Memory Training for Mild Cognitive Impairment
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether memory retraining exercises can improve memory and daily functioning for individuals with Mild Cognitive Impairment (MCI), a condition affecting memory and thinking skills. Participants will join either a group performing memory retraining exercises or a placebo group engaging in similar activities without the retraining focus. This trial suits those over 60 who speak English and have been diagnosed with amnestic MCI, which specifically impacts memory. The researchers aim to determine if these exercises can significantly enhance everyday life and assess the longevity of the benefits. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research that could improve daily life for those with MCI.
Will I have to stop taking my current medications?
The trial excludes participants who use benzodiazepines and steroids, so you would need to stop taking these medications to participate.
What prior data suggests that this memory retraining technique is safe for individuals with Mild Cognitive Impairment?
Research has shown that memory retraining exercises are generally safe for people with Mild Cognitive Impairment (MCI). Studies have found that these exercises can enhance memory activity in the brain without major side effects. For example, one study reported that participants experienced improved overall thinking skills and felt more confident about their memory after the training, indicating that the exercises are well-tolerated. While most reports highlight the benefits, they do not mention any serious negative effects, which suggests good safety. However, it is important to consult a healthcare provider to understand any potential risks and benefits before joining a trial.12345
Why are researchers excited about this trial?
Researchers are excited about memory retraining exercises for mild cognitive impairment because these exercises offer a non-pharmacological approach to enhancing cognitive function. Unlike traditional treatments, which often involve medications like cholinesterase inhibitors, this method uses interactive exercises delivered via a laptop, making it accessible and easy to use. The focus on cognitive exercises could potentially improve memory and cognitive skills without the side effects commonly associated with drug therapies. This innovative approach might empower patients to actively participate in their treatment, potentially leading to improved daily functioning and quality of life.
What evidence suggests that memory retraining exercises could be effective for mild cognitive impairment?
Research has shown that memory exercises can significantly aid people with Mild Cognitive Impairment (MCI) in improving their memory. In this trial, participants in the experimental group will receive memory retraining exercises, which previous studies have shown to lead to better memory outcomes than health education alone. Another study found that these memory exercises can enhance specific behaviors and memory skills. Additionally, a review of several studies found that computer-based memory training benefits people with MCI or dementia. These findings suggest that memory exercises hold promise for helping people with MCI improve their memory and daily life. Meanwhile, participants in the placebo control group will receive placebo memory exercises for comparison.16789
Who Is on the Research Team?
Nancy D Chiaravalloti, PhD
Principal Investigator
Kessler Foundation
Are You a Good Fit for This Trial?
This trial is for individuals aged 60 or older who have been diagnosed with amnestic Mild Cognitive Impairment (MCI) and are fluent in English. It's not suitable for those with a history of stroke, neurological injuries/diseases, significant alcohol/drug abuse requiring inpatient treatment, use of benzodiazepines/steroids, or major psychiatric conditions like bipolar disorder or schizophrenia.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive memory retraining exercises or placebo memory exercises administered on a laptop computer twice a week for five weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment with assessments at multiple time points
Optional Neuroimaging
Optional enrollment in pre- and post-treatment neuroimaging to assess changes in the brain
What Are the Treatments Tested in This Trial?
Interventions
- Memory Retraining Exercises
- Placebo Control Memory Exercises
Find a Clinic Near You
Who Is Running the Clinical Trial?
Kessler Foundation
Lead Sponsor
Michigan State University
Collaborator
University of Michigan
Collaborator