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What is Ferrlecit
Sodium ferric gluconate complexThe Generic name of this drug
Treatment SummarySodium ferric gluconate complex is an iron-based medication used to treat iron deficiency anemia. It is composed of iron oxide hydrate, sucrose, and gluconate molecules with a ratio of two iron molecules to one gluconate molecule. It is prescribed to adult and pediatric patients over the age of 6 years with chronic kidney disease who are receiving hemodialysis and supplemental epoetin therapy.
Ferrlecitis the brand name
Ferrlecit Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ferrlecit
Sodium ferric gluconate complex
1999
8
Approved as Treatment by the FDA
Sodium ferric gluconate complex, otherwise known as Ferrlecit, is approved by the FDA for 3 uses including Epoetin Treatment and Iron Deficiency Anemia .Epoetin Treatment
Iron Deficiency Anemia
Chronic Hemodialysis (ESRD)
Effectiveness
How Ferrlecit Affects PatientsSodium ferric gluconate complex is a drug that helps the body to get more iron. Iron is necessary for the body to make hemoglobin which carries oxygen, as well as for certain chemical reactions in the body. Taking this drug can increase the number of red blood cells and help the body use iron better.
How Ferrlecit works in the bodyMacrophages in the body take up sodium ferric gluconate and break it down. The iron from this complex is then used to make ferritin, transferrin or hemoglobin. Sodium ferric gluconate also helps create more red blood cells by binding with hemoglobin.
When to interrupt dosage
The proposed amount of Ferrlecit is contingent upon the diagnosed situation, including Iron deficiency anemia, Chemotherapy and Iron Deficiency Anemia. The dosage fluctuates as per the method of delivery mentioned in the table underneath.Condition
Dosage
Administration
Epoetin Treatment
, 12.5 mg/mL, 12.5 mg
, Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Iron Deficiency Anemia
, 12.5 mg/mL, 12.5 mg
, Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Chemotherapy
, 12.5 mg/mL, 12.5 mg
, Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Iron Deficiency Anemia
, 12.5 mg/mL, 12.5 mg
, Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Chronic Hemodialysis (ESRD)
, 12.5 mg/mL, 12.5 mg
, Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Warnings
Ferrlecit ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Sodium Ferric Gluconate Complex may interact with Pulse Frequency
Pulse Frequency
Do Not Combine
Common Ferrlecit Drug Interactions
Drug Name
Risk Level
Description
Acebutolol
Moderate
The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Acebutolol.
Aldesleukin
Moderate
The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Aldesleukin.
Aliskiren
Moderate
The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Aliskiren.
Alprenolol
Moderate
The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Alprenolol.
Ambrisentan
Moderate
The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Ambrisentan.
Ferrlecit Toxicity & Overdose RiskFerrlecit is not removable through dialysis. There is no known information on Ferrlecit overdose in humans, however it can lead to the build-up of iron in the body, which can cause harm. Taking more than 125 mg of Ferrlecit can increase the risk of adverse side effects. In animal studies, doses of 125 mg/kg, 78.8 mg/kg, 62.5 mg/kg, and 250 mg/kg of Ferrlecit have been found to cause death. Signs of acute toxicity may include a decrease in activity, unsteady walking, faster breathing, shaking, and seizures.
Ferrlecit Novel Uses: Which Conditions Have a Clinical Trial Featuring Ferrlecit?
Currently, 219 active clinical trials are investigating the potential of Ferrlecit to treat Iron deficiency anemia, Iron Deficiency Anemia induced by Chemotherapy.Condition
Clinical Trials
Trial Phases
Chronic Hemodialysis (ESRD)
0 Actively Recruiting
Chemotherapy
2 Actively Recruiting
Not Applicable
Iron Deficiency Anemia
114 Actively Recruiting
Phase 1, Not Applicable, Phase 2, Phase 3, Phase 4, Early Phase 1
Iron Deficiency Anemia
12 Actively Recruiting
Phase 3, Phase 4, Not Applicable, Phase 2
Epoetin Treatment
0 Actively Recruiting
Ferrlecit Reviews: What are patients saying about Ferrlecit?
5Patient Review
11/17/2016 I didn't experience any negative effects from taking Benedryl.
3.7Patient Review
7/1/2013 I get iron infusions every 6 months, and this is the product my MD has had me on since 2007. No reactions to it, except for post-infusion edema twice last year. I needed Lasix after those two treatments, but otherwise no problems.
