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What is Prefest
NorgestimateThe Generic name of this drug
Treatment SummaryEstradiol is a hormone naturally produced by females. It is used in hormone therapy to treat conditions caused by low estrogen levels, such as hot flashes and vaginal atrophy. Estradiol is available in various forms including oral tablets, injections, vaginal rings, patches, sprays, gels, and creams. For oral or injection use, estradiol is often combined with an ester side-chain, such as ethinyl estradiol (EE), to increase its bioavailability. EE is the synthetic form of estradiol and is commonly used in oral contraceptive pills (OCPs).
Ortho Tri Cyclenis the brand name
Prefest Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ortho Tri Cyclen
Norgestimate
1989
113
Approved as Treatment by the FDA
Norgestimate, commonly known as Ortho Tri Cyclen, is approved by the FDA for 8 uses which include moderate Menopausal Vasomotor Symptoms and Postmenopausal Osteoporosis .moderate Menopausal Vasomotor Symptoms
Used to treat moderate Menopausal Vasomotor Symptoms in combination with Estradiol
Postmenopausal Osteoporosis
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
Acne Vulgaris
Used to treat moderate Acne vulgaris in combination with Ethinylestradiol
Hot flashes
Used to treat Menopause in combination with Estradiol
Menopause
Used to treat severe Vasomotor Symptoms Associated With Menopause in combination with Estradiol
severe menopausal vulvovaginal atrophy
Used to treat severe menopausal vulvovaginal atrophy in combination with Estradiol
moderate Vulvovaginal atrophy
Used to treat moderate Vulvovaginal atrophy in combination with Estradiol
Oral Contraceptives
Used to treat Oral Contraceptives in combination with Ethinylestradiol
Effectiveness
How Prefest Affects PatientsEstradiol helps to reduce hot flashes and other menopausal symptoms, as well as improve vaginal dryness and pain during sex. It also helps to increase bone density, improve the balance of fats in the blood, and reduce levels of follicle-stimulating hormone. However, it can cause a higher risk of cardiovascular issues like strokes, DVT, and hypertension. Estradiol can also induce a hyper-coagulable state, which is a state of increased risk of forming blood clots. The increased risk of hypertension is thought to be caused by increased levels of angiotensin and sodium retention.
How Prefest works in the bodyEstrogen is a hormone found in many parts of the body, including the breasts, uterus, ovaries, skin, prostate, bones, fat, and brain. During the reproductive years, the ovaries produce most of the estrogen in a woman's body. After menopause, the main source of estrogen is from a hormone made in the adrenal glands called androstenedione. This hormone is converted to estrone and its sulfate form, estrone sulfate. These two forms are the most common estrogens found in postmenopausal women.
Estradiol is more powerful than estrone and
When to interrupt dosage
The suggested measure of Prefest is contingent upon the diagnosed condition, for example Premature Menopause, Pharmaceutical Preparations and Postmenopause. The amount of dosage is contingent upon the technique of administration featured in the following table.Condition
Dosage
Administration
Hot flashes
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
severe menopausal vulvovaginal atrophy
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Hypermenorrhea
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
moderate Vulvovaginal atrophy
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Hirsutism
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Menopause
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Menstrual Distress (Dysmenorrhea)
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
moderate Menopausal Vasomotor Symptoms
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Postmenopausal Osteoporosis
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Oral Contraceptives
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Acne Vulgaris
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Polycystic Ovarian Syndrome
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Warnings
Prefest has eighteen contraindications and must not be combined with the circumstances enumerated in the following table.Prefest ContraindicationsCondition
Risk Level
Notes
Breast
Do Not Combine
Breast Cancer
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Hypersensitivity
Do Not Combine
high risk of venous thrombotic disease
Do Not Combine
Pulse Frequency
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
Metrorrhagia
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
Common Prefest Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Norgestimate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Norgestimate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Norgestimate.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Norgestimate.
Astemizole
Major
The metabolism of Astemizole can be increased when combined with Norgestimate.
Prefest Toxicity & Overdose RiskLong-term exposure to estradiol has been shown to have toxic effects at a dose of 0.003mg/kg/day in rats. The lowest toxic dose for women is 21mg/kg/21D and the highest dose that can cause death is 960mg/kg. An overdose of estradiol may cause symptoms such as nausea, vomiting, abdominal pain, breast tenderness, blood clots, and vaginal bleeding. It is advised to stop taking estradiol and receive supportive care in case of an overdose.
Prefest Novel Uses: Which Conditions Have a Clinical Trial Featuring Prefest?
At present, 867 active clinical trials are underway to ascertain the potential of Prefest to ameliorate Osteoporosis, Amenorrhea and Urogenital Atrophy.Condition
Clinical Trials
Trial Phases
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Polycystic Ovarian Syndrome
9 Actively Recruiting
Phase 1, Not Applicable, Phase 2, Phase 3, Early Phase 1, Phase 4
Hirsutism
0 Actively Recruiting
Postmenopausal Osteoporosis
3 Actively Recruiting
Not Applicable, Phase 4
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
moderate Vulvovaginal atrophy
0 Actively Recruiting
severe menopausal vulvovaginal atrophy
0 Actively Recruiting
Oral Contraceptives
2 Actively Recruiting
Not Applicable
Menopause
0 Actively Recruiting
Hypermenorrhea
0 Actively Recruiting
Menstrual Distress (Dysmenorrhea)
1 Actively Recruiting
Phase 4
Acne Vulgaris
0 Actively Recruiting
Prefest Reviews: What are patients saying about Prefest?
1Patient Review
11/4/2011 Within the past four months, something changed in the Prefest formulation and it caused a range of problems for me including pain in my legs, anxiety, insomnia, water retention, and bleeding. I had been taking this med for five years without any issues prior to this change.
Patient Q&A Section about prefest
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does estradiol cause breast cancer?
"This means that if you use estradiol for more than five years, you have a higher risk of developing breast cancer than someone who doesn't use this medication."
Answered by AI
How long does Femhrt take to work?
"Norethindrone acetate and ethinyl estradiol are quickly absorbed into the body from femhrt tablets, with maximum plasma concentrations of norethindrone and ethinyl estradiol typically occurring 1 to 2 hours after taking the medication."
Answered by AI
What is Prefest used for?
"Prefest is a combination of two medications: estradiol (an estrogen) and norgestimate (a progestin). Estradiol replaces the estrogen your body loses during menopause and relieves hot flashes, vaginal dryness, and strengthens bones. Norgestimate protects the uterus from damage and helps prevent uterine cancer."
Answered by AI