Imaging Techniques for Brain Tumor
Trial Summary
What is the purpose of this trial?
This is a pilot study to assess a new methodology developed for High Grade Glioma (HGG). FMISO PET (Fluoromisonidazole-PET) allows researchers to study whether tumor cells lack oxygen (hypoxia). FLT PET (Fluorodeoxythymidine-PET) allows researchers to study the increase in the number of cells as a result of cell growth and cell division (proliferation). Tumors that have low oxygen levels and/or are dividing fast shall resist to standard cancer treatment. The study will compare FMISO PET and FLT PET imaging techniques with molecular biomarkers of hypoxia, angiogenesis, and cellular proliferation in tissue. proliferation).This information could help researchers develop new treatment techniques to better treat cancer.
Research Team
Sadek Nehmeh, PhD
Principal Investigator
Weill Medical College of Cornell University
Eligibility Criteria
This trial is for adults over 18 suspected to have High-Grade Glioma (HGG) based on clinical assessments and MRI results. It's not suitable for pregnant or breastfeeding individuals, or those who can't undergo PET scans due to conditions like claustrophobia.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Imaging
Simultaneous imaging of tumor hypoxia and proliferation using FMISO and FLT PET techniques
Surgical Planning and Sampling
Intraoperative neuro-navigation and targeted sampling of FMISO and FLT avid tumor subregions prior to tumor excision
Follow-up
Participants are monitored for safety and effectiveness after imaging and surgical procedures
Treatment Details
Interventions
- 18F-FLT PET
- 18F-FMISO PET
Find a Clinic Near You
Who Is Running the Clinical Trial?
Weill Medical College of Cornell University
Lead Sponsor
William Rhodes Center for Glioblastoma
Collaborator