Rocaltrol
Hypoparathyroidism, Osteodystrophy, Hemodialysis + 4 more
Treatment
7 Active Studies for Rocaltrol
Treatment for
Hypoparathyroidism
What is Rocaltrol
Calcitriol
The Generic name of this drug
Treatment Summary
Calcitriol is an active form of vitamin D that helps the body maintain proper levels of calcium and phosphate. It is produced naturally in the body when the skin is exposed to sunlight, and is then converted in the kidneys and liver. Calcitriol helps regulate calcium levels in the blood by increasing absorption from the stomach, promoting reabsorption in the kidneys, and stimulating the release of calcium from bones. It is also known to increase energy efficiency, modulate immune and inflammatory responses, and regulate cell turnover and differentiation. Calcitriol is used to treat secondary hyperparathyroidism, hypocalcemia, osteop
Calcitriol
is the brand name
Rocaltrol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Calcitriol
Calcitriol
2001
85
Effectiveness
How Rocaltrol Affects Patients
Calcitriol is a hormone found naturally in the body. It helps regulate calcium metabolism and has been studied for its potential to reduce the risk of certain cancers and autoimmune diseases. Taking calcitriol orally can increase calcium levels in the blood, and a single dose can last up to 5 days. It has also been found to work with other treatments, like dexamethasone, retinoids, and chemotherapy drugs to fight cancer in preclinical studies. It has been studied as a possible treatment for tuberculosis because it can help the body fight off the Mycobacterium tuberculosis bacteria. Lastly, it has both immune-enh
How Rocaltrol works in the body
Calcitriol works to treat psoriasis by reducing the growth of skin cells and stimulating the development of new skin cells. It does this by activating a receptor in the cells called the vitamin D receptor. This receptor turns on or off certain genes, depending on what is bound to it. Calcitriol can also modify how immune cells function, by suppressing a receptor called the aryl hydrocarbon receptor. This stops the production of pro-inflammatory cells and causes monocytes to differentiate more quickly. It also reduces the proliferation and production of cytokines, as well as suppressing immunoglobulin secretion by B lymphocytes.
When to interrupt dosage
The suggested dosage of Rocaltrol is contingent upon the identified affliction, e.g. Plaque Psoriasis, Vitamin D Resistant Rickets and Chronic Kidney Disease. The amount of dosage is also subject to the administration method featured in the table underneath.
Condition
Dosage
Administration
Osteodystrophy
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
Injection, solution, , Injection, solution - Intravenous, Intravenous, Injection, Injection - Intravenous, Capsule, gelatin coated - Oral, Oral, Capsule, gelatin coated, Ointment, Ointment - Topical, Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Solution - Intravenous, Kit
Hemodialysis
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
Injection, solution, , Injection, solution - Intravenous, Intravenous, Injection, Injection - Intravenous, Capsule, gelatin coated - Oral, Oral, Capsule, gelatin coated, Ointment, Ointment - Topical, Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Solution - Intravenous, Kit
Hyperparathyroidism, Secondary
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
Injection, solution, , Injection, solution - Intravenous, Intravenous, Injection, Injection - Intravenous, Capsule, gelatin coated - Oral, Oral, Capsule, gelatin coated, Ointment, Ointment - Topical, Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Solution - Intravenous, Kit
Hypoparathyroidism
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
Injection, solution, , Injection, solution - Intravenous, Intravenous, Injection, Injection - Intravenous, Capsule, gelatin coated - Oral, Oral, Capsule, gelatin coated, Ointment, Ointment - Topical, Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Solution - Intravenous, Kit
Hypocalcemia
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
Injection, solution, , Injection, solution - Intravenous, Intravenous, Injection, Injection - Intravenous, Capsule, gelatin coated - Oral, Oral, Capsule, gelatin coated, Ointment, Ointment - Topical, Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Solution - Intravenous, Kit
Chronic Kidney Disease
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
Injection, solution, , Injection, solution - Intravenous, Intravenous, Injection, Injection - Intravenous, Capsule, gelatin coated - Oral, Oral, Capsule, gelatin coated, Ointment, Ointment - Topical, Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Solution - Intravenous, Kit
Rickets
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
Injection, solution, , Injection, solution - Intravenous, Intravenous, Injection, Injection - Intravenous, Capsule, gelatin coated - Oral, Oral, Capsule, gelatin coated, Ointment, Ointment - Topical, Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Solution - Intravenous, Kit
Warnings
Rocaltrol has two contraindications and ought not to be combined with the conditions listed in the following table.
