300 Participants Needed

Ethyl Chloride Spray for Pain Management

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Overseen ByJennifer M Wolf, MD, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Chicago
Must be taking: Corticosteroids

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests whether ethyl chloride spray can reduce pain during corticosteroid injections for conditions like osteoarthritis and tendinitis. The goal is to determine if the spray can make the injection process less uncomfortable by numbing the area. Participants will be divided into groups: some will receive the ethyl chloride spray, others a placebo spray, and some no spray at all before their injection. Individuals who have never had a corticosteroid injection and are receiving one in their arm or leg might be suitable for this trial. As an unphased trial, this study offers a unique opportunity to contribute to research that could enhance patient comfort during medical procedures.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that Ethyl Chloride Spray is safe for pain management?

Previous studies have used ethyl chloride spray to quickly numb the skin. Research has shown it is generally safe when used correctly. However, ethyl chloride is flammable, so it must be kept away from open flames or anything that might spark.

Reports of serious side effects from using the spray are rare. Most people experience no problems, though some might feel a slight burning or stinging upon application. It is also important to use it in a well-ventilated area to avoid inhaling too much of the spray.

Overall, ethyl chloride spray is considered safe for numbing when safety instructions are followed carefully.12345

Why are researchers excited about this trial?

Researchers are excited about using ethyl chloride spray for pain management because it offers a quick and non-invasive way to reduce pain during orthopedic injections. Unlike oral pain medications that can take time to kick in, ethyl chloride acts almost instantly by cooling the skin and numbing the area. This makes it especially appealing for those who want to avoid needles or deeper interventions. Additionally, its use as a spray makes it easy to apply and highly accessible in various clinical settings.

What evidence suggests that Ethyl Chloride Spray is effective for pain management during orthopaedic injections?

Research has shown that ethyl chloride spray, which participants in this trial may receive, effectively reduces pain at injection sites. One study found it more effective than EMLA cream, a common numbing agent. Another study demonstrated that ethyl chloride significantly reduced pain compared to a placebo. By numbing the skin's surface, ethyl chloride spray can make needle procedures, such as those for orthopedic treatments, less uncomfortable. This makes it a promising option for reducing patient anxiety and discomfort during these treatments.678910

Are You a Good Fit for This Trial?

This trial is for individuals getting their first corticosteroid injection in an arm or leg, including soft tissue and joint injections. It's aimed at those who may have a fear of doctors, needle phobia, or concerns about pain management.

Inclusion Criteria

I am 18 years old or older.
I am getting my first corticosteroid injection in an arm or leg.

Exclusion Criteria

Patients with previous injection experiences

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive corticosteroid injections with or without freeze spray to evaluate its efficacy in reducing discomfort

1 day
1 visit (in-person)

Follow-up

Participants are monitored for pain and anxiety levels immediately after the injection

10 minutes
1 visit (in-person)

Long-term Follow-up

Participants' overall status and satisfaction with the treatment are assessed

1 week

What Are the Treatments Tested in This Trial?

Interventions

  • Ethyl Chloride Spray
Trial Overview The study tests whether Ethyl Chloride spray can reduce discomfort during corticosteroid injections compared to a Cold Saline Spray. The goal is to see if it helps with the anxiety and pain associated with needle procedures.
How Is the Trial Designed?
3Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Freeze spray groupExperimental Treatment1 Intervention
Group II: No spray prior to injectionActive Control1 Intervention
Group III: Placebo application of cold saline sprayPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Chicago

Lead Sponsor

Trials
1,086
Recruited
844,000+

Citations

Ethyl chloride spray for injection site analgesiaEthyl chloride was more effective than EMLA cream at reduction in pain overall. Patients in group 3 rated pain lower with use of ethyl chloride ...
Ethyl chloride spray, a local anesthetic in arterial blood gas ...The analgesic efficacy of ethyl chloride spray in reducing pain was statistically significantly higher compared to the placebo (p = 0.000).
Study Details | NCT06651788 | Does Ethyl Chloride Spray ...By numbing the injection site superficially, freeze sprays offer the potential to mitigate patient discomfort during corticosteroid injections, thus improving ...
Use and Effectiveness of Ethyl Chloride for Hand InjectionsWe hypothesize that ethyl chloride spray imparts no benefit to patients' perception of pain or anxiety for routine hand injections. Methods. We first surveyed ...
Comparison of the Effectiveness between 5% Eutectic ...Conclusion: Patients scheduled for an endoscopic procedure did not showed significant pain relief with either the 5% eutectic mixture of local anesthetic cream ...
Ethyl Chloride - Instant Topical Anesthetic SprayEthyl chloride is FLAMMABLE and should never be used in the presence of an open flame or electrical cautery equipment. Use in a well-ventilated area.
Ethyl Chloride SprayEthyl chloride is FLAMMABLE and should never be used in the presence of an open flame or electrical cautery equipment. Use in a well-ventilated area.
Ethyl Chloride Spray, Non-Aerosol - Uses, Side Effects, ...This medication is flammable. Do not use near an open flame or near electrical equipment that can spark a fire. Before applying ethyl chloride to injection and ...
Gebauer's Ethyl ChlorideGebauer Company has executed the following performance testing to verify that. Gebauer's Ethyl Chloride provides a safe and effective product. Number of ...
May 7, 2019 Gebauer Company Brittney Cooper Sr ...Gebauer's Ethyl Chloride Topical Anesthetic Spray is a prescription device designed to deliver ethyl chloride in a mist, fine or medium spray.
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