40 Participants Needed

Aerobic Exercise for Brain Tumor Survivors

(Fit ABCS Trial)

DJ
Cd
Overseen ByCynthia de Medeiros, M.Sc.
Age: < 65
Sex: Any
Trial Phase: Academic
Sponsor: The Hospital for Sick Children
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial will test if a community-led exercise program using an online system is practical for children who have survived brain tumors. The kids will join group exercise sessions to help improve their fitness by keeping their heart rates up.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your doctor.

Is aerobic exercise safe for brain tumor survivors?

Research shows that aerobic exercise programs, including those supervised and web-based, are generally safe for brain tumor survivors, with no reported adverse effects in studies involving both children and adults.12345

How is the Web-based Aerobic Exercise Program unique for brain tumor survivors?

This treatment is unique because it offers a web-based, community-led aerobic exercise program specifically designed for brain tumor survivors, focusing on improving physical function and mental health, which are often neglected in traditional treatments.23467

What data supports the effectiveness of the treatment Web-based Aerobic Exercise Program for brain tumor survivors?

Research shows that exercise can improve physical function and mental health in brain cancer survivors, with studies indicating benefits like better fitness, reduced depression, and improved quality of life. Exercise programs have been well-tolerated and beneficial in other cancer populations, suggesting they could be helpful for brain tumor survivors too.23478

Who Is on the Research Team?

DJ

Donald Mabbott, PhD

Principal Investigator

The Hospital for Sick Children

Are You a Good Fit for This Trial?

This trial is for children aged 6 to under 18 who have had a brain tumor, are in remission, and can understand English. They must be at least one year post-diagnosis but not more than fifteen years. A parent or guardian must agree to participate in health assessments. Kids with certain conditions, metal implants, recent cognitive therapy, or those pregnant cannot join.

Inclusion Criteria

I have been diagnosed with a brain tumor.
My condition is stable as confirmed by a SickKids staff Neuro-Oncologist.
I am between 6 and 17 years old.
See 4 more

Exclusion Criteria

Have a programmable shunt
I haven't had any brain training therapy in the last 3 months.
I need medicine to help me stay calm for brain scans.
See 5 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo 12 weeks of community-led aerobic exercise training, involving 90-minute group sessions 3 times per week.

12 weeks
36 sessions (in-person)

Follow-up

Participants are monitored for changes in physical functioning, brain structure, and cognitive outcomes at 3-month follow-up.

12 weeks
2 visits (in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • Web-based Aerobic Exercise Program
Trial Overview The study tests if a web-based aerobic exercise program led by community instructors is doable for young brain tumor survivors over 12 weeks. It aims to see if this online platform works well for delivering the training.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: FitABCS exerciseExperimental Treatment1 Intervention
Web-based community-led, 12-week exercise program
Group II: FitABCS controlActive Control1 Intervention
Healthy control

Find a Clinic Near You

Who Is Running the Clinical Trial?

The Hospital for Sick Children

Lead Sponsor

Trials
724
Recruited
6,969,000+

Published Research Related to This Trial

A controlled clinical trial involving 28 children who survived brain tumors showed that exercise training significantly improved physical functioning, particularly in bilateral coordination, with benefits lasting up to 12 weeks after training ended.
Participants in group training settings also experienced increased cardiopulmonary fitness, as indicated by improved work rates, highlighting the effectiveness of structured exercise programs for this vulnerable population.
Exercise training improves physical function and fitness in long-term paediatric brain tumour survivors treated with cranial irradiation.Piscione, PJ., Bouffet, E., Timmons, B., et al.[2018]
Cancer survivors prefer exercise programs supervised by specialists who understand cancer, and they value support from healthcare providers and accessible community locations, as identified in a study with 13 survivors and 5 caregivers before the ACE trial.
After participating in the ACE trial, survivors expressed a need for better exercise counseling from healthcare providers and suggested that exercise should be introduced earlier in their care, highlighting gaps in support that could improve their recovery.
A Practical Approach to Using Integrated Knowledge Translation to Inform a Community-Based Exercise Study.Suderman, K., Dolgoy, N., Yurick, J., et al.[2021]
A 12-week structured exercise program was well tolerated by two female brain cancer patients, with no adverse effects reported, indicating that exercise can be safely integrated into their treatment plans.
Both participants showed significant improvements in physical strength, cardiovascular fitness, and psychological well-being, including reduced anxiety and depression, suggesting that exercise may enhance quality of life for brain cancer survivors.
Exercise Improves Physical Function and Mental Health of Brain Cancer Survivors: Two Exploratory Case Studies.Levin, GT., Greenwood, KM., Singh, F., et al.[2018]

Citations

Exercise training improves physical function and fitness in long-term paediatric brain tumour survivors treated with cranial irradiation. [2018]
A Practical Approach to Using Integrated Knowledge Translation to Inform a Community-Based Exercise Study. [2021]
Exercise Improves Physical Function and Mental Health of Brain Cancer Survivors: Two Exploratory Case Studies. [2018]
Randomized trial of exercise and an online recovery tool to improve rehabilitation outcomes of cancer survivors. [2018]
Therapeutic exercise interventions in pediatric survivors of brain cancer and other solid tumors: A scoping review. [2023]
Design and methods of a randomized telehealth-based intervention to improve fitness in survivors of childhood cancer with exercise intolerance. [2023]
Design and Evaluation of an Outdoor Exercise Program for Pediatric Cancer Survivors. [2022]
Conceptual development of an intensive exercise program for glioma patients (ActiNO): summary of clinical experience. [2023]
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