← Back to Search

Polyphenol Nutraceutical

Muscadine Wine Polyphenols for Cognitive Functioning

N/A

Recruiting

Led By Liwei Gu, PhD

Research Sponsored by University of Florida

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, acute (4-hour post single dose), chronic (end of six week)

Awards & highlights

Study Summary

This trial will test if muscadine wine and juice can improve cognitive performance and mood by regulating the HPA axis, alleviating inflammation and oxidative stress, and/or inhibiting monoamine oxidase activities.

Who is the study for?

This trial is for healthy adults with a BMI of 18.5-29.9 and body weight over 110 pounds, who drink occasionally to moderately. It's not for smokers, heavy drinkers, pregnant or breastfeeding individuals, those with mental illnesses, cardiovascular or neurological disorders, diabetes, or on certain medications.Check my eligibility

What is being tested?

The study tests if muscadine wine polyphenols can improve brain health and mood compared to a placebo. Participants will consume these compounds regularly to see if they affect cognitive performance by reducing stress responses and inflammation.See study design

What are the potential side effects?

While the trial doesn't list specific side effects of muscadine wine polyphenols, similar substances sometimes cause digestive upset or allergic reactions in sensitive individuals.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, acute (4-hour post single dose), chronic (end of six week)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, acute (4-hour post single dose), chronic (end of six week)

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, acute (4-hour post single dose), chronic (end of six week) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change from baseline brain-derived neurotrophic factors

Change from baseline cognitive performance score after intervention/placebo

Change from baseline cognitive performance score after intervention/placebo - continued

+3 more

Secondary outcome measures

Change from baseline depression score after intervention/placebo

Change from baseline mood and anxiety score after intervention/placebo

Change from baseline pro-inflammatory cytokines

Trial Design

2Treatment groups

Active Control

Group I: Intervention-PlaceboActive Control2 Interventions

Participants in this arm will consume muscadine wine polyphenol for six weeks and then placebo for another six weeks. The two phases are separated by a 21-day washout period

Group II: Placebo-InterventionActive Control2 Interventions

Participants in this arm will first consume placebo for six weeks and then muscadine wine polyphenol for another six weeks. The two phases are separated by a 21-day washout period

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of FloridaLead Sponsor

1,340 Previous Clinical Trials

715,680 Total Patients Enrolled

1 Trials studying Memory

32 Patients Enrolled for Memory

Liwei Gu, PhDPrincipal InvestigatorUniversity of Florida

6 Previous Clinical Trials

315 Total Patients Enrolled

Media Library

Muscadine Wine Nutraceuticals (Polyphenol Nutraceutical) Clinical Trial Eligibility Overview. Trial Name: NCT05541887 — N/A

Memory Research Study Groups: Intervention-Placebo, Placebo-Intervention

Memory Clinical Trial 2023: Muscadine Wine Nutraceuticals Highlights & Side Effects. Trial Name: NCT05541887 — N/A

Muscadine Wine Nutraceuticals (Polyphenol Nutraceutical) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05541887 — N/A

Memory Patient Testimony for trial: Trial Name: NCT05541887 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the age requirement for this clinical trial including those of 45 and above?

"This trial is geared towards individuals aged 50 to 65. For those younger than the specified age, there are 148 trials available; for those over the cut-off, 458 opportunities exist."

Answered by AI

Are there any available positions for participants in this experiment?

"Clinicaltrials.gov reports that this trial, which was initially posted on December 1st 2022 and subsequently updated in September of the same year, is not presently seeking applicants. Yet, there are 655 other trials looking for participants at this exact moment."

Answered by AI

Is participation in this experiment open to the public?

"This experimental research requires 28 participants aged 50 to 65 who suffer from memory loss. Furthermore, they must have a Body Mass Index between 18.5-29.9 and weigh more than 110 pounds; in addition, healthiness is imperative as occasional or moderate drinking habits (2-5 drinks per week for women and 2-8 weekly for men)."

Answered by AI