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Polyphenol

Curcumin for Renal Transplant Health

N/A

Waitlist Available

Led By Pierpaolo Di Cocco, MD, PhD

Research Sponsored by University of Illinois at Chicago

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

The subject is a recipient of a living donor or deceased donor kidney only transplant

The subject is > 18 years of age

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 12 months

Awards & highlights

Study Summary

This trial will investigate whether curcumin can improve vascular function and cognitive impairment in kidney transplant recipients.

Who is the study for?

This trial is for adults over 18 who have received a kidney transplant from either a living or deceased donor. It's not open to those who've had multiple organ transplants or were taking curcumin before their kidney transplant.Check my eligibility

What is being tested?

The study is testing if curcumin can help improve blood vessel function and brain health in people who have had a kidney transplant, comparing it with a placebo (a substance with no therapeutic effect).See study design

What are the potential side effects?

While the document doesn't specify side effects, generally, curcumin may cause digestive upset, headache, rash and yellow stool; however, most people tolerate it well.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have received a kidney transplant from a living or deceased donor.

Select...

I am older than 18 years.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 12 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~12 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Cognitive function & Pain

Graft Outcomes

Inflammation and oxidative stress

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Curcumin Arm (Arm 1)Experimental Treatment1 Intervention

20 subjects will be randomized (1:1) to this arm and receive curcumin for a year. In addition, subjects will have four study visits at Day 0, and 3, 6 and 12 months post-transplant. These study visits also include blood samples and questionnaires.

Group II: Placebo Arm (Arm 2)Placebo Group1 Intervention

20 subjects will be randomized (1:1) to this arm and receive placebo for a year. In addition, subjects will have four study visits at Day 0, and 3, 6 and 12 months post-transplant. These study visits also include blood samples and questionnaires.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Curcumin

2017

Completed Phase 4

~1050

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Illinois at ChicagoLead Sponsor

607 Previous Clinical Trials

1,559,341 Total Patients Enrolled

Verdure SciencesIndustry Sponsor

4 Previous Clinical Trials

72 Total Patients Enrolled

Pierpaolo Di Cocco, MD, PhDPrincipal InvestigatorUniversity of Illinois at Chicago

Media Library

Curcumin (Polyphenol) Clinical Trial Eligibility Overview. Trial Name: NCT03935958 — N/A

Renal Transplant Disorder Research Study Groups: Curcumin Arm (Arm 1), Placebo Arm (Arm 2)

Renal Transplant Disorder Clinical Trial 2023: Curcumin Highlights & Side Effects. Trial Name: NCT03935958 — N/A

Curcumin (Polyphenol) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03935958 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To what extent is participation in this investigation reaching?

"That is correct. The information on clinicaltrials.gov demonstrates that this trial, which was initially published November 1st 2019, is presently accepting applicants. Twenty patients are needed at a single medical facility for the study to reach completion."

Answered by AI

Has recruitment begun for this experiment yet?

"Affirmative. Clinicaltrials.gov provides evidence that this investigation, which was announced on November 1st 2019, is in need of participants. 20 individuals must be recruited from a single medical centre."

Answered by AI

Recent research and studies

TransplantationJournal

Beneficial Effects of the Bioflavonoids Curcumin and Quercetin on Early Function in Cadaveric Renal Transplantation: A Randomized Placebo Controlled Trial

Shoskes, Daniel, Chantale Lapierre, Marcia Cruz-Corerra, Nicolas Muruve, Reinaldo Rosario, Beth Fromkin, Mauro Braun, and John Copley. 2005. “Beneficial Effects of the Bioflavonoids Curcumin and Quercetin on Early Function in Cadaveric Renal Transplantation: A Randomized Placebo Controlled Trial”. Transplantation. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/01.tp.0000183290.64309.21.

Basic & Clinical Pharmacology & ToxicologyJournal

Curcumin Ameliorates Kidney Function and Oxidative Stress in Experimental Chronic Kidney Disease

Ali, Badreldin H., Suhail Al-Salam, Yousuf Al Suleimani, Jamila Al Kalbani, Shadia Al Bahlani, Mohammed Ashique, Priyadarsini Manoj, et al.. 2017. “Curcumin Ameliorates Kidney Function and Oxidative Stress in Experimental Chronic Kidney Disease”. Basic & Clinical Pharmacology & Toxicology. Wiley. doi:10.1111/bcpt.12817.

BioMed Research InternationalJournal

Recent Advances of Curcumin in the Prevention and Treatment of Renal Fibrosis

Sun, Xuejiao, Yi Liu, Cheng Li, Xiting Wang, Ruyuan Zhu, Chenyue Liu, Haixia Liu, et al.. 2017. “Recent Advances of Curcumin in the Prevention and Treatment of Renal Fibrosis”. Biomed Research International. Hindawi Limited. doi:10.1155/2017/2418671.

clinicaltrials.govStudy