Precision-Controlled Ventilation for Cardiac Arrest

Not yet recruiting at 1 trial location

Overseen By Brady Scott, PhD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Rush University Medical Center

Disqualifiers: ECMO, Pregnancy, Extreme body habitus, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: Up to 60 minutes

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests whether real-time feedback devices during CPR can improve outcomes for people experiencing cardiac arrest (when the heart suddenly stops beating). The study compares two groups: one receiving standard ventilation based on clinician judgment and another using devices to control breathing according to body weight, known as Precision-Controlled Ventilation. The researchers aim to determine if this new method helps restart the heart and improves survival rates. The trial involves adults who experience cardiac arrest in the hospital. As an unphased trial, participants contribute to innovative research that could enhance CPR techniques and improve survival outcomes for future patients.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that precision-controlled ventilation is safe for cardiac arrest patients?

Research has shown that real-time feedback devices during CPR help control breathing more accurately, ensuring the right amount of air reaches the lungs at the correct speed. Studies have found that healthcare providers using this feedback are more likely to follow breathing guidelines, leading to better patient outcomes.

These real-time feedback devices have been used safely in other situations and are generally well-tolerated. No specific evidence indicates harmful effects from their use during CPR. Although the trial is not in a specific phase, this suggests that the devices' safety is well-understood. The goal is to improve CPR without adding risk to the patient.

This method aims to increase survival rates and recovery after cardiac arrest by ensuring optimal breathing support, which is crucial for patient safety and outcomes. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about Precision-Controlled Ventilation for cardiac arrest because it introduces real-time feedback in manual ventilation during CPR. Unlike the standard practice where clinicians estimate ventilation based on chest rise, this method uses devices like EOlife to guide precise tidal volume and ventilation rate. This precision aims to adhere closely to guideline-recommended parameters, potentially improving patient outcomes by ensuring optimal ventilation during critical moments.

What evidence suggests that precision-controlled ventilation is effective for cardiac arrest?

This trial will compare Precision-Controlled Ventilation with Real-Time Feedback to Standard of Care Ventilation during CPR. Research has shown that real-time feedback devices during CPR can enhance the quality of breathing support. One study found that these devices helped achieve the recommended targets for breath volume and rate more frequently. Inadequate breathing support often occurs during CPR, happening in over 60% of pauses in some cases. By ensuring correct breathing, this precise method may improve the chances of restarting the heart. This approach aims to increase survival rates after cardiac arrest by making CPR more effective. ^{1 6 7 8 9}

Are You a Good Fit for This Trial?

The PRECISION-CPR trial is for adult patients who experience a cardiac arrest while in the hospital. To participate, they must be eligible to receive CPR as per current guidelines. The study excludes individuals with conditions that may interfere with precise ventilation control or those who have do-not-resuscitate (DNR) orders.

Inclusion Criteria

I am 18 or older and received CPR with manual breathing support in the hospital.

Exclusion Criteria

Inability to estimate predicted body weight (e.g., extreme body habitus or lack of height data)

Patients receiving Extracorporeal Membrane Oxygenation (ECMO)

Known pregnancy

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

Immediate

Treatment

Participants receive manual ventilation during CPR with or without real-time feedback devices

Up to 60 minutes

During cardiac arrest event

Follow-up

Participants are monitored for outcomes such as ROSC, survival to hospital discharge, and neurological recovery

Up to 28 days

Regular monitoring during hospital stay

Extended Follow-up

Monitoring of secondary outcomes such as duration of mechanical ventilation and length of ICU stay

Up to 60 days

What Are the Treatments Tested in This Trial?

Interventions

• Precision-Controlled Ventilation

Trial Overview This study compares standard manual ventilation during CPR against precision-controlled ventilation using real-time feedback devices. It aims to determine if more accurate control of breathing support improves outcomes like return of spontaneous circulation and survival rates.

How Is the Trial Designed?

Group I: Precision-Controlled Ventilation with Real-Time Feedback Experimental Treatment 1 Intervention

Patients will receive manual ventilation during CPR using real-time feedback devices (EOlife) to guide tidal volume (6-8 mL/kg predicted body weight) and ventilation rate (10 breaths per minute) delivery, ensuring adherence to guideline-recommended ventilation parameters.

Group II: Standard of Care Ventilation During CPR Active Control 1 Intervention

Patients will receive manual ventilation during CPR per standard practice without real-time feedback, using clinician judgment for tidal volume (visible chest rise) and ventilation rate, consistent with American Heart Association guidelines.

Who Is Running the Clinical Trial?

Rush University Medical Center

Lead Sponsor

Trials

448

Recruited

247,000+

Citations

1. clinicaltrials.gov clinicaltrials.gov/study/NCT07088120

PRecision-Controlled Ventilation in CPR Secondary outcomes will include survival to hospital discharge, neurological recovery, and other clinical measures. By addressing the limitations of current ...

2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC12441615/

Real-time ventilation quality feedback devices efficacy in out ... Recently, inadequate ventilation delivery was observed in more than 60 % of pauses during 30:2 CPR in adult out-of hospital cardiac arrest (OHCA) ...

3. sciencedirect.com sciencedirect.com/science/article/pii/S0300957224002752

The impact of real-time feedback on ventilation quality ... The use of real-time feedback was associated with an increased proportion of ventilations that were compliant with pre-defined targets during cardiac ...

4. withpower.com withpower.com/trial/phase-respiratory-aspiration-8-2025-e0a3e

Precision-Controlled Ventilation for Cardiac Arrest Secondary outcomes will include survival to hospital discharge, neurological recovery, and other clinical measures. By addressing the limitations of current ...

5. sjtrem.biomedcentral.com sjtrem.biomedcentral.com/articles/10.1186/s13049-025-01456-6

The effectiveness and perceived value of feedback used in ... This review evaluated the effectiveness and perceived value of feedback methods in cardiac arrest simulation-based education for healthcare, ...

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC7493547/

A review of ventilation in adult out‐of‐hospital cardiac arrest Patients managed initially with the King LT showed higher survival at 72 hours compared to those initially managed with endotracheal intubation. Rates of return ...

7. ahajournals.org ahajournals.org/doi/10.1161/CIR.0000000000001369

Part 7: Adult Basic Life Support: 2025 ... CARES OHCA data from 2024 showed that survival to hospital discharge was 10.5%, with favorable neurological outcome reported in approximately ...

8. sciencedirect.com sciencedirect.com/science/article/pii/S0300957224002600

Review Ventilation during cardiopulmonary resuscitation This narrative review aims to provide an overview of various components and challenges of ventilation during cardiopulmonary resuscitation.

9. resuscitationjournal.com resuscitationjournal.com/article/S0300-9572(25)00276-X/fulltext

Influence of different ventilation strategies during ... CCSV showed no survival advantage despite increased hospital transport with ongoing CPR. •. Mechanical ventilation was associated with better ...