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Procedure

Ischemic Conditioning for Stroke

N/A

Recruiting

Led By Sangeetha Madhavan, PT, PhD

Research Sponsored by University of Illinois at Chicago

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Residual hemiparetic gait deficits (e.g., abnormal gait pattern)

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up during each real and sham ischemic conditioning session, pain scores will be reported for each participant during intervals of blow flow restriction and reperfusion through study completion, an average of 1 year.

Awards & highlights

Study Summary

This trial aims to test if blood flow restriction, known as ischemic conditioning, can be used to improve walking ability in stroke patients. The researchers want to see if this technique can change brain activity in

Who is the study for?

This trial is for individuals aged 18-35 who have had a stroke. It's not open to those with other neurological impairments. Participants will undergo sessions of ischemic conditioning and aerobic exercise to see if these can improve their walking ability after the stroke.Check my eligibility

What is being tested?

The study tests whether restricting blood flow using a cuff on the thigh (ischemic conditioning) or doing aerobic exercise can help change brain activity and enhance motor skills like strength, control, and speed in people recovering from a stroke.See study design

What are the potential side effects?

Possible side effects may include discomfort from the pressure cuff used during ischemic conditioning or general fatigue post-exercise. The impact on each individual could vary.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have difficulty walking due to partial paralysis.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ during each real and sham ischemic conditioning session, pain scores will be reported for each participant during intervals of blow flow restriction and reperfusion through study completion, an average of 1 year.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~during each real and sham ischemic conditioning session, pain scores will be reported for each participant during intervals of blow flow restriction and reperfusion through study completion, an average of 1 year.

This trial's timeline: 3 weeks for screening, Varies for treatment, and during each real and sham ischemic conditioning session, pain scores will be reported for each participant during intervals of blow flow restriction and reperfusion through study completion, an average of 1 year. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in ankle motor control

Change in corticomotor excitability

Change in intracortical inhibition

+2 more

Secondary outcome measures

Change in gait speed

Numerical Rating Scale (NRS) for Pain

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Placebo Group

Group I: Ischemic ConditioningExperimental Treatment1 Intervention

While seated, a rapid inflation cuff, similar to those used to measure blood pressure, will be placed around the paretic thigh to perform real ischemic conditioning. The pressure of the cuff will be increased for 5 minutes followed by no pressure for 5 minutes, repeated 5 times for a total of 50 minutes.

Group II: Aerobic ExerciseActive Control1 Intervention

Participants will perform thirty minutes of moderate intensity continuous aerobic exercise using a recumbent stepper.

Group III: Sham Ischemic ConditioningPlacebo Group1 Intervention

While seated, a rapid inflation cuff, similar to those used to measure blood pressure, will be placed around the paretic thigh to perform sham or fake ischemic conditioning. The pressure of the cuff will be increased for 5 minutes followed by no pressure for 5 minutes, repeated 5 times for a total of 50 minutes.

0 / 1Eligibility criteria met

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Who is running the clinical trial?

University of Illinois at ChicagoLead Sponsor

609 Previous Clinical Trials

1,559,259 Total Patients Enrolled

18 Trials studying Stroke

2,201 Patients Enrolled for Stroke

Sangeetha Madhavan, PT, PhDPrincipal InvestigatorUniversity of Illinois at Chicago

1 Previous Clinical Trials

50 Total Patients Enrolled

1 Trials studying Stroke

50 Patients Enrolled for Stroke

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any available openings for patients to participate in this medical study?

"As indicated by clinicaltrials.gov, this study is currently seeking volunteers. Originally uploaded on March 30th, 2024, the most recent update occurred on February 20th of that same year."

Answered by AI

What is the total number of individuals who are currently enrolled as participants in this medical study?

"The details on clinicaltrials.gov specify that this medical study is presently enrolling participants. The trial was first listed on March 30, 2024, with the latest update made on February 20, 2024. Recruitment aims to enlist 50 individuals from a single site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Motor and Neurophysiological Changes After Ischemic Conditioning in Individuals With Stroke

Sangeetha Madhavan 2024. "Motor and Neurophysiological Changes After Ischemic Conditioning in Individuals With Stroke". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05906602.

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