3.7Patient Review
2/17/2011 The only downside to Ferrlecit is that I've started constantly tasting metal. But other than that, it's much improved my quality of life.
3.3Patient Review
4/10/2011 I've been getting IV infusions for two years now, ever since my Feritin level hit zero. I initially had a bad reaction to the treatment, but we halved the dosage and added saline before doubling the infusion time. That worked for a while, but I had another bad reaction this week. I'm still ill after two more infusions, and I have six more scheduled. Recently found out I had Caliac so I am hopeful this may all end but I have been told I may have to be "filled-up" for the rest of my life.
3Patient Review
4/24/2011 I've completed five treatments and have yet to feel any benefits. I'm seven years post-gastric bypass surgery and recently fell off my nutritional diet, so I'm now iron deficient. Yesterday and today were very active days for me, and now my feet, calves, and back are killing me. I took some Aleve a little while ago, but it hasn't kicked in yet. If this doesn't work soon, I won't be getting any sleep tonight.
3Patient Review
7/31/2011 I completed an eight-week treatment plan of weekly infusions and began to feel more energetic after the third week. I did have some joint pain, sleepiness, and intense cravings for meat after the first treatment, but nothing unmanageable. However, my fifth infusion was delivered too quickly and I developed intense joint pain (worse than week one), dizziness, and fatigue immediately. Overall, I'm pleased with the results; though not all of my iron numbers increased as a result of this treatment, most did.
3Patient Review
6/12/2014 I've now completed 3/8 of my treatments. Unfortunately, each time I get an infusion I also experience some nasty side effects including a headache, nausea, and fatigue that last for about 24 hours. Additionally, the joint pain I was hoping to alleviate with these treatments has only gotten worse in the days following each treatment.
3Patient Review
1/7/2014 Yesterday was my third treatment and I got a steroid and Benadryl as well. Unfortunately, I had an awful headache afterward that has lingered into today a bit. On top of that, last night I had terrible sweats that soaked my sheets! Although I'm feeling tired, it's not as bad as it was before the IV.
2.7Patient Review
8/12/2015 The concentration of benzyl alcohol in Ferrlicet is WAY too high. This prevents us from getting the required dose. Our prescribing doctors have brought this problem up with the company, but they have NO explanation for the extremely high amount of this preservative. We must infuse this at a rate no higher than 42 ml/hour or our pediatric patient will experience severe headache and other symptoms. Our pharmacists say the amount of benzyl alcohol is orders of magnitude higher than it should be.
2.7Patient Review
11/15/2011 I experienced nausea and dizziness. I felt very weak afterwards.
1Patient Review
10/12/2011 I had a really severe reaction to this Ferrlecit infusion, despite the fact that they gave me steroids and benadryl beforehand. My heart rate dropped, I had chest pain, and blisters all over my body. It was awful.
1Patient Review
10/24/2016 After the three hour infusion, I had a severe reaction. Hives, high heart rate, and difficulty breathing. My hip also started hurting really badly. went to the ER and they said it was anaphylactic shock.
1Patient Review
1/21/2012 I am so exhausted and feeble before I get treatment...it takes too long before I feel normal again. This happens one month out of every three, and it's really frustrating.
1Patient Review
4/23/2012 I had a severe reaction to this medication and it was honestly the worst experience of my life. I hope that nobody else has to go through what I did.
Patient Q&A Section about ferrlecit
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Ferrlecit used for?
"This medication is used to treat anemia in people with long-term kidney disease who are using a certain class of drug. You may need extra iron because you lose blood during kidney dialysis."
Answered by AI
What is the cost of Ferrlecit?
"The price of Ferrlecit intravenous solution (12.5 mg/mL) is approximately $344 for 50 milliliters, depending on the pharmacy you visit. The price is for cash paying customers only and is not valid with insurance plans."
Answered by AI
How do you administer Ferrlecit?
"Ferrlecit should be diluted in 100 mL of 0.9% sodium chloride and given by intravenous infusion over the course of one hour per dialysis session. It can also be given undiluted as a slow intravenous injection over the course of one hour per dialysis session."
Answered by AI
What type of drug is Ferrlecit?
"Ferrlecit is a type of iron replacement product used to treat iron deficiency anemia in adults and children 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy."
Answered by AI