MIND Diet for Multiple Sclerosis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how a MIND diet, which combines elements of the Mediterranean and DASH diets, might help people with multiple sclerosis (MS) improve brain health and manage symptoms. Participants will either adopt this new diet or continue their usual eating habits for a year. Those with MS who follow a typical diet might be a good fit. Participants will provide blood and stool samples and complete questionnaires and in-person assessments to help researchers gather data. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could enhance dietary recommendations for MS patients.
Do I have to stop taking my current medications for the trial?
The trial does not specify whether you need to stop taking your current medications. It seems focused on diet changes, so you may not need to change your medications, but it's best to confirm with the study team.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that the MIND diet, which combines elements of the Mediterranean and DASH diets, is generally easy to follow. Studies have found that this diet can improve brain health and may help manage symptoms in people with multiple sclerosis (MS).
One study found that adhering to the MIND diet was linked to a lower risk of developing MS. Another study suggested that this diet can help treat MS by reducing inflammation and oxidative stress. These findings indicate the diet is safe for people to follow.
Additionally, the Mediterranean diet, similar to the MIND diet, has proven effective and safe for MS patients, offering benefits without major side effects.
Overall, the MIND diet appears to be a safe choice for those considering dietary changes to help manage MS symptoms.12345Why are researchers excited about this trial?
Unlike the standard treatments for multiple sclerosis, which often include medications like interferons or monoclonal antibodies, the MIND Diet offers a non-pharmacological approach centered on nutrition. The MIND Diet combines elements of the Mediterranean and DASH diets, emphasizing brain-healthy foods like leafy greens, berries, and nuts. Researchers are excited about this dietary approach because it might reduce inflammation and support brain health, potentially slowing disease progression without the side effects associated with conventional drugs. This dietary intervention could empower patients with a manageable lifestyle change that complements existing therapies.
What evidence suggests that the MIND Diet could be effective for multiple sclerosis?
Research suggests that the MIND diet might benefit people with Multiple Sclerosis (MS). One study found that individuals who followed the MIND diet had about a 90% lower chance of developing MS. Another study showed that adherence to the MIND diet improved health scores from low to good in MS patients. Additionally, those who closely followed the MIND diet had larger thalamic volumes, a brain region important for processing information. This trial will evaluate the effects of the MIND diet on MS symptoms, with participants in the intervention arm adhering to the MIND diet for one year. These findings indicate that the MIND diet could support brain health and possibly reduce MS symptoms.13678
Who Is on the Research Team?
Ilana B Katz Sand, MD
Principal Investigator
Icahn School of Medicine at Mount Sinai
Are You a Good Fit for This Trial?
This trial is for individuals with Multiple Sclerosis who are interested in exploring how a specific diet, called the MIND diet, might affect their brain health and MS symptoms. Participants should be willing to either change their eating habits or continue their current diet for one year and provide blood & stool samples along with completing assessments.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants complete baseline assessments including blood and stool samples, online questionnaires, and functional & cognitive assessments
Dietary Intervention
Participants in the intervention arm follow the MIND diet for one year with diet-related education and support, while control arm participants continue their current diet
Follow-up
Participants are monitored for safety and effectiveness after treatment, with assessments at 6 and 12 months
What Are the Treatments Tested in This Trial?
Interventions
- MIND Diet
Trial Overview
The study tests the effects of the MIND Diet on people with MS by comparing two groups: one follows the MIND Diet with support programs, while the other continues their usual diet but receives unrelated MS education. The trial lasts one year and includes online questionnaires and three in-person evaluations.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Participants randomized to the intervention arm will change their dietary patterns to adhere to the MIND diet for one year after randomization.
Participants randomized to the control arm will continue their current dietary habits, without major changes, for one year after randomization. Participants will not receive diet education in small group.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Icahn School of Medicine at Mount Sinai
Lead Sponsor
Citations
MIND Diet Adherence Might be Associated with a Reduced ...
To put it another way, individuals in the third tertile of MIND scores had an estimated 90% lower odds of developing MS, whereas individuals in ...
Evaluation of the Relationship Between Dietary Inflammatory ...
The mean MIND diet score in the MS group (6.3 ± 1.90) was significantly lower (p < 0.05) compared to the control group (6.9 ± 1.71). The mean ...
MIND Diet Impact on Multiple Sclerosis Patients
After the nutritional intervention, adherence to the MIND diet improved significantly, increasing from low (7.61 ± 1.88) to good (12.98 ± 1.22) ...
Investigation of the Effect of the MIND Diet on Disease ...
Adherence to the MIND diet was associated with a reduced risk of MS. ... In a cross-sectional study, the MIND diet compliance score was positively associated with ...
Dietary factors and MRI metrics in early Multiple Sclerosis
MIND diet score was associated with thalamic volume; individuals in the highest quartile of MIND diet scores had greater thalamic volumes versus those in the ...
From prevention to management: Exploring the impact of diet ...
Growing evidence suggests that dietary interventions may influence MS progression and symptom management by modulating inflammation, oxidative stress, and gut ...
Review article Efficacy and safety of the Mediterranean diet ...
The study outcomes suggest that the Mediterranean diet can effectively treat patients with multiple sclerosis, yielding beneficial effects. The ...
Mediterranean and MIND Dietary Patterns and Cognitive ...
Overall, these results suggest that greater alignment with Mediterranean and MIND diets may be associated with better cognitive performance in people living ...
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