Climara Pro

Endometrial Hyperplasia, Endometriosis, Hot flashes + 6 more
Treatment
6 FDA approvals
20 Active Studies for Climara Pro

What is Climara Pro

LevonorgestrelThe Generic name of this drug
Treatment SummaryEstradiol is a hormone naturally found in females. It is available as a prescription medication to treat conditions caused by low estrogen levels, such as hot flashes and vulvovaginal atrophy. Estradiol can be taken orally, by injection, through a vaginal ring, patch, spray, gel, or cream. It is often combined with a pro-drug ester, such as ethinyl estradiol, to make it more effective when taken orally. Ethinyl estradiol is a synthetic form of estradiol that is commonly used in combination oral contraceptive pills.
Triphasil-21is the brand name
image of different drug pills on a surface
Climara Pro Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Triphasil-21
Levonorgestrel
1984
243

Approved as Treatment by the FDA

Levonorgestrel, also known as Triphasil-21, is approved by the FDA for 6 uses including moderate Menopausal Vasomotor Symptoms and Postmenopausal Osteoporosis .
moderate Menopausal Vasomotor Symptoms
Used to treat moderate Menopausal Vasomotor Symptoms in combination with Estradiol
Postmenopausal Osteoporosis
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
Menopause
Used to treat severe Vasomotor Symptoms Associated With Menopause in combination with Estradiol
Emergency Contraception
Has had at least 1 child
Hot flashes
Used to treat Menopause in combination with Estradiol

Effectiveness

How Climara Pro Affects PatientsEstradiol is used to treat symptoms related to menopause, such as hot flashes and vaginal dryness. It can also improve bone density by reducing bone resorption, and can raise levels of proteins like sex hormone binding globulin. Taking estradiol may also cause an increase in follicle-stimulating hormone. However, estradiol should be avoided by people at high risk of cardiovascular disease, deep vein thrombosis, or stroke, as it can cause a hyper-coagulable state. Additionally, taking estradiol may raise blood pressure due to an increase in angiotensin
How Climara Pro works in the bodyEstrogen is a hormone found in many parts of the body. In women, most of it is produced by the ovaries before menopause. After menopause, the majority of estrogen comes from the adrenal glands. Estrogen works by binding to two types of receptors, ERα and ERβ, and by stimulating the G Protein-coupled estrogen receptor. This causes the receptor to enter the nucleus of the target cell and regulate gene transcription. As a result, proteins are produced that have specific effects on the target cells. This leads to relief of common symptoms associated with low estrogen levels such as hot flashes, chills

When to interrupt dosage

The suggested dosage of Climara Pro is reliant upon the diagnosed disorder, such as Premature Menopause, Pharmaceutical Preparations and Postmenopause. The quantity of dosage varies, according to the method of delivery detailed in the table below.
Condition
Dosage
Administration
moderate Menopausal Vasomotor Symptoms
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Endometriosis
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Endometrial Hyperplasia
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Hot flashes
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Emergency Contraception
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Postmenopausal Osteoporosis
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Has had at least 1 child
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Hypermenorrhea
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Menopause
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral

