Capoten

Ventricular Dysfunction, Left, Hyperaldosteronism, Renal Artery Stenosis + 9 more
Treatment
10 FDA approvals
20 Active Studies for Capoten

What is Capoten

CaptoprilThe Generic name of this drug
Treatment SummaryCaptopril is a medication used to lower blood pressure. It works by blocking the enzyme angiotensin-converting enzyme (ACE) which is responsible for converting angiotensin I to angiotensin II. Angiotensin II is part of the renin-angiotensin-aldosterone system (RAAS) and helps to regulate blood pressure. Captopril can be used to treat high blood pressure.
Capotenis the brand name
image of different drug pills on a surface
Capoten Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Capoten
Captopril
1981
183

Approved as Treatment by the FDA

Captopril, otherwise known as Capoten, is approved by the FDA for 10 uses like Ventricular Dysfunction, Left and Hypertensive disease .
Ventricular Dysfunction, Left
Helps manage ejection fraction of 40% or less Left ventricular dysfunction
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Hydrochlorothiazide
ejection fraction of 40% or less Left ventricular dysfunction
Helps manage ejection fraction of 40% or less Left ventricular dysfunction
Congestive Heart Failure (CHF)
Helps manage Congestive Heart Failure (CHF)
Diabetic Nephropathy
Helps manage Diabetic Nephropathy
Type 1 Diabetes Mellitus
Helps manage Type 1 Diabetes Mellitus
Type 1 Diabetes
Helps manage Type 1 Diabetes Mellitus
Heart Attack
Helps manage Myocardial Infarction
Congestive Heart Failure
Helps manage Congestive Heart Failure (CHF)
Diabetic Nephropathies
Helps manage Diabetic Nephropathy

Effectiveness

How Capoten Affects PatientsCaptopril, an ACE inhibitor, works by blocking the effect of the RAAS, which is a system used by the body to control blood pressure and other things. When the body senses that blood pressure is too low, it releases a hormone called renin which turns into a substance called angiotensin II (ATII). ATII makes the body hold onto more water and salt, which can increase blood pressure. It also causes blood vessels to narrow, further increasing blood pressure. Captopril stops the body from making ATII, which helps lower blood pressure. It also stops the body from breaking down bradykinin,
How Capoten works in the bodyACE inhibitors are drugs that reduce blood pressure. They work by blocking the action of an enzyme called angiotensin-converting enzyme (ACE). There are two kinds of ACE, one found in the body and one found in the testes. ACE inhibitors block both types of ACE, but are more effective at blocking the kind found in the body. Captopril is an ACE inhibitor that binds to ACE and stops it from breaking down another protein called angiotensin I. When ACE is blocked, blood pressure is lowered. Captopril also increases the amount of a hormone called renin, which helps the body release more water

When to interrupt dosage

The advised measure of Capoten is contingent upon the recognized disorder, including Heart Attack, Non-STEMI Acute Coronary Syndrome and Aldosteronism. The measure of dosage is variable, according to the technique of delivery (e.g. Oral or Tablet - Oral) laid out in the table beneath.
Condition
Dosage
Administration
Ventricular Dysfunction, Left
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Hypertension
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Hyperaldosteronism
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Renal Artery Stenosis
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Heart Attack
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Diabetic Nephropathies
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Hypertensive disease
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Congestive Heart Failure
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Type 1 Diabetes
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Congestive Heart Failure
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Raynaud Disease
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Myocardial Infarction
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral

Warnings

There are 20 known major drug interactions with Capoten.
Common Capoten Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Captopril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Captopril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Captopril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Captopril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Captopril.
Capoten Toxicity & Overdose RiskTaking too much of this drug may result in vomiting and low blood pressure. Other possible side effects include a rash, changes in taste, coughing, stomach upset, and swelling of the face and tongue.
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Capoten Novel Uses: Which Conditions Have a Clinical Trial Featuring Capoten?

554 active trials are currently being conducted to assess the potential of Capoten to treat Type 1 Diabetes, Myocardial Infarction and Hypertensive Crisis.
Condition
Clinical Trials
Trial Phases
Type 1 Diabetes
192 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4
Congestive Heart Failure
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Hypertensive disease
28 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Congestive Heart Failure
186 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Diabetic Nephropathies
0 Actively Recruiting
Ventricular Dysfunction, Left
0 Actively Recruiting
Myocardial Infarction
0 Actively Recruiting
Heart Attack
23 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Early Phase 1, Phase 3
Renal Artery Stenosis
0 Actively Recruiting
Hyperaldosteronism
0 Actively Recruiting
Raynaud Disease
1 Actively Recruiting
Phase 4
Hypertension
0 Actively Recruiting

Capoten Reviews: What are patients saying about Capoten?

