Sensipar

Hypercalcemia, Dialysis therapy, Parathyroidectomy + 4 more
Treatment
20 Active Studies for Sensipar

What is Sensipar

CinacalcetThe Generic name of this drug
Treatment SummaryCinacalcet is a medication used to treat high levels of calcium in the blood caused by either parathyroid tumors or kidney failure. It is sold under the brand names Sensipar® in North America and Australia, and Mimpara® in Europe.
Sensiparis the brand name
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Sensipar Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sensipar
Cinacalcet
2004
88

Effectiveness

How Sensipar Affects PatientsCinacalcet is a drug that acts like calcium in the body and is used to treat a kidney disorder called secondary hyperparathyroidism (HPT). This disorder causes a build-up of calcium and phosphorus which can lead to bone damage. Cinacalcet works by increasing the body's sensitivity to calcium, reducing calcium levels in the blood and helping to prevent further bone damage. Studies have shown that reducing calcium levels with Cinacalcet also helps reduce bone turnover and bone fibrosis.
How Sensipar works in the bodyCinacalcet helps lower parathyroid hormone levels. It does this by increasing the sensitivity of cells to calcium, which in turn inhibits the secretion of PTH. As a result, calcium levels in the blood also decrease.

When to interrupt dosage

The endorsed dose of Sensipar is dependent upon the identified condition, including Dialysis therapy, Hyperparathyroidism, Secondary and Chronic Kidney Disease. The amount of dosage is subject to the administration approach (e.g. Tablet - Oral or Tablet) featured in the table beneath.
Condition
Dosage
Administration
Dialysis therapy
30.0 mg, , 60.0 mg, 90.0 mg, 2.5 mg, 5.0 mg, 1.0 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Hypercalcemia
30.0 mg, , 60.0 mg, 90.0 mg, 2.5 mg, 5.0 mg, 1.0 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Parathyroidectomy
30.0 mg, , 60.0 mg, 90.0 mg, 2.5 mg, 5.0 mg, 1.0 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Chronic Kidney Disease
30.0 mg, , 60.0 mg, 90.0 mg, 2.5 mg, 5.0 mg, 1.0 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Hyperparathyroidism
30.0 mg, , 60.0 mg, 90.0 mg, 2.5 mg, 5.0 mg, 1.0 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Parathyroid Neoplasms
30.0 mg, , 60.0 mg, 90.0 mg, 2.5 mg, 5.0 mg, 1.0 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Hyperparathyroidism, Secondary
30.0 mg, , 60.0 mg, 90.0 mg, 2.5 mg, 5.0 mg, 1.0 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral

Warnings

Sensipar Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Hypocalcemia
Do Not Combine
Hypocalcemia
Do Not Combine
There are 20 known major drug interactions with Sensipar.
Common Sensipar Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Cinacalcet.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Cinacalcet.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Cinacalcet.
Acetaminophen
Major
The metabolism of Acetaminophen can be decreased when combined with Cinacalcet.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Cinacalcet.
Sensipar Toxicity & Overdose RiskCinacalcet can be taken up to 300mg once a day, even for those on dialysis. Taking too much of the drug may lower calcium levels in the body.
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Sensipar Novel Uses: Which Conditions Have a Clinical Trial Featuring Sensipar?

At present, 121 active trials are assessing the potential of Sensipar in treating Chronic Kidney Disease, Hypercalcemia and providing Dialysis therapy.
Condition
Clinical Trials
Trial Phases
Chronic Kidney Disease
105 Actively Recruiting
Not Applicable, Phase 1, Phase 3, Phase 2, Phase 4, Early Phase 1
Hypercalcemia
1 Actively Recruiting
Phase 4
Dialysis therapy
3 Actively Recruiting
Not Applicable
Hyperparathyroidism, Secondary
4 Actively Recruiting
Phase 3, Not Applicable
Hyperparathyroidism
1 Actively Recruiting
Phase 4
Parathyroidectomy
0 Actively Recruiting
Parathyroid Neoplasms
0 Actively Recruiting

Sensipar Reviews: What are patients saying about Sensipar?

5Patient Review
6/4/2013
Sensipar for High Amount of Calcium in the Blood from Increased Activity of the Parathyroid Gland
This medication has really allowed me to improve my quality of life. After a few weeks, all the negative side effects I was experiencing- like fatigue, lack of energy, irritation, and depression- went away.
5Patient Review
10/19/2018
Sensipar for High Amount of Calcium in the Blood from Increased Activity of the Parathyroid Gland
I'm worried that this medication is harming my kidneys, even though I don't have renal failure or cod.
5Patient Review
9/12/2012
Sensipar for Hyperparathyroidism caused by Chronic Renal Failure with Dialysis
I have stage 5 CKD and take sensipar with my largest meal of the day. I've experienced no side effects at all, and it has really helped me feel better overall. Along with sensipar, I also take Calcitriol 3 times a week, and a potassium supplement and Nephro vitamin daily.
4.3Patient Review
9/14/2011
Sensipar for Hyperparathyroidism caused by Chronic Renal Failure with Dialysis
This medication has improved my PTH, Phosphorus, and Calcium numbers. I haven't had any side effects. This saved me from surgery.
4.3Patient Review
7/13/2016
Sensipar for High Amount of Calcium in the Blood from Increased Activity of the Parathyroid Gland
My calcium levels have dropped significantly since taking this medication, and I'm now also experiencing full-mouth hyperplasia. My gums are swollen and no amount of dental visits have helped. I can almost pinpoint this problem since I began taking Sensipar, but have not found any other back-up. Am curious if anyone else has had a problem with their teeth and/or gums while taking this drug.
View All Reviews
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Patient Q&A Section about sensipar

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who should not take Sensipar?

"Do not take Sensipar if you have low levels of calcium in your blood. Tell your doctor if you have any of the following conditions before taking Sensipar: high blood pressure, heart disease, heart failure, a heart rhythm disorder, liver disease, or a history of seizures."

Answered by AI

What is the difference between Sensipar and cinacalcet?

"The generic name for Sensipar is Cinacalcet. The drug comes in pill form in three strengths (30mg, 60mg, and 90mg). It is designed for the treatment of secondary hyperparathyroidism."

Answered by AI

When do you give Sensipar?

"You should take Sensipar once a day, at one of the 5 recommended daily doses. The tablets should be taken whole, with food or shortly after a meal. It's best to take Sensipar at the same time, with the same meal, every day. You should take Sensipar at least 12 hours before your PTH blood test."

Answered by AI

What is the drug Sensipar used for?

"Sensipar is indicated for the treatment of secondary hyperparathyroidism in adult patients with chronic kidney disease who are on dialysis. Sensipar should not be used in patients with chronic kidney disease who are not on dialysis because they are at an increased risk for low calcium levels."

Answered by AI

Clinical Trials for Sensipar

Have you considered Sensipar clinical trials? We made a collection of clinical trials featuring Sensipar, we think they might fit your search criteria.
Have you considered Sensipar clinical trials? We made a collection of clinical trials featuring Sensipar, we think they might fit your search criteria.
Have you considered Sensipar clinical trials? We made a collection of clinical trials featuring Sensipar, we think they might fit your search criteria.
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