Transcranial Direct Current Stimulation for Depression in Multiple Sclerosis
What You Need to Know Before You Apply
What is the purpose of this trial?
This project is a double-blind, sham-controlled, parallel-arm, randomized controlled trial. We will recruit n=170 people living with MS, who are experiencing an episode of depression in the context of a major depressive episode (MDE). Using our remotely supervised (RS) tDCS protocol, enrolled participants will complete 30 days of 30-minute tDCS (2.0, DLPFC left anodal) while listening to mindfulness meditation. Over the course of the study, participants will complete assessments of depression and MS symptoms. Participants will be randomized 1:1 active:sham tDCS.
Will I have to stop taking my current medications?
The trial requires that you have been on stable antidepressant and disease-modifying therapies (DMTs) for at least 30 days before joining, so you should not stop taking these medications.
Is transcranial direct current stimulation (tDCS) safe for humans?
Research shows that transcranial direct current stimulation (tDCS) is generally safe for humans, with no serious adverse effects reported in over 33,200 sessions and 1,000 subjects, including vulnerable populations. The amount of electricity used in tDCS is much lower than levels that could cause brain injury, ensuring safety when used at standard intensities and durations.12345
How does the treatment transcranial direct current stimulation (tDCS) differ from other treatments for depression in multiple sclerosis?
Transcranial direct current stimulation (tDCS) is unique because it involves delivering weak electrical currents through the scalp to modulate brain activity, which can improve mood, cognitive function, and reduce fatigue in multiple sclerosis patients. Unlike traditional drug treatments, tDCS is non-invasive and can have lasting effects on brain excitability without the need for medication.23678
What data supports the effectiveness of the treatment Transcranial Direct Current Stimulation (tDCS) for depression in Multiple Sclerosis?
Who Is on the Research Team?
Leigh Charvet, PhD
Principal Investigator
NYU Langone Health
Are You a Good Fit for This Trial?
This trial is for people with Multiple Sclerosis (MS) who are also dealing with depression. Participants must be experiencing a major depressive episode to qualify. The study aims to include 170 individuals and requires them to complete daily sessions of tDCS while listening to mindfulness meditation for 30 days.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive 30 days of 30-minute daily (M-F) tDCS sessions paired with mindfulness meditation
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Transcranial Direct Current Stimulation (tDCS)
Find a Clinic Near You
Who Is Running the Clinical Trial?
NYU Langone Health
Lead Sponsor
National Multiple Sclerosis Society
Collaborator