4Patient Review
1/24/2008
Capoten for High Blood Pressure
My blood pressure was significantly lower after taking this medication.
2.3Patient Review
11/12/2007
Capoten for High Blood Pressure
My blood pressure has decreased since taking this medication, but not as much as I would have liked.
1.7Patient Review
8/20/2010
Capoten for High Blood Pressure
I took this medication for a few weeks, and while it did help with the swelling in my feet and ankles, I started to experience some very concerning side effects. These included coughing, changes in urine color and odor, and a rash on my scalp. I went to speak to a pharmacist about it who advised me to see a doctor ASAP to change medications.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about capoten

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does capoten slow heart rate?

"18 out of 68 patients experienced a decrease in heart rate after taking captopril, while 2 patients saw an increase. The drug had a significant impact on blood pressure levels, though this did not come with a rise in heart rate."

Answered by AI

Does capoten reduce blood pressure?

"Captopril works by blocking a substance known as angiotensin converting enzyme (ACE). This prevents ACE from constricting blood vessels, which lowers blood pressure and increases blood flow to the heart. Additionally, captopril is used to help treat heart failure by reducing the amount of work the heart has to do."

Answered by AI

What kind of drug is Capoten?

"Capoten is an ACE inhibitor that is used for treating high blood pressure, heart failure, and preventing kidney failure due to high blood pressure and diabetes. Capoten is available in generic form."

Answered by AI

What is Capoten tablets used for?

"Capoten is taken to treat high blood pressure, heart conditions, and kidney conditions associated with diabetes. These chronic illnesses require long term treatment, so it is essential to take Capoten every day as prescribed. Capoten contains the active ingredient captopril."

Answered by AI

Clinical Trials for Capoten

Image of Cambride Cardiac Care Centre in Cambridge, Canada.

Finerenone for Heart Failure

18+
All Sexes
Cambridge, Canada
The goal of this clinical trial is to learn if the drug finerenone (Karendia) can improve heart function in participants who are at risk for heart and kidney disease. The main question it aims to answer is whether adding finerenone to standard-of-care heart failure medical therapies will beneficially alter the heart structure and function of people who have risk factors for heart and kidney complications and whose left side of the heart is enlarged. The researchers will compare finerenone to a placebo (a look-alike substance that contains no drug) to see if finerenone improves heart structure and function. Participants will: * take a finerenone or a placebo tablet once a day for 12 months * have a cardiac magnetic resonance imaging (cMRI; a safe, non-invasive scan to measure heart mass, stiffness and function) test at the beginning of the study and 12 months later * visit the clinic after one, three, six and twelve months to assess overall health and/or perform blood or urine tests
Phase 3
Waitlist Available
Cambride Cardiac Care Centre (+2 Sites)Subodh Verma, MD, PhDBayer
Image of Lakeland Regional Hospital in Lakeland, United States.

Furosemide for Heart Failure

18+
All Sexes
Lakeland, FL
The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared to lower urine sodium target and standard of care. The main questions it aims to answer are: 1. Does targeting a higher urine sodium goal achieve greater natriuresis and diuresis? 2. Does targeting a higher urine sodium goal reduce frequency of hospital readmissions? 3. Does targeting a higher urine sodium goal reduce hospital length of stay? Researchers will compare natriuresis-guided arms with standard of care to see if targeting higher natriuresis goals improves significantly over current practice. Participants will submit urine samples at routine intervals after being given diuretics to evaluate urine sodium concentration. If urine sodium is low then diuretic dose will be increased.
Phase 4
Waitlist Available
Lakeland Regional HospitalAnas Bizanti, MD
Have you considered Capoten clinical trials? We made a collection of clinical trials featuring Capoten, we think they might fit your search criteria.Go to Trials
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Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
Image of Stanford University in Palo Alto, United States.

Decision Support Tool for Type 1 Diabetes

18 - 60
All Sexes
Palo Alto, CA
This study evaluates a digital decision-support tool designed to help individuals with type 1 diabetes prepare for exercise. This netIOB \& Exercise Tool (NEXT) uses glucose data and insulin delivery history to recommend individualized strategies such as carbohydrate intake, insulin adjustments, or delays in exercise start time. Participants will complete three structured aerobic or mixed-exercise sessions using different guidance approaches: (A) published consensus-based standard-of-care guidelines (B) usual personal care routines (C) the NEXT tool The study compares glucose outcomes, safety, and carbohydrate use across these conditions to inform better exercise preparation and support tools for people with diabetes.
Waitlist Available
Has No Placebo
Stanford UniversityRayhan Lal, MD
Have you considered Capoten clinical trials? We made a collection of clinical trials featuring Capoten, we think they might fit your search criteria.Go to Trials
Have you considered Capoten clinical trials? We made a collection of clinical trials featuring Capoten, we think they might fit your search criteria.Go to Trials
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