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tACS for Neuropathic Pain After SCI

N/A

Waitlist Available

Led By Sheng Li, MD, Ph.D

Research Sponsored by The University of Texas Health Science Center, Houston

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patient has neuropathic pain after traumatic spinal cord injury or amputation or brain injury

Patient is between 18 to 75 years of age

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change of hrv 10-15 minutes before and after the tacs intervention will be measured.

Awards & highlights

Study Summary

This trial tests a new treatment for pain relief in people with spinal cord injuries.

Who is the study for?

This trial is for individuals aged 18-75 who have neuropathic pain following a traumatic spinal cord injury, amputation, or brain injury and have been stable on oral pain medications for at least two weeks. It's not suitable for those with pacemakers, metal implants, unstable medical conditions, non-neuropathic pain like inflammation from surgery wounds, arm amputations, psychiatric disorders currently adjusting their pain meds or with substance abuse issues.Check my eligibility

What is being tested?

The study tests the effectiveness of transcranial alternating current stimulation (tACS) in managing neuropathic pain after spinal cord injuries. Participants will receive either a sham (fake) treatment or real tACS at different frequencies (10Hz or 20Hz) to see if there's an improvement in their pain levels.See study design

What are the potential side effects?

While the specific side effects of tACS are not detailed here, similar treatments can sometimes cause mild headaches, tingling sensations on the scalp during application, fatigue shortly after treatment sessions and discomfort due to muscle contractions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have nerve pain from a spinal cord injury, amputation, or brain injury.

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I am between 18 and 75 years old.

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I have been experiencing pain for more than 3 months.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change of hrv 10-15 minutes before and after the tacs intervention will be measured.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change of hrv 10-15 minutes before and after the tacs intervention will be measured.

This trial's timeline: 3 weeks for screening, Varies for treatment, and change of hrv 10-15 minutes before and after the tacs intervention will be measured. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Heart rate variability (HRV) measurement

Pain scale (visual analogue scale, VAS) measurement

Trial Design

3Treatment groups

Experimental Treatment

Group I: "tACS Sham, tACS 10Hz, tACS 20Hz" experimental orderExperimental Treatment3 Interventions

tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns. tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns. tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns.

Group II: "HD-tACS 20Hz, HD-tACS 10Hz, HD-tACS Sham" experimental orderExperimental Treatment3 Interventions

tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns. tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns. tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns.

Group III: "HD-tACS 10Hz, HD-tACS 20Hz, HD-tACS Sham" experimental orderExperimental Treatment3 Interventions

tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns. tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns. tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns.

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

The University of Texas Health Science Center, HoustonLead Sponsor

903 Previous Clinical Trials

320,963 Total Patients Enrolled

2 Trials studying Neuropathic Pain

120 Patients Enrolled for Neuropathic Pain

Sheng Li, MD, Ph.DPrincipal InvestigatorThe University of Texas Health Science Center, Houston

1 Previous Clinical Trials

14 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who can qualify to participate in this clinical investigation?

"Patients between 18 and 75 with neuropathic pain can enroll in this clinical trial, which is currently open to a maximum of 14 applicants."

Answered by AI

Is this medical experiment currently enlisting volunteers?

"As indicated on clinicaltrials.gov, this medical trial is no longer recruiting participants; the last updated date recorded was August 31st 2023. Nevertheless, 132 other studies are currently in search of volunteers at this time."

Answered by AI