45 Participants Needed

Computer-Assisted Cognitive Training for Brain Tumor

Recruiting at 30 trial locations
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial studies how well an adaptive computer-based training program works for younger patients with brain tumors who have had radiation therapy. The program adjusts its difficulty based on the patient's performance to help improve their memory and attention.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Is computer-assisted cognitive training safe for humans?

Computer-assisted cognitive training has been used safely in various studies with cancer patients, including those with brain tumors and breast cancer. Participants generally reported high satisfaction and adherence, with no significant safety concerns mentioned in the studies.12345

How does Computer-Assisted Cognitive Training differ from other treatments for brain tumors?

Computer-Assisted Cognitive Training is unique because it uses technology to help improve cognitive functions in brain tumor patients, offering a flexible and individualized approach that can be accessed remotely. This treatment focuses on enhancing cognitive skills like attention and memory through interactive exercises, making it more accessible and engaging compared to traditional therapies.26789

What data supports the effectiveness of the treatment Computer-Assisted Cognitive Training for brain tumor patients?

Research shows that computer-assisted cognitive training can be effective in improving cognitive function in patients with brain tumors and other neurological conditions. A study on the ReMind app, a cognitive rehabilitation program for brain tumor patients, found that most participants rated the program as 'good' or 'excellent' and would recommend it to others, suggesting its potential effectiveness.126710

Who Is on the Research Team?

KK

Kristina K Hardy

Principal Investigator

Children's Oncology Group

Are You a Good Fit for This Trial?

This trial is for young patients with brain tumors who have finished radiation therapy within the last 4 months. They need to have a caregiver, access to a phone, and understand English. Patients with traumatic brain injury before their tumor diagnosis, pontine glioma, IQ < 70 or severe disabilities that prevent computer use are not eligible.

Inclusion Criteria

All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met
I have someone willing to help me during my treatment.
I have a phone and can be contacted.
See 4 more

Exclusion Criteria

Patients with an estimated survival of less than one year
Patients with a history of traumatic brain injury prior to tumor diagnosis
I have a brain tumor located in the pons.
See 2 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo a home-based, computerized, interactive training program for 5-9 weeks, with 3-5 sessions of 15-45 minutes each week. The program is either adaptive or non-adaptive, depending on the arm.

5-9 weeks
Weekly telephone meetings with interventional coach

Follow-up

Participants are monitored for safety and effectiveness after treatment, with assessments at baseline, after completion, and at 6 months post-treatment.

6 months

What Are the Treatments Tested in This Trial?

Interventions

  • Computer-Assisted Cognitive Training
Trial Overview The study compares an adaptive computerized cognitive training program against a non-adaptive one to see if they can improve mental function and quality of life after brain radiation therapy in younger patients with brain tumors.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Group I: Arm II (non-adaptive training program)Experimental Treatment5 Interventions
Group II: Arm I (interactive training program)Experimental Treatment5 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Children's Oncology Group

Lead Sponsor

Trials
467
Recruited
241,000+

National Cancer Institute (NCI)

Collaborator

Trials
14,080
Recruited
41,180,000+

Published Research Related to This Trial

The ReMind app, an iPad-based cognitive rehabilitation program, was found to be feasible for patients with primary brain tumors, with 85% of participants rating it as 'good' or 'excellent' and expressing willingness to recommend it to others.
In a pilot study involving 15 patients, participants completed a significant portion of the training (71% strategy training and 76% retraining), indicating good adherence, although some found the exercises too easy, leading to plans for more challenging content in future evaluations.
Feasibility of the evidence-based cognitive telerehabilitation program Remind for patients with primary brain tumors.van der Linden, SD., Sitskoorn, MM., Rutten, GM., et al.[2019]
An 8-week home-based computerized cognitive training (CCT) program was assessed for feasibility among 19 patients recently treated for hematological malignancies, but adherence was low, with only one participant fully engaging with the program.
Participants found the CCT program easy to follow and expressed a need for improvements, such as personalized feedback and peer support, to enhance adherence, indicating that while CCT may be beneficial, additional support strategies are necessary for effective implementation in the post-treatment phase.
Computerized cognitive training in post-treatment hematological cancer survivors: a feasibility study.Mayo, SJ., Rourke, SB., Atenafu, EG., et al.[2021]
In a study of 38 brain tumor patients, those who underwent virtual reality (VR) training alongside computer-based cognitive rehabilitation showed significant improvements in various cognitive tests compared to those who only received the computer program.
The VR group demonstrated better results in specific cognitive areas, such as visual and auditory attention, memory span, and processing speed, suggesting that VR training can enhance cognitive recovery in brain tumor patients.
Effect of virtual reality on cognitive dysfunction in patients with brain tumor.Yang, S., Chun, MH., Son, YR.[2022]

Citations

Feasibility of the evidence-based cognitive telerehabilitation program Remind for patients with primary brain tumors. [2019]
Preliminary exploration of a computerized cognitive battery and comparison with traditional testing in patients with high-grade glioma. [2022]
Computerized cognitive training in post-treatment hematological cancer survivors: a feasibility study. [2021]
Effect of virtual reality on cognitive dysfunction in patients with brain tumor. [2022]
[Computer-assisted neuropsychological training in neurological rehabilitation]. [2006]
Cognitive rehabilitation program to improve cognition of cancer patients treated with chemotherapy: A 3-arm randomized trial. [2021]
Disseminability of computerized cognitive training: Performance across coaches. [2020]
Effect of cognitive training on patients with breast cancer reporting cognitive changes: a systematic review and meta-analysis. [2023]
[Microcomputer and rehabilitation of cognitive cerebral performance disorders]. [2015]
10.United Statespubmed.ncbi.nlm.nih.gov
Cognitive rehabilitation for early post-surgery inpatients affected by primary brain tumor: a randomized, controlled trial. [2021]
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