Web-based Aerobic Exercise Program for Brain Cancer
Phase-Based Progress Estimates
Effectiveness
Safety
The Hospital for Sick Children, Toronto, Canada
Brain Cancer+2 More
Web-based Aerobic Exercise Program - BehavioralEligibility
< 65
All Sexes
What conditions do you have?
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Eligibility
< 65
All Sexes
What conditions do you have?
Select
Study Summary
The study will assess the feasibility of a pilot clinical trial of community-led aerobic exercise training for paediatric brain tumour survivors (PBTS) and the feasibility of a web-based platform to deliver this exercise training. It is hypothesized that 12 weeks of community-led exercise training will be feasible for PBTS and the web-based platform will be feasible to deliver exercise training by community-based instructors.
Eligible Conditions
- Brain Cancer
- Brain Neoplasms
- Cognitive Impairment (CI)
Treatment Effectiveness
Effectiveness Progress
Study Objectives
7 Primary · 0 Secondary · Reporting Duration: 24 Months
24 Months
Feasibility of the exercise program: The probability that 30 eligible patients will be recruited
24 weeks
Feasibility of the exercise program: The probability that a recruited participant will attend ≥60% of exercise training sessions
Feasibility of the exercise program: The probability that a recruited participant will complete all study procedures
Feasibility of the exercise program: The probability that instructors will adhere to the web-based platform to deliver exercise training
Feasibility of the web-based platform: The probability that instructors will rate the platform as acceptable
Feasibility of the web-based platform: The probability that instructors will rate the platform as efficient
Feasibility of the web-based platform: The probability that instructors will rate the platform as relevant
Week 25
Comparison of community-led exercise training to historical data from a hospital-led exercise training program: Changes in cardiovascular fitness (heart rate, and sub-maximal and maximal work rates)
Comparison of community-led exercise training to historical data from a hospital-led exercise training program: Changes in controlled attention
Comparison of community-led exercise training to historical data from a hospital-led exercise training program: Changes in declarative memory
Comparison of community-led exercise training to historical data from a hospital-led exercise training program: Changes in information processing speed
Comparison of community-led exercise training to historical data from a hospital-led exercise training program: Changes in physical functioning (bilateral coordination and balance, and running speed/agility and strength)
Comparison of community-led vs. historical hospital-led exercise training program: Changes in hippocampal volume
Comparison of community-led vs. historical hospital-led exercise training program: Changes in neural communication
Impact of this study intervention on PBTS: Changes in MEG behavioural measures
Impact of this study intervention on PBTS: Changes in cardiovascular fitness (heart rate, and sub-maximal and maximal work rates)
Impact of this study intervention on PBTS: Changes in controlled attention
Impact of this study intervention on PBTS: Changes in declarative memory
Impact of this study intervention on PBTS: Changes in full scale intelligence
Impact of this study intervention on PBTS: Changes in hippocampal volume
Impact of this study intervention on PBTS: Changes in information processing speed
Impact of this study intervention on PBTS: Changes in neural communication
Impact of this study intervention on PBTS: Changes in physical functioning (bilateral coordination and balance, and running speed/agility and strength, and ataxia)
Impact of this study intervention on PBTS: Changes in white matter microstructure
Impact of this study intervention on PBTS: Health and QOL
Trial Safety
Safety Progress
Trial Design
1 Treatment Group
FitABCS exercise
1 of 1
Experimental Treatment
30 Total Participants · 1 Treatment Group
Primary Treatment: Web-based Aerobic Exercise Program · No Placebo Group · N/A
FitABCS exercise
Behavioral
Experimental Group · 1 Intervention: Web-based Aerobic Exercise Program · Intervention Types: BehavioralTrial Logistics
Trial Timeline
Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 24 months
Closest Location: The Hospital for Sick Children · Toronto, Canada
2014First Recorded Clinical Trial
0 TrialsResearching Brain Cancer
401 CompletedClinical Trials
Who is running the clinical trial?
The Hospital for Sick ChildrenLead Sponsor
635 Previous Clinical Trials
6,815,884 Total Patients Enrolled
Donald J MabbottPrincipal InvestigatorThe Hospital for Sick Children
Eligibility Criteria
Age < 65 · All Participants · 7 Total Inclusion Criteria
Mark “yes” if the following statements are true for you:You have a diagnosis of celiac disease at least 15 years after onset of symptoms.
You are in remission as determined by a permanent SickKids staff Neuro-Oncologist.
You must have a minimum of two years of schooling in English at the time of your first assessment.
You have a parent or legal guardian willing to complete the Health and Quality of Life measures.
Informed consent (and assent, where applicable) will be obtained from the participants and/or their legal guardians.
About The Reviewer
Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.
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Conditions
Cancer Related
Treatments