Ryanodex

Malignant Hyperthermia, Muscle Spasticity, Malignant Hyperthermia + 4 more
Treatment
20 Active Studies for Ryanodex

What is Ryanodex

DantroleneThe Generic name of this drug
Treatment SummaryDantrolene is a medicine that does not work the same way as other drugs in its class, such as phenytoin. It is made from a chemical called a hydantoin derivative.
Dantrolene Sodiumis the brand name
Ryanodex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dantrolene Sodium
Dantrolene
2005
36

Effectiveness

How Ryanodex Affects PatientsDantrolene is a medicine that helps relax the muscles. It is the only treatment for a dangerous condition called malignant hyperthermia. It works by interfering with the release of calcium from the muscles, which helps restore normal levels of calcium in the cells. In malignant hyperthermia, it is believed that certain drugs (like general anesthetics and muscle relaxants) cause an increase in calcium levels in the muscle cells, which can lead to a dangerous situation. Dantrolene helps bring the calcium levels back to normal.
How Ryanodex works in the bodyDantrolene works on muscle cells to prevent them from contracting. It does this by binding to a receptor in the muscle, which stops calcium from being released. Calcium is needed for muscles to contract, so without it, the muscle cannot move.

When to interrupt dosage

The optimal dose of Ryanodex is contingent upon the diagnosed condition, including Stroke, Spasticity and Spinal Cord Injury. The amount of dosage is reliant on the mode of delivery (e.g. Capsule - Oral or Injection, Solution - Intravenous) featured in the table underneath.
Condition
Dosage
Administration
Malignant Hyperthermia
, 25.0 mg, 50.0 mg, 100.0 mg, 2.0 mg/mL, 250.0 mg/mL, 20.0 mg
, Oral, Capsule, Capsule - Oral, Intravenous, Injection, Injection - Intravenous, Injection, suspension, Injection, suspension - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, solution, Injection, solution - Intravenous
Malignant Hyperthermia
, 25.0 mg, 50.0 mg, 100.0 mg, 2.0 mg/mL, 250.0 mg/mL, 20.0 mg
, Oral, Capsule, Capsule - Oral, Intravenous, Injection, Injection - Intravenous, Injection, suspension, Injection, suspension - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, solution, Injection, solution - Intravenous
Multiple Sclerosis
, 25.0 mg, 50.0 mg, 100.0 mg, 2.0 mg/mL, 250.0 mg/mL, 20.0 mg
, Oral, Capsule, Capsule - Oral, Intravenous, Injection, Injection - Intravenous, Injection, suspension, Injection, suspension - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, solution, Injection, solution - Intravenous
Stroke
, 25.0 mg, 50.0 mg, 100.0 mg, 2.0 mg/mL, 250.0 mg/mL, 20.0 mg
, Oral, Capsule, Capsule - Oral, Intravenous, Injection, Injection - Intravenous, Injection, suspension, Injection, suspension - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, solution, Injection, solution - Intravenous
Spinal Cord Injury
, 25.0 mg, 50.0 mg, 100.0 mg, 2.0 mg/mL, 250.0 mg/mL, 20.0 mg
, Oral, Capsule, Capsule - Oral, Intravenous, Injection, Injection - Intravenous, Injection, suspension, Injection, suspension - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, solution, Injection, solution - Intravenous
Cerebral Palsy
, 25.0 mg, 50.0 mg, 100.0 mg, 2.0 mg/mL, 250.0 mg/mL, 20.0 mg
, Oral, Capsule, Capsule - Oral, Intravenous, Injection, Injection - Intravenous, Injection, suspension, Injection, suspension - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, solution, Injection, solution - Intravenous
Muscle Spasticity
, 25.0 mg, 50.0 mg, 100.0 mg, 2.0 mg/mL, 250.0 mg/mL, 20.0 mg
, Oral, Capsule, Capsule - Oral, Intravenous, Injection, Injection - Intravenous, Injection, suspension, Injection, suspension - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, solution, Injection, solution - Intravenous

Warnings

Ryanodex has six contraindications, so it should not be employed in combination with the conditions presented in the below table.Ryanodex Contraindications
Condition
Risk Level
Notes
Muscle Spasticity
Do Not Combine
Muscle Spasticity
Do Not Combine
Cirrhosis
Do Not Combine
Hepatitis
Do Not Combine
Locomotion
Do Not Combine
Liver Diseases
Do Not Combine
There are 20 known major drug interactions with Ryanodex.
Common Ryanodex Drug Interactions
Drug Name
Risk Level
Description
Agmatine
Major
The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Agmatine.
Amiodarone
Major
The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Amiodarone.
Amlodipine
Major
The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Amlodipine.
Aranidipine
Major
The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Aranidipine.
Azelastine
Major
Dantrolene may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ryanodex Toxicity & Overdose RiskThe toxic dose of this drug in rats is 7400mg/kg. Signs of an overdose include muscle weakness, confusion, vomiting, diarrhea, and the presence of crystals in the urine.

Ryanodex Novel Uses: Which Conditions Have a Clinical Trial Featuring Ryanodex?

258 active clinical trials are examining the possible benefits of Ryanodex in treating Multiple Sclerosis, Spinal Cord Injury and Spasticity-related conditions.
Condition
Clinical Trials
Trial Phases
Muscle Spasticity
0 Actively Recruiting
Multiple Sclerosis
116 Actively Recruiting
Phase 3, Not Applicable, Phase 4, Phase 2, Phase 1, Early Phase 1
Malignant Hyperthermia
0 Actively Recruiting
Malignant Hyperthermia
0 Actively Recruiting
Cerebral Palsy
0 Actively Recruiting
Stroke
8 Actively Recruiting
Phase 4, Phase 1, Not Applicable
Spinal Cord Injury
55 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Early Phase 1, Phase 1

Patient Q&A Section about ryanodex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How do you administer RYANODEX?

"The recommended dosage of RYANODEX® for adults and children is 1 mg/kg, given as an intravenous push. If the person continues to have physiologic and metabolic abnormalities associated with MH, additional intravenous doses up to a maximum of 10 mg/kg may be given."

Answered by AI

Is RYANODEX the same as dantrolene?

"RYANODEX® uses a unique technology that helps it to address deficiencies that other dantrolene sodium products have."

Answered by AI

What is RYANODEX used for?

"The drug RYANODEX® is indicated for the treatment of a condition called malignant hyperthermia. This condition is treated by using appropriate supportive measures in addition to the drug. RYANODEX® is also indicated for the prevention of malignant hyperthermia in patients who are at a high risk for developing the condition."

Answered by AI

What do you mix RYANODEX with?

"What is the process for reconstituting RYANODEX®?

To reconstitute RYANODEX®, add 5 mL of sterile water for injection to the vial. Shake the vial until the RYANODEX® is mixed thoroughly (should take less than 10 seconds)."

Answered by AI

Clinical Trials for Ryanodex

Have you considered Ryanodex clinical trials? We made a collection of clinical trials featuring Ryanodex, we think they might fit your search criteria.
Have you considered Ryanodex clinical trials? We made a collection of clinical trials featuring Ryanodex, we think they might fit your search criteria.
Have you considered Ryanodex clinical trials? We made a collection of clinical trials featuring Ryanodex, we think they might fit your search criteria.
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