Levophed

Hypovolemic Shock, Sudden Cardiac Arrest, Hypotension + 1 more
Treatment
13 Active Studies for Levophed

What is Levophed

NorepinephrineThe Generic name of this drug
Treatment SummaryNorepinephrine is a hormone and neurotransmitter produced by the adrenal gland. It helps to regulate the body’s fight-or-flight response and is involved in the transmission of signals from the brain to parts of the body. It can also be found in plants and is used in medications to stimulate the sympathetic nervous system.
Levophedis the brand name
image of different drug pills on a surface
Levophed Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Levophed
Norepinephrine
1982
31

Effectiveness

How Levophed Affects PatientsNoradrenaline affects the two types of adrenergic receptors (alpha-1 and alpha-2), causing the blood vessels to constrict. When tested in the lab, noradrenaline causes an increase in blood pressure because it blocks the action of the receptors, which increases the amount of resistance in the blood vessels.
How Levophed works in the bodyNorepinephrine constricts blood vessels in the body, and also helps the heart beat stronger and increases the size of the arteries supplying it with blood. These effects are due to its activity on different types of adrenergic receptors.

When to interrupt dosage

The measure of Levophed is contingent upon the specified condition, such as Hypotension, Hypovolemic Shock and Hypotension. The extent of dosage is contingent upon the technique of delivery (e.g. Intravenous or Injection, solution) featured in the table beneath.
Condition
Dosage
Administration
Hypotension
, 1.0 mg/mL, 0.016 mg/mL, 0.064 mg/mL, 0.032 mg/mL, 0.04 mg/mL, 0.08 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Hypovolemic Shock
, 1.0 mg/mL, 0.016 mg/mL, 0.064 mg/mL, 0.032 mg/mL, 0.04 mg/mL, 0.08 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Sudden Cardiac Arrest
, 1.0 mg/mL, 0.016 mg/mL, 0.064 mg/mL, 0.032 mg/mL, 0.04 mg/mL, 0.08 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Hypotension
, 1.0 mg/mL, 0.016 mg/mL, 0.064 mg/mL, 0.032 mg/mL, 0.04 mg/mL, 0.08 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous

Warnings

Levophed has six contraindications and must not be implemented when experiencing any of the conditions in the following table.Levophed Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Hypoxia
Do Not Combine
mesenteric or peripheral vascular thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
Hypotension
Do Not Combine
Hypercarbia
Do Not Combine
There are 20 known major drug interactions with Levophed.
Common Levophed Drug Interactions
Drug Name
Risk Level
Description
2,5-Dimethoxy-4-ethylamphetamine
Major
The therapeutic efficacy of 2,5-Dimethoxy-4-ethylamphetamine can be increased when used in combination with Norepinephrine.
2,5-Dimethoxy-4-ethylthioamphetamine
Major
The therapeutic efficacy of 2,5-Dimethoxy-4-ethylthioamphetamine can be increased when used in combination with Norepinephrine.
4-Bromo-2,5-dimethoxyamphetamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyamphetamine can be increased when used in combination with Norepinephrine.
Acebutolol
Major
The therapeutic efficacy of Acebutolol can be increased when used in combination with Norepinephrine.
Amphetamine/Dextroamphetamine
Major
The therapeutic efficacy of Amphetamine can be increased when used in combination with Norepinephrine.
Levophed Toxicity & Overdose RiskTaking large amounts of vasopressin, or taking it in combination with other medications, can cause poor circulation in the limbs and may even lead to tissue death.

Levophed Novel Uses: Which Conditions Have a Clinical Trial Featuring Levophed?

34 active studies are investigating the potential of Levophed in treating Heart attack, Hypotension and Hypovolemic Shock.
Condition
Clinical Trials
Trial Phases
Hypovolemic Shock
8 Actively Recruiting
Phase 4, Phase 3, Not Applicable, Phase 2
Hypotension
0 Actively Recruiting
Sudden Cardiac Arrest
5 Actively Recruiting
Not Applicable
Hypotension
0 Actively Recruiting

Levophed Reviews: What are patients saying about Levophed?

