioid refills by 47% in the first month after surgery. Patients using the device also reported feeling 34% less pain while resting. These results suggest that the NeuroCuple device might help lessen pain and reduce the need for opioids after a cesarean delivery.12678

Who Is on the Research Team?

AS

Antonio Saad, MD

Principal Investigator

Inova Health Care Services

Are You a Good Fit for This Trial?

This trial is for women undergoing cesarean delivery who may benefit from a new non-pharmacological analgesic device called NeuroCuple™. The study aims to see if this device can reduce pain and the need for opioid medication after surgery.

Inclusion Criteria

I am a woman over 18 and can consent in English or Spanish.
I am scheduled for a C-section with spinal or epidural anesthesia.
The skin around my surgery cut is healthy and unbroken.
See 1 more

Exclusion Criteria

Active drug abuse
Chronic opioid user
Subject is concurrently participating in another research study with an investigational drug or medical device that in the Investigator's opinion could impact subject safety or study results
See 5 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

Preoperative period

Treatment

Participants receive either the NeuroCuple device, a sham device, or standard care for postoperative pain management

4 days
Daily monitoring while inpatient and until postoperative day 4

Follow-up

Participants are monitored for pain scores, opioid intake, and quality of recovery

4 days

What Are the Treatments Tested in This Trial?

Interventions

  • NeuroCuple Device
  • Sham
Trial Overview The study tests the effectiveness of the NeuroCuple™ device in managing postoperative pain compared to a sham (placebo-like) treatment. Participants will be randomly assigned to one of three groups, with two receiving different levels of NeuroCuple intervention and one receiving sham treatment.
How Is the Trial Designed?
3Treatment groups
Active Control
Placebo Group
Group I: Standard of careActive Control1 Intervention
Group II: NeuroCuple deviceActive Control1 Intervention
Group III: Sham devicePlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Inova Health Care Services

Lead Sponsor

Trials
80
Recruited
22,700+

nCap Medical

Industry Sponsor

Trials
3
Recruited
290+

Citations

Role of the NeuroCuple™ Device for the Postoperative Pain ...Conclusions: Our data suggest that the NeuroCuple™ device may be an effective non-pharmacological alternative to opioids to manage ...
NEUROCUPLE™ in TKA Patients to Enhance Pain ...This is a randomized (1:1) placebo-controlled clinical trial to determine the feasibility and effectiveness of 30-day application of NEUROCUPLE™ patch for ...
NIDA Funds Investigation of Innovative Device to Enhance ...Preliminary data from the pilot study showed that the NEUROCUPLE™ device reduced opioid refills by 47% in the first 30 days post-surgery. The newly funded NIDA ...
4.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/38068446/
Role of the NeuroCuple™ Device for the Postoperative ...Opioid consumption was reduced by 9%. More importantly, use of the NeuroCuple™ devices reduced the number of patients requesting an opioid ...
Outcomes in the NeuroCuple™ treatment group compared ...When used in patients receiving a unilateral total knee or total hip arthroplasty, NeuroCuple TM was associated with a significant 34% reduction in pain at rest ...
Impact of the NeuroCuple Device on Pain Management ...In this study, the investigators will examine total milligram morphine equivalent (MME) opioid intake at postoperative day 4 or before discharge as the primary ...
Impact of the NeuroCuple Device on Pain Management ...The investigators hypothesize that women treated with the Neurocuple device will experience less pain and consequently require less opioid pain ...
Use of Nanotechnology as an Alternative to Opioids for ...Conclusion: Our report suggests that the use of the NeuroCuple™ device may represent an interesting alternative to opioids for the peri-operative management of ...
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