What is Vagifem
EstradiolThe Generic name of this drug
Treatment SummaryEstradiol is a hormone naturally produced in females. It is used in hormone therapy to treat conditions related to low estrogen levels, such as hot flashes and vulvovaginal atrophy. It is available in many forms, including tablets, injections, vaginal rings, patches, sprays, gels, and creams. To increase its effectiveness when taken orally or through injection, estradiol is often combined with a pro-drug ester. Ethinyl estradiol is a synthetic form of estradiol that is more bioavailable and resistant to metabolism, making it the most common form used in combination oral contraceptive pills (
Estradermis the brand name
Vagifem Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Estraderm
Estradiol
1986
356
Approved as Treatment by the FDA
Estradiol, also known as Estraderm, is approved by the FDA for 4 uses like Palliative Treatment and Breast Cancer .Palliative Treatment
Breast Cancer
Birth Control
Used to treat Contraception in combination with Levonorgestrel
Hormonal Contraception
Used to treat Hormonal Contraception therapy in combination with Levonorgestrel
Effectiveness
How Vagifem Affects PatientsEstradiol is used to help relieve hot flashes, vaginal dryness, and pain during sex. It also helps increase bone density and can improve the levels of certain proteins in the liver. It can make blood clot more easily, which can increase the risk for heart disease, blood clots in veins, and stroke. Estradiol can also cause an increase in sodium retention and blood pressure.
How Vagifem works in the bodyEstrogen is a hormone found in many parts of the body, like the breast, skin, and brain. In women of reproductive age, the majority of estrogen is made by the ovaries. After menopause, the main source of estrogen is the adrenal glands, which produce androstenedione and then turn it into estrone in other tissues. Estrogen works by binding to two types of receptors, ERα and ERβ, and GPER which helps it take effect quickly. When the receptor binds to estrogen, it travels to the nucleus of the cell and triggers gene transcription. This creates proteins which cause the effects of estrogen
When to interrupt dosage
The measure of Vagifem is founded upon the identified ailment, including Premature Menopause, Pharmaceutical Preparations and Postmenopause. The measure of dosage fluctuates as per the approach of delivery delineated in the table beneath.Condition
Dosage
Administration
Therapeutic procedure
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
estradiol
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Birth Control
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Prostate Cancer
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
female castration
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Hypogonadism
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
moderate to severe symptoms
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Postmenopause
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Breast
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Palliation
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Low Testosterone
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Hot flashes
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Vasomotor Symptoms Associated With Menopause
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Hormonal Contraception
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Atrophic
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
hypoestrogenism
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Metastatic Breast Cancer
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Kraurosis Vulvae
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
advanced androgen dependent Prostate cancer
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
no menstrual period in previous 6 months
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Warnings
Vagifem has eighteen known contraindications and should be avoided for those experiencing the conditions given in the following table.Vagifem ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Estradiol may interact with Toxoplasma Infections
Deep Vein Thrombosis
Do Not Combine
Thromboembolism
Do Not Combine
Pulmonary Embolism
Do Not Combine
Thromboembolism
Do Not Combine
Neoplasms, Hormone-Dependent
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Liver Dysfunction
Do Not Combine
Thrombophilia
Do Not Combine
Breast
Do Not Combine
Breast
Do Not Combine
Angioedema
Do Not Combine
Breast Cancer
Do Not Combine
history of deep venous thrombosis
Do Not Combine
Pulmonary Embolism
Do Not Combine
Angioedema
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
suspected pregnancy
Do Not Combine
Common Vagifem Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Estradiol.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Estradiol.
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Estradiol.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Estradiol.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Estradiol.
Vagifem Toxicity & Overdose RiskStudies have found that taking estradiol for 90 days in rats had no adverse effects at doses of 0.003 mg/kg/day. The lowest toxic dose for ethinyl estradiol is 21 mg/kg/21D for women. An overdose of estradiol may cause nausea, vomiting, abdominal pain, breast tenderness, blood clots, and vaginal bleeding. If you suspect an overdose, it is recommended to stop taking the drug and get supportive care.
Vagifem Novel Uses: Which Conditions Have a Clinical Trial Featuring Vagifem?