5Patient Review
10/16/2008
Levophed for Severely Low Blood Pressure
3Patient Review
8/24/2010
Levophed for Severely Low Blood Pressure
2Patient Review
11/30/2010
Levophed for Sudden Drop in Blood Pressure
When I was septic due to drinking urine, this helped my blood pressure. However, I would not recommend it because it tastes terrible.
1Patient Review
7/10/2013
Levophed for Severely Low Blood Pressure
My father was given this treatment in the hospital and we were told he could only have it for a few days. When they stopped his drip, he died.
1Patient Review
2/5/2018
Levophed for Severely Low Blood Pressure
I had a terrible experience with this treatment. I was already in the hospital for DKA and then the trauma team started levophed through my IV. It caused me a lot of pain.

Patient Q&A Section about levophed

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How quickly does Levophed work?

"After norepinephrine is administered intravenously, it quickly enters into a steady state. Its effects then wear off within 1-2 minutes after the infusion is stopped."

Answered by AI

What is the drug Levophed used for?

"Levophed works by constricting blood vessels and increasing blood pressure. This results in more blood flowing to the body's vital organs. Levophed is typically only given when other methods, such as IV fluids, have failed to increase blood pressure."

Answered by AI

Is Levophed a vasopressor?

"Vasopressors may be necessary for septic shock that does not improve after fluid resuscitation. Some commonly used vasopressors for septic shock include norepinephrine (Levophed), epinephrine, vasopressin, phenylephrine (Neo-Synephrine), and dopamine."

Answered by AI

How does Levophed work in the body?

"The LEVOPHED solution has a pH of 3 to 4.5 and is displacing the air in the vials with nitrogen gas. LEVOPHED has an alpha-adrenergic action that functions as a peripheral vasoconstrictor, and it also has a beta-adrenergic action that functions as an inotropic stimulator of the heart and dilator of the coronary arteries."

Answered by AI

Clinical Trials for Levophed

Image of Rush University Medical Center in Chicago, United States.

Precision-Controlled Ventilation for Cardiac Arrest

18+
All Sexes
Chicago, IL
Cardiac arrest is a life-threatening emergency that requires immediate treatment with cardiopulmonary resuscitation (CPR). While chest compressions circulate blood, manual ventilation provides oxygen to the patient. Current CPR guidelines recommend specific ventilation rates and tidal volumes, but studies show that clinicians often deliver too much or too little ventilation due to a lack of monitoring tools, potentially reducing the effectiveness of CPR and impacting survival. The PRECISION-CPR study is a multi-center, randomized controlled trial designed to evaluate whether using real-time feedback devices to precisely control ventilation during CPR can improve patient outcomes. Adult patients experiencing in-hospital cardiac arrest will be randomized to receive either standard manual ventilation guided by clinician experience or precision-controlled ventilation tailored to the patient's predicted body weight using real-time monitoring devices. The primary outcome of the study will be return of spontaneous circulation (ROSC). Secondary outcomes will include survival to hospital discharge, neurological recovery, and other clinical measures. By addressing the limitations of current ventilation practices, this study aims to generate evidence to guide future resuscitation guidelines and improve survival rates after cardiac arrest.
Waitlist Available
Has No Placebo
Rush University Medical Center
Image of University of Pittsburgh Department of Emergency Medicine in Pittsburgh, United States.

Specialty Care for Cardiac Arrest

18+
All Sexes
Pittsburgh, PA
This randomized clinical trial will determine if adult participants who are in the emergency department after being resuscitated from a cardiac arrest outside of the hospital benefit from care delivered at specialized centers. The main question that it will answer is whether transferring participants to a hospital with a specialized cardiac arrest service improves recovery of function after 90 days. Participants will receive all usual medical care, but some participants will be offered transfer to a regional cardiac arrest center and others will be offered care at the closest appropriate hospital. Investigators will interview participants after 90 days to assess their recovery.
Waitlist Available
Has No Placebo
University of Pittsburgh Department of Emergency MedicineJonathan Elmer, MD, MS
Have you considered Levophed clinical trials? We made a collection of clinical trials featuring Levophed, we think they might fit your search criteria.Go to Trials
Image of Vanderbilt University Medical Center in Nashville, United States.