Warnings

Climara Pro has eighteen contraindications, and should not be administered if you are suffering from any of the afflictions listed in the table below.Climara Pro Contraindications
Condition
Risk Level
Notes
Septic Abortion
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
infected abortions
Do Not Combine
HCG elevated
Do Not Combine
Pelvic Infection
Do Not Combine
Vaginitis
Do Not Combine
Acute Coryza
Do Not Combine
presence or history of breast cancer
Do Not Combine
Uterine Cervicitis
Do Not Combine
Communicable Diseases
Do Not Combine
gonococcal cervical infection
Do Not Combine
Breast Cancer
Do Not Combine
Intrauterine Devices
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
congenital or aquired uterine abnormality
Do Not Combine
Chlamydia Infections
Do Not Combine
Hypersensitivity
Do Not Combine
Emergency Contraception
Do Not Combine
Bacterial Endocarditis
Do Not Combine
lower genital tract infection
Do Not Combine
suspected pregnancy
Do Not Combine
Uterine Cervicitis
Do Not Combine
uterine neoplasia
Do Not Combine
Pelvic Inflammatory Disease
Do Not Combine
history of progestogen-sensitive breast cancer
Do Not Combine
Cervical Neoplasia
Do Not Combine
Fibroid Tumor
Do Not Combine
Postpartum Endometritis
Do Not Combine
chlamydial cervical infection
Do Not Combine
PAP Test Abnormalities
Do Not Combine
acute liver disease
Do Not Combine
Uterine anomaly distorting uterine cavity
Do Not Combine
Breast Cancer
Do Not Combine
Cervical Dysplasia
Do Not Combine
Thromboembolism
Do Not Combine
Bacterial Vaginosis
Do Not Combine
history of pelvic inflammatory disease
Do Not Combine
Breast
Do Not Combine
Vaginal Bleeding
Do Not Combine
Bacterial Vaginosis
Do Not Combine
Pelvic Inflammatory Disease
Do Not Combine
gonococcal cervical infection
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Levonorgestrel may interact with Pulse Frequency
There are 20 known major drug interactions with Climara Pro.
Common Climara Pro Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Levonorgestrel.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Levonorgestrel.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Levonorgestrel.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Levonorgestrel.
Crizotinib
Major
The metabolism of Crizotinib can be decreased when combined with Levonorgestrel.
Climara Pro Toxicity & Overdose RiskIn rats, the highest dose of estradiol without causing harm was 0.003mg/kg per day. The lowest toxic dose in women is 21mg/kg, and the highest toxic dose in rats is 960mg/kg. If someone has an overdose of estradiol, they may experience nausea, vomiting, abdominal pain, breast tenderness, blood clots, and vaginal bleeding. Treatment for estradiol overdose includes discontinuing the medication and providing supportive care.
image of a doctor in a lab doing drug, clinical research

Climara Pro Novel Uses: Which Conditions Have a Clinical Trial Featuring Climara Pro?

867 active trials are currently being conducted to assess the efficacy of Climara Pro in treating Osteoporosis, Secondary Amenorrhea and Urogenital Atrophy.
Condition
Clinical Trials
Trial Phases
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Endometriosis
31 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 2, Phase 4, Phase 1
Menopause
0 Actively Recruiting
Has had at least 1 child
0 Actively Recruiting
Emergency Contraception
1 Actively Recruiting
Phase 4
Endometrial Hyperplasia
9 Actively Recruiting
Phase 2, Not Applicable
Hypermenorrhea
0 Actively Recruiting
Postmenopausal Osteoporosis
2 Actively Recruiting
Not Applicable
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting

Climara Pro Reviews: What are patients saying about Climara Pro?

