Precision-Controlled Ventilation for Cardiac Arrest
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether real-time feedback devices during CPR can improve outcomes for people experiencing cardiac arrest (when the heart suddenly stops beating). The study compares two groups: one receiving standard ventilation based on clinician judgment and another using devices to control breathing according to body weight, known as Precision-Controlled Ventilation. The researchers aim to determine if this new method helps restart the heart and improves survival rates. The trial involves adults who experience cardiac arrest in the hospital. As an unphased trial, participants contribute to innovative research that could enhance CPR techniques and improve survival outcomes for future patients.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that precision-controlled ventilation is safe for cardiac arrest patients?
Research has shown that real-time feedback devices during CPR help control breathing more accurately, ensuring the right amount of air reaches the lungs at the correct speed. Studies have found that healthcare providers using this feedback are more likely to follow breathing guidelines, leading to better patient outcomes.
These real-time feedback devices have been used safely in other situations and are generally well-tolerated. No specific evidence indicates harmful effects from their use during CPR. Although the trial is not in a specific phase, this suggests that the devices' safety is well-understood. The goal is to improve CPR without adding risk to the patient.
This method aims to increase survival rates and recovery after cardiac arrest by ensuring optimal breathing support, which is crucial for patient safety and outcomes.12345Why are researchers excited about this trial?
Researchers are excited about Precision-Controlled Ventilation for cardiac arrest because it introduces real-time feedback in manual ventilation during CPR. Unlike the standard practice where clinicians estimate ventilation based on chest rise, this method uses devices like EOlife to guide precise tidal volume and ventilation rate. This precision aims to adhere closely to guideline-recommended parameters, potentially improving patient outcomes by ensuring optimal ventilation during critical moments.
What evidence suggests that precision-controlled ventilation is effective for cardiac arrest?
This trial will compare Precision-Controlled Ventilation with Real-Time Feedback to Standard of Care Ventilation during CPR. Research has shown that real-time feedback devices during CPR can enhance the quality of breathing support. One study found that these devices helped achieve the recommended targets for breath volume and rate more frequently. Inadequate breathing support often occurs during CPR, happening in over 60% of pauses in some cases. By ensuring correct breathing, this precise method may improve the chances of restarting the heart. This approach aims to increase survival rates after cardiac arrest by making CPR more effective.16789
Are You a Good Fit for This Trial?
The PRECISION-CPR trial is for adult patients who experience a cardiac arrest while in the hospital. To participate, they must be eligible to receive CPR as per current guidelines. The study excludes individuals with conditions that may interfere with precise ventilation control or those who have do-not-resuscitate (DNR) orders.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive manual ventilation during CPR with or without real-time feedback devices
Follow-up
Participants are monitored for outcomes such as ROSC, survival to hospital discharge, and neurological recovery
Extended Follow-up
Monitoring of secondary outcomes such as duration of mechanical ventilation and length of ICU stay
What Are the Treatments Tested in This Trial?
Interventions
- Precision-Controlled Ventilation
Trial Overview
This study compares standard manual ventilation during CPR against precision-controlled ventilation using real-time feedback devices. It aims to determine if more accurate control of breathing support improves outcomes like return of spontaneous circulation and survival rates.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Patients will receive manual ventilation during CPR using real-time feedback devices (EOlife) to guide tidal volume (6-8 mL/kg predicted body weight) and ventilation rate (10 breaths per minute) delivery, ensuring adherence to guideline-recommended ventilation parameters.
Patients will receive manual ventilation during CPR per standard practice without real-time feedback, using clinician judgment for tidal volume (visible chest rise) and ventilation rate, consistent with American Heart Association guidelines.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Rush University Medical Center
Lead Sponsor
Citations
PRecision-Controlled Ventilation in CPR
Secondary outcomes will include survival to hospital discharge, neurological recovery, and other clinical measures. By addressing the limitations of current ...
Real-time ventilation quality feedback devices efficacy in out ...
Recently, inadequate ventilation delivery was observed in more than 60 % of pauses during 30:2 CPR in adult out-of hospital cardiac arrest (OHCA) ...
The impact of real-time feedback on ventilation quality ...
The use of real-time feedback was associated with an increased proportion of ventilations that were compliant with pre-defined targets during cardiac ...
Precision-Controlled Ventilation for Cardiac Arrest
Secondary outcomes will include survival to hospital discharge, neurological recovery, and other clinical measures. By addressing the limitations of current ...
The effectiveness and perceived value of feedback used in ...
This review evaluated the effectiveness and perceived value of feedback methods in cardiac arrest simulation-based education for healthcare, ...
A review of ventilation in adult out‐of‐hospital cardiac arrest
Patients managed initially with the King LT showed higher survival at 72 hours compared to those initially managed with endotracheal intubation. Rates of return ...
Part 7: Adult Basic Life Support: 2025 ...
CARES OHCA data from 2024 showed that survival to hospital discharge was 10.5%, with favorable neurological outcome reported in approximately ...
Review Ventilation during cardiopulmonary resuscitation
This narrative review aims to provide an overview of various components and challenges of ventilation during cardiopulmonary resuscitation.
Influence of different ventilation strategies during ...
CCSV showed no survival advantage despite increased hospital transport with ongoing CPR. •. Mechanical ventilation was associated with better ...
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.