Augmented Pacing for Bradycardia

18+
All Sexes
Nashville, TN
The goal of this clinical trial is to learn if backup pacing at an increased rate improves hemodynamics in adults with relative bradycardia, a permanent pacemaker, and cardiogenic shock. The main question it aims to answer is: Does increasing the backup pacing rate to 100 beats per minute lead to improved cardiac index compared to a backup pacing rate of 75 beats per minute Participants who are already hospitalized in the Cardiovascular Intensive Care Unit with a permanent pacemaker and pulmonary artery catheter in place will be enrolled in this study. Participants will be exposed to each pacemaker rate in a randomized order with hemodynamics assessed after 10 minutes at each rate.
Recruiting
Has No Placebo
Vanderbilt University Medical Center
Image of London Health Sciences Center in London, Canada.

Ultrasound-Guided Management for Septic Shock

18+
All Sexes
London, Canada
The goal of this pilot clinical trial is to determine if conducting a larger study using venous excess ultrasound (VEXUS) to guide fluid management in patients with septic shock is feasible. Septic shock is a life-threatening condition where infection causes dangerously low blood pressure. While fluids are essential for treatment, too much fluid can harm the kidneys and result in the need for dialysis. The main questions it aims to answer are: 1. Is it feasible to recruit patients, obtain consent, and follow the VEXUS-guided management protocol? 2. Does VEXUS-guided management, compared with usual care, improve the health and well-being of patients with septic shock? Researchers will compare two groups: one receiving VEXUS-guided fluid management versus another receiving standard care, to assess the feasibility of a larger trial and explore whether VEXUS prevents fluid overload and kidney problems. Participants in the VEXUS group will: 1. Undergo VEXUS scans every 24 hours for 3 days 2. Receive fluid management guided by VEXUS findings (including fluid restriction or removal if we identify venous congestion) and undergo cardiac ultrasound if we identify moderate to severe congestion 3. Be monitored for 28 days to track kidney function, need for dialysis, and survival.
Phase 3
Waitlist Available
London Health Sciences Center
Image of The Ottawa Hospital (General Campus) in Ottawa, Canada.

Stem Cell Therapy for Septic Shock

18+
All Sexes
Ottawa, Canada
Septic shock is associated with substantial burden in terms of both mortality and morbidity for survivors of this illness. Pre-clinical sepsis studies suggest that mesenchymal stem (stromal) cells (MSCs) modulate inflammation, enhance pathogen clearance and tissue repair and reduce death. Our team has completed a Phase I dose escalation and safety clinical trial that evaluated MSCs in patients with septic shock. The Cellular Immunotherapy for Septic Shock Phase I (CISS) trial established that MSCs appear safe and that a randomized controlled trial (RCT) is feasible. Based on these data, the investigators have planned a phase II RCT (UC-CISS II) at several Canadian academic centres which will evaluate intermediate measures of clinical efficacy (primary outcome), as well as biomarkers, safety, clinical outcome measures, and a health economic analysis (secondary outcomes).
Phase 2
Recruiting
The Ottawa Hospital (General Campus) (+1 Sites)Lauralyn McIntyre, MD
Have you considered Levophed clinical trials? We made a collection of clinical trials featuring Levophed, we think they might fit your search criteria.Go to Trials
Image of Brigham & Women's Hospital in Boston, United States.

Health Information Exchange Platform for Improving Patient Transfers

18+
All Sexes
Boston, MA
Sub-optimal transfer of clinical information during inter-hospital transfer (IHT, the transfer of patients between acute care hospitals) is common and can lead to patient harm. To address this problem, the investigators will use key stakeholder input to refine and implement an interoperable health information exchange platform that integrates with the electronic health record and improves the reliability of and access to necessary clinical information in three use cases involving transfer of patients between sending and receiving hospitals with varying levels of affiliation and health record integration. The investigators will assess the effect of this intervention on frequency of medical errors, evaluate the use and usability of this platform from the perspective of those that interact with it, and use these results to develop a dissemination plan to spread implementation and use of this platform across other similar institutions.
Waitlist Available
Has No Placebo
Brigham & Women's Hospital
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