Rocaltrol Contraindications
Condition
Risk Level
Notes
evidence of vitamin D toxicity
Do Not Combine
Hypercalcemia
Do Not Combine
There are 20 known major drug interactions with Rocaltrol.
Common Rocaltrol Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Calcitriol.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Calcitriol.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Calcitriol.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Calcitriol.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Calcitriol.
Rocaltrol Toxicity & Overdose Risk
The toxic dose of calcitriol for rats is 620 micrograms per kilogram. Symptoms of calcitriol toxicity can include headache, drowsiness, nausea, vomiting, dry mouth, constipation, muscle and bone pain, increased thirst and urination, weight loss, itching, changes in vision, pancreatitis, changes in cholesterol levels, and increased liver enzymes. In rare cases, it can even lead to psychosis.
Rocaltrol Novel Uses: Which Conditions Have a Clinical Trial Featuring Rocaltrol?
30 clinical trials are presently being conducted to analyze the potential of Rocaltrol to ameliorate Hemodialysis, Hypocalcemia and Plaque Psoriasis.
Condition
Clinical Trials
Trial Phases
Osteodystrophy
0 Actively Recruiting
Rickets
2 Actively Recruiting
Early Phase 1, Not Applicable
Chronic Kidney Disease
0 Actively Recruiting
Hyperparathyroidism, Secondary
2 Actively Recruiting
Phase 3, Not Applicable
Hypoparathyroidism
3 Actively Recruiting
Not Applicable, Phase 2, Phase 1
Hemodialysis
0 Actively Recruiting
Hypocalcemia
0 Actively Recruiting
Rocaltrol Reviews: What are patients saying about Rocaltrol?
5
Patient Review
12/4/2008
Rocaltrol for Condition caused by Low Levels of Parathyroid Hormone
5
Patient Review
2/17/2009
Rocaltrol for Vitamin D Deficiency
5
Patient Review
6/12/2013
Rocaltrol for Condition caused by Low Levels of Parathyroid Hormone
4.7
Patient Review
1/19/2009
Rocaltrol for Vitamin D Deficiency
4
Patient Review
8/1/2011
Rocaltrol for Hyperparathyroidism caused by Chronic Kidney Failure
4
Patient Review
7/16/2009
Rocaltrol for Condition caused by Low Levels of Parathyroid Hormone
3.7
Patient Review
9/9/2009
Rocaltrol for Hyperparathyroidism caused by Chronic Kidney Failure
3
Patient Review
3/15/2010
Rocaltrol for Osteoporosis
Patient Q&A Section about rocaltrol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is calcitriol and Rocaltrol the same?
"Calcitriol is a strong form of vitamin d that raises calcium levels. It is most commonly used in people who have kidney or parathyroid problems."
Answered by AI
What are the common side effects of Rocaltrol?
"new or worsening mouth sores,, muscle aches,, upset stomach,, skin problems, including itching
The text describes symptoms which may be caused by kidney failure, including increased thirst, urinating more than usual, changes in heart rate, headache, drowsiness, changes in behavior, bone pain, mouth sores, muscle aches, upset stomach, and skin problems."
Answered by AI
What is Rocaltrol used for?
"Rocaltrol is used to treat calcium deficiency, decreased functioning of the parathyroid glands, and metabolic bone disease in people with chronic kidney failure."
Answered by AI
Is calcitriol the same as vitamin D?
"The most active form of vitamin d, calcitriol, has a very short half-life of a few hours. Although originally it was thought that calcitriol was only produced in the kidney, it is now known to be produced in many other tissues as well."
Answered by AI