867 ongoing studies are assessing the potential of Vagifem to alleviate Osteoporosis, absent menses for the preceding 6 months, and Urogenital Atrophy.Condition
Clinical Trials
Trial Phases
Hot flashes
19 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Osteoporosis
43 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3
Metastatic Breast Cancer
82 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Phase 4
Hormone Replacement Therapy
0 Actively Recruiting
Hypogonadism
0 Actively Recruiting
Birth Control
35 Actively Recruiting
Phase 4, Not Applicable, Phase 3, Phase 2, Early Phase 1
Vasomotor Symptoms Associated With Menopause
9 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Postmenopausal Osteoporosis
4 Actively Recruiting
Not Applicable, Phase 4, Phase 3
Low Testosterone
18 Actively Recruiting
Phase 1, Phase 2, Phase 4
Hormonal Contraception
0 Actively Recruiting
Hysterectomy
1 Actively Recruiting
Phase 4
Postmenopause
6 Actively Recruiting
Phase 2, Not Applicable, Phase 3
moderate to severe symptoms
0 Actively Recruiting
Atrophic
5 Actively Recruiting
Phase 4, Phase 2, Not Applicable, Early Phase 1
no menstrual period in previous 6 months
0 Actively Recruiting
Urogenital atrophy
0 Actively Recruiting
Kraurosis Vulvae
0 Actively Recruiting
Breast Cancer
718 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4
Premature Menopause
0 Actively Recruiting
Breast
0 Actively Recruiting
Vagifem Reviews: What are patients saying about Vagifem?
4.3Patient Review
5/16/2022 As someone who has gone through menopause, I've found this treatment to be very effective for my bladder problems and dry vagina. I haven't experienced any negative side effects, though there is the occasional thrush infection which may be caused by the applicator. Overall, this has worked well for me.
3.7Patient Review
5/11/2022 I've gained nine pounds, my breasts are larger and tender, my hair is falling out more quickly, I feel breathless and get mild headaches. While the moisturizing effect seems to have decreased, I do feel more comfortable deep inside and no longer feel like I have a UTI brewing all the time.
3Patient Review
8/9/2022 I initially had no issues with this medication, but after about a month I started to experience really unpleasant side effects like bloating, leg cramps, and hair loss. I'm hoping to speak to my doctor soon about discontinuing use.
3Patient Review
11/6/2022 I did not do my research on this medication before taking it, and I regret that now. I can't say for certain whether or not Vagifem is causing my problems, but it's certainly possible. I've been experiencing extreme bloating and pelvic pain which has made daily life very difficult. Additionally, I'm constantly feeling the need to urinate. The one side effect that concerns me most after reading these reviews is hair loss. I have already lost 50% of my hair, and the texture has changed for the worse. As of now, I will be stopping use of this medication."
2.7Patient Review
4/29/2022 I used this for five months to try and alleviate vaginal atrophy, but it only made the burning and stinging sensations worse. It also seemed to make my slight vaginal prolapse much worse. On top of all that, I got the worst thrush ever. So, on balance, I think I would have been better off without it.
2.7Patient Review
5/5/2022 I developed a really bad itch and discharge after using this for about eight days. It was like a yeast infection, so I stopped taking it immediately.
2.3Patient Review
4/20/2022 The new Vagirux applicator is too shallow and the tablet falls out constantly.
1Patient Review
3/14/2022 I've only been using this medication for four days, and I woke up this morning in excruciating pain. I'm continuing to take it as directed because I need a smear test, but the pain is unbearable. I don't know how I'm supposed to make it through 10 more days of this.
1Patient Review
10/11/2022 The burning was unbearable and I felt like I had to constantly go to the bathroom. The pressure in my bladder was really intense.
1Patient Review
2/25/2022 I have Ehlers-Danlos Syndrome and this medication made me very sick.
Patient Q&A Section about vagifem
What are the risks of taking Vagifem?
"Vagifem® users most often reported experiencing headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps, bloating, nausea and vomiting, hair loss, fluid retention, and vaginal yeast infection." - Anonymous Online Contributor
Unverified Answer
How quickly will Vagifem work?
"A study found that the drug Vagifem 10 mcg helped to reduce symptoms associated with vaginal atrophy in most women after 12 weeks of treatment, though some women reported seeing improvements as early as 8 weeks into treatment." - Anonymous Online Contributor
Unverified Answer
What does Vagifem do for a woman?
"This medication is used to help reduce vaginal symptoms of menopause in women. These symptoms are caused by the body making less estrogen and can include vaginal dryness, burning, and itching." - Anonymous Online Contributor
Unverified Answer
How long should you stay on Vagifem?
"It is currently recommended to continue using local estrogen therapy for as long as it is needed for symptom control. A study that looked back at data from over 13,000 women showed that, in the real world, local estrogen therapy is typically used for around 12 months." - Anonymous Online Contributor
Unverified Answer