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KMO Inhibitor

Diclofenac for Alcohol Use Disorder (DKMOI Trial)

Phase < 1
Waitlist Available
Led By Daniel Roche, PhD
Research Sponsored by University of Maryland, Baltimore
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Ages 21-65
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0-, 60-, 120-, 180-, and 240-minutes after pill administration
Awards & highlights

DKMOI Trial Summary

This trial tests if diclofenac (100mg) can help people with AUD by increasing their kynurenic acid levels. The effects are tested in 2 sessions with a placebo.

Who is the study for?
This trial is for individuals aged 21-65 with Alcohol Use Disorder (AUD) of any severity, who are not pregnant or nursing, and do not use certain drugs. Participants must not be on medications that interact with diclofenac, seeking AUD treatment, or have had recent substance abuse other than alcohol and nicotine.Check my eligibility
What is being tested?
The study tests if a single dose of diclofenac (100 mg) can increase kynurenic acid levels in the blood compared to a placebo. This could show whether diclofenac inhibits an enzyme related to AUD. The process is randomized and double-blind.See study design
What are the potential side effects?
Diclofenac may cause side effects like digestive issues (nausea, vomiting), headaches, dizziness, skin reactions, liver function changes, and increased risk of heart attack or stroke. It's important to monitor for these during the trial.

DKMOI Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 21 and 65 years old.

DKMOI Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0-, 60-, 120-, 180-, and 240-minutes after pill administration
This trial's timeline: 3 weeks for screening, Varies for treatment, and 0-, 60-, 120-, 180-, and 240-minutes after pill administration for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Kynurenic Acid

DKMOI Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: DiclofenacActive Control1 Intervention
Participants will take a single 100mg dose of diclofenac.
Group II: PlaceboPlacebo Group1 Intervention
Participants will take a single dose of placebo.

Find a Location

Who is running the clinical trial?

University of Maryland, BaltimoreLead Sponsor
688 Previous Clinical Trials
374,644 Total Patients Enrolled
7 Trials studying Alcoholism
583 Patients Enrolled for Alcoholism
Daniel Roche, PhDPrincipal InvestigatorUniversity of Maryland, Baltimore
3 Previous Clinical Trials
83 Total Patients Enrolled
3 Trials studying Alcoholism
83 Patients Enrolled for Alcoholism

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrolment currently open for this experiment?

"This trial, which was initially posted on November 1st 2023 and last updated August 31st of that same year, is not accepting new patients. Nevertheless, the clinicaltrials.gov website lists 381 other studies that are presently seeking participants."

Answered by AI

Who meets the prerequisites for participation in this trial?

"This clinical trial has a quota of 12 people and requires that applicants have an alcohol addiction. The age range for accepted participants is between 21 to 65 years old."

Answered by AI

Are individuals of 85 years or younger accepted into the research?

"This trial has strict age requirements; the lower limit is 21 years old while the upper boundary is 65."

Answered by AI

Who else is applying?

What site did they apply to?
Maryland Psychiatric Research Center (MPRC) Treatment Research Program (TRP)
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Diclofenac as a KMO Inhibitor
2024. "Diclofenac as a KMO Inhibitor". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06029296.
~8 spots leftby Dec 2024
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