Capoten

Ventricular Dysfunction, Left, Aldosteronism, Renal Artery Stenosis + 9 more
Treatment
6 FDA approvals
20 Active Studies for Capoten

What is Capoten

CaptoprilThe Generic name of this drug
Treatment SummaryCaptopril is a medication used to lower blood pressure. It works by blocking the enzyme angiotensin-converting enzyme (ACE) which is responsible for converting angiotensin I to angiotensin II. Angiotensin II is part of the renin-angiotensin-aldosterone system (RAAS) and helps to regulate blood pressure. Captopril can be used to treat high blood pressure.
Capotenis the brand name
image of different drug pills on a surface
Capoten Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Capoten
Captopril
1981
183

Approved as Treatment by the FDA

Captopril, otherwise known as Capoten, is approved by the FDA for 6 uses like Ventricular Dysfunction, Left and Heart Attack .
Ventricular Dysfunction, Left
Helps manage ejection fraction of 40% or less Left ventricular dysfunction
Heart Attack
Helps manage Myocardial Infarction
Type 1 Diabetes
Helps manage Type 1 Diabetes Mellitus
Diabetic Nephropathy
Helps manage Diabetic Nephropathy
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Hydrochlorothiazide
Congestive Heart Failure
Helps manage Congestive Heart Failure (CHF)

Effectiveness

How Capoten Affects PatientsCaptopril, an ACE inhibitor, works by blocking the effect of the RAAS, which is a system used by the body to control blood pressure and other things. When the body senses that blood pressure is too low, it releases a hormone called renin which turns into a substance called angiotensin II (ATII). ATII makes the body hold onto more water and salt, which can increase blood pressure. It also causes blood vessels to narrow, further increasing blood pressure. Captopril stops the body from making ATII, which helps lower blood pressure. It also stops the body from breaking down bradykinin,
How Capoten works in the bodyACE inhibitors are drugs that reduce blood pressure. They work by blocking the action of an enzyme called angiotensin-converting enzyme (ACE). There are two kinds of ACE, one found in the body and one found in the testes. ACE inhibitors block both types of ACE, but are more effective at blocking the kind found in the body. Captopril is an ACE inhibitor that binds to ACE and stops it from breaking down another protein called angiotensin I. When ACE is blocked, blood pressure is lowered. Captopril also increases the amount of a hormone called renin, which helps the body release more water

When to interrupt dosage

The advised measure of Capoten is contingent upon the recognized disorder, including Heart Attack, Non-STEMI Acute Coronary Syndrome and Aldosteronism. The measure of dosage is variable, according to the technique of delivery (e.g. Oral or Tablet - Oral) laid out in the table beneath.
Condition
Dosage
Administration
Heart Attack
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Hypertensive crisis
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Hypertensive disease
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Non-STEMI Acute Coronary Syndrome
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Ventricular Dysfunction, Left
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Congestive Heart Failure
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Renal Artery Stenosis
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Aldosteronism
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Congestive Heart Failure
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Diabetic Nephropathy
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Type 1 Diabetes
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Raynaud's Phenomenon
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated

Warnings

There are 20 known major drug interactions with Capoten.
Common Capoten Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Captopril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Captopril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Captopril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Captopril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Captopril.
Capoten Toxicity & Overdose RiskTaking too much of this drug may result in vomiting and low blood pressure. Other possible side effects include a rash, changes in taste, coughing, stomach upset, and swelling of the face and tongue.
image of a doctor in a lab doing drug, clinical research

Capoten Novel Uses: Which Conditions Have a Clinical Trial Featuring Capoten?

554 active trials are currently being conducted to assess the potential of Capoten to treat Type 1 Diabetes, Myocardial Infarction and Hypertensive Crisis.
Condition
Clinical Trials
Trial Phases
Type 1 Diabetes
146 Actively Recruiting
Phase 3, Phase 1, Early Phase 1, Not Applicable, Phase 2, Phase 4
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
Renal Artery Stenosis
0 Actively Recruiting
Hypertensive disease
18 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Non-STEMI Acute Coronary Syndrome
1 Actively Recruiting
Phase 3
Heart Attack
55 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Hypertensive crisis
0 Actively Recruiting
Raynaud's Phenomenon
1 Actively Recruiting
Phase 4
Congestive Heart Failure
22 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Ventricular Dysfunction, Left
0 Actively Recruiting
Aldosteronism
0 Actively Recruiting
Congestive Heart Failure
315 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4

Capoten Reviews: What are patients saying about Capoten?

4Patient Review
1/24/2008
Capoten for High Blood Pressure
My blood pressure was significantly lower after taking this medication.
2.3Patient Review
11/12/2007
Capoten for High Blood Pressure
My blood pressure has decreased since taking this medication, but not as much as I would have liked.
1.7Patient Review
8/20/2010
Capoten for High Blood Pressure
I took this medication for a few weeks, and while it did help with the swelling in my feet and ankles, I started to experience some very concerning side effects. These included coughing, changes in urine color and odor, and a rash on my scalp. I went to speak to a pharmacist about it who advised me to see a doctor ASAP to change medications.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about capoten

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does capoten slow heart rate?

"18 out of 68 patients experienced a decrease in heart rate after taking captopril, while 2 patients saw an increase. The drug had a significant impact on blood pressure levels, though this did not come with a rise in heart rate."

Answered by AI

Does capoten reduce blood pressure?

"Captopril works by blocking a substance known as angiotensin converting enzyme (ACE). This prevents ACE from constricting blood vessels, which lowers blood pressure and increases blood flow to the heart. Additionally, captopril is used to help treat heart failure by reducing the amount of work the heart has to do."

Answered by AI

What kind of drug is Capoten?

"Capoten is an ACE inhibitor that is used for treating high blood pressure, heart failure, and preventing kidney failure due to high blood pressure and diabetes. Capoten is available in generic form."

Answered by AI

What is Capoten tablets used for?

"Capoten is taken to treat high blood pressure, heart conditions, and kidney conditions associated with diabetes. These chronic illnesses require long term treatment, so it is essential to take Capoten every day as prescribed. Capoten contains the active ingredient captopril."

Answered by AI

Clinical Trials for Capoten

Have you considered Capoten clinical trials? We made a collection of clinical trials featuring Capoten, we think they might fit your search criteria.
Have you considered Capoten clinical trials? We made a collection of clinical trials featuring Capoten, we think they might fit your search criteria.
Have you considered Capoten clinical trials? We made a collection of clinical trials featuring Capoten, we think they might fit your search criteria.