5Patient Review
8/18/2022
Climara Pro for "Change of Life" Signs
I find the patch very convenient to use. I change it once a week, on what I like to call "Menopause Monday." I haven't experienced any weight gain or loss since starting this treatment, but my brain fog, vaginal dryness, and sweats have all improved. I generally feel like my old self again with more energy.
5Patient Review
3/8/2022
Climara Pro for "Change of Life" Signs
I started seeing results within a week, and they just kept getting better and better. I did experience some light vaginal bleeding at the five-week mark, but my doctor says that's normal and nothing to worry about.
4.3Patient Review
12/7/2018
Climara Pro for "Change of Life" Signs
I had good results from this patch, but after a few months of use I started to experience some skin irritation. I'm hoping there's a milder solution out there that can give me the same peace and calm without the side effects.
4Patient Review
7/22/2018
Climara Pro for "Change of Life" Signs
This medication has been working great for me and has helped to lessen my bipolar II symptoms. I haven't experienced any negative side effects, which is amazing. Additionally, I found that keeping the patches away from heat seems to help with attachment problems.
3.7Patient Review
8/8/2019
Climara Pro for "Change of Life" Signs
I started using Climara Pro to mitigate my menopause symptoms, which it did to some extent. However, I have been experiencing vaginal bleeding for the past two months. My doctor says everything looks okay, but I really wish the bleeding would stop. Additionally, the patch could use more adhesive; it often falls off during hot summer months.
3Patient Review
5/28/2018
Climara Pro for Post-Menopausal Osteoporosis Prevention
It's really frustrating how hard it is to peel the backing off these patches. I've wasted so many because of it. That said, my bone density reports have been good since starting this medication, so I guess it's a love-hate relationship.
3Patient Review
4/22/2022
Climara Pro for "Change of Life" Signs
While this treatment was initially effective in managing my mood swings and hot flashes, I began to experience uncontrollable hunger which led to rapid weight gain. Consequently, I had to stop using the patch.
2.7Patient Review
5/23/2022
Climara Pro for "Change of Life" Signs
I found this product effective for menopause symptoms like hot flashes and body aches. However, I stopped using it after 8 months because I felt like it was making me forgetful. According to my research, early dementia is a side effect of this medication—and that's something I'd rather avoid in exchange for the hot flashes.
2.3Patient Review
3/1/2021
Climara Pro for "Change of Life" Signs
Out of the three boxes I received, only one had patches that actually worked. And even then, it killed my sex drive. So while it did help with hot flashes, I can't in good faith recommend this product.
1.7Patient Review
10/31/2022
Climara Pro for "Change of Life" Signs
The side effects of this medication were extremely unpleasant. I experienced hot, swollen hands and feet; headaches; weight gain; vaginal discharge; heart palpitations; breathlessness; itchy calves; total loss of libido; food cravings; blurred vision; and cramping. I was very glad to be done with the treatment after just four days.
1Patient Review
8/14/2019
Climara Pro for "Change of Life" Signs
The Climara Pro patch was a terrible experience for me. After just three days, the patch started coming off. By day four, it was almost completely gone and formed cone-shaped openings. I would not recommend this patch to anyone.
1Patient Review
6/1/2020
Climara Pro for "Change of Life" Signs
This patch is ridiculously expensive and it doesn't even stay on.
1Patient Review
3/27/2020
Climara Pro for "Change of Life" Signs
I found this patch to be ineffective as it did not stay on for the entire week. I would suggest that the manufacturers consider making a daily patch.
1Patient Review
10/17/2022
Climara Pro for "Change of Life" Signs
This patch is terrible. It's cheaply made, falls off constantly, and is a general waste of money. Do not bother buying this product.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about climara pro

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does it take for Climara Pro patch to work?

"I was prescribed Climara Pro and within four days, all my anxiety, hot flashes, and depression disappeared! It was like magic. Sometimes I have spotting or bleeding for a few days, but I'm happy to deal with that."

Answered by AI

What is Climara Pro used for?

"Climara Pro is a medication that contains both an estrogen and a progestogen. It is used to reduce hot flashes and help prevent osteoporosis in postmenopausal women who have a uterus."

Answered by AI

What are the side effects of Climara?

"You may experience skin redness or irritation, abdominal pain, nausea or vomiting, bloating, breast tenderness, headache, or weight changes when taking this medication. If you experience any of these symptoms, speak to your doctor or pharmacist."

Answered by AI

What is the difference between Climara and Climara Pro?

"Climara Pro and Climara are both skin patches. Climara Pro is applied once a week and Climara is applied once or twice a week."

Answered by AI

Clinical Trials for Climara Pro

Have you considered Climara Pro clinical trials? We made a collection of clinical trials featuring Climara Pro, we think they might fit your search criteria.
Have you considered Climara Pro clinical trials? We made a collection of clinical trials featuring Climara Pro, we think they might fit your search criteria.
Have you considered Climara Pro clinical trials? We made a collection of clinical trials featuring Climara Pro, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
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