Dairy Choline Bioavailability for Postmenopausal Health

Overseen By Kevin Shih

Age: 18+

Sex: Female

Trial Phase: Academic

Sponsor: University of Wisconsin, Madison

Must not be taking: Antibiotics, Probiotics, Laxatives, others

Disqualifiers: Fat malabsorption, Kidney diseases, Allergies, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 10 days

24 Participants Needed

Trial Summary

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you regularly use antibiotics, probiotics, prebiotics, Orlistat, Cetilistat, or laxatives, or if you are undergoing hormone replacement therapy.

How does the treatment Whole egg powder differ from other treatments for postmenopausal health?

Whole egg powder is unique because it provides choline in a natural form bound to phospholipids, which is absorbed more efficiently than synthetic choline supplements. This natural choline source may improve bone health and reduce inflammation without increasing cholesterol levels, offering additional benefits compared to standard choline supplements. ^{1 2 3 4 5}

What is the purpose of this trial?

The goal of this clinical trial is to find out if dairy is a good source of choline compared to eggs. The main questions it aims to answer are: * How the body uses choline; and, * What effect WPPC has on choline metabolism. Researchers will compare Whey Protein Phospholipid Concentrate (WPPC) to whole egg powder to see if WPPC is as effective as eggs. Participants will drink a chocolate-flavored drink mixed with either WPPC or whole egg powder.

Research Team

Bradley Bolling, PhD

Principal Investigator

University of Wisconsin, Madison

Eligibility Criteria

This trial is for postmenopausal individuals interested in understanding how their bodies use choline, a nutrient important for liver function, brain development, and muscle movement. Participants should be healthy with no major dietary restrictions that would prevent them from consuming dairy or eggs.

Inclusion Criteria

I do not have chronic kidney disease.

I am willing to drink chocolate-flavored study drinks.

I am between 51 and 70 years old.

Exclusion Criteria

On weight loss/weight gain diets

I have been diagnosed with chronic kidney disease.

I regularly use laxatives.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants consume a chocolate-flavored drink mixed with either WPPC or whole egg powder to assess choline bioavailability and metabolism

10 days

Follow-up

Participants are monitored for safety and effectiveness after treatment

2 weeks

Treatment Details

Interventions

• Whole egg powder
• WPPC

Trial Overview The study is testing the effectiveness of Whey Protein Phospholipid Concentrate (WPPC), a dairy product, against whole egg powder in providing choline to the body. Participants will consume a chocolate-flavored drink containing one of these ingredients to see which one improves choline metabolism better.

Participant Groups

Group I: Whey Protein Phospholipid Concentrate (WPPC) Experimental Treatment 1 Intervention

Participants will drink a chocolate-flavored drink with WPPC added

Group II: Pasteurized whole egg powder Experimental Treatment 1 Intervention

Participants will drink a chocolate-flavored drink with egg powder added

Who Is Running the Clinical Trial?

University of Wisconsin, Madison

Lead Sponsor

Trials

1,249

Recruited

3,255,000+

References

1. Switzerland pubmed.ncbi.nlm.nih.gov

Natural Choline from Egg Yolk Phospholipids Is More Efficiently Absorbed Compared with Choline Bitartrate; Outcomes of A Randomized Trial in Healthy Adults. [2020]

2. Switzerland pubmed.ncbi.nlm.nih.gov

Choline Intake as Supplement or as a Component of Eggs Increases Plasma Choline and Reduces Interleukin-6 without Modifying Plasma Cholesterol in Participants with Metabolic Syndrome. [2021]

3. England pubmed.ncbi.nlm.nih.gov

Utilization of choline from crude soybean lecithin by chicks. 2. Absorption measurements. [2023]

4. United States pubmed.ncbi.nlm.nih.gov

Egg n-3 fatty acid composition modulates biomarkers of choline metabolism in free-living lacto-ovo-vegetarian women of reproductive age. [2016]

5. United States pubmed.ncbi.nlm.nih.gov

Dietary Choline Intake Is Directly Associated with Bone Mineral Density in the Hordaland Health Study. [2017]