Rocaltrol

Hypoparathyroidism, Osteodystrophy, Hemodialysis + 4 more
Treatment
15 Active Studies for Rocaltrol

What is Rocaltrol

CalcitriolThe Generic name of this drug
Treatment SummaryCalcitriol is an active form of vitamin D that helps the body maintain proper levels of calcium and phosphate. It is produced naturally in the body when the skin is exposed to sunlight, and is then converted in the kidneys and liver. Calcitriol helps regulate calcium levels in the blood by increasing absorption from the stomach, promoting reabsorption in the kidneys, and stimulating the release of calcium from bones. It is also known to increase energy efficiency, modulate immune and inflammatory responses, and regulate cell turnover and differentiation. Calcitriol is used to treat secondary hyperparathyroidism, hypocalcemia, osteop
Calcitriolis the brand name
Rocaltrol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Calcitriol
Calcitriol
2001
85

Effectiveness

How Rocaltrol Affects PatientsCalcitriol is a hormone found naturally in the body. It helps regulate calcium metabolism and has been studied for its potential to reduce the risk of certain cancers and autoimmune diseases. Taking calcitriol orally can increase calcium levels in the blood, and a single dose can last up to 5 days. It has also been found to work with other treatments, like dexamethasone, retinoids, and chemotherapy drugs to fight cancer in preclinical studies. It has been studied as a possible treatment for tuberculosis because it can help the body fight off the Mycobacterium tuberculosis bacteria. Lastly, it has both immune-enh
How Rocaltrol works in the bodyCalcitriol works to treat psoriasis by reducing the growth of skin cells and stimulating the development of new skin cells. It does this by activating a receptor in the cells called the vitamin D receptor. This receptor turns on or off certain genes, depending on what is bound to it. Calcitriol can also modify how immune cells function, by suppressing a receptor called the aryl hydrocarbon receptor. This stops the production of pro-inflammatory cells and causes monocytes to differentiate more quickly. It also reduces the proliferation and production of cytokines, as well as suppressing immunoglobulin secretion by B lymphocytes.

When to interrupt dosage

The suggested dosage of Rocaltrol is contingent upon the identified affliction, e.g. Plaque Psoriasis, Vitamin D Resistant Rickets and Chronic Kidney Disease. The amount of dosage is also subject to the administration method featured in the table underneath.
Condition
Dosage
Administration
Hemodialysis
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Solution - Intravenous, Kit
Vitamin D Resistant Rickets
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Solution - Intravenous, Kit
Hyperparathyroidism, Secondary
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Solution - Intravenous, Kit
Chronic Kidney Disease
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Solution - Intravenous, Kit
Hypoparathyroidism
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Solution - Intravenous, Kit
Hypocalcemia
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Solution - Intravenous, Kit
Osteodystrophy
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Solution - Intravenous, Kit

Warnings

Rocaltrol has two contraindications and ought not to be combined with the conditions listed in the following table.Rocaltrol Contraindications
Condition
Risk Level
Notes
evidence of vitamin D toxicity
Do Not Combine
Hypercalcemia
Do Not Combine
There are 20 known major drug interactions with Rocaltrol.
Common Rocaltrol Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Calcitriol.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Calcitriol.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Calcitriol.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Calcitriol.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Calcitriol.
Rocaltrol Toxicity & Overdose RiskThe toxic dose of calcitriol for rats is 620 micrograms per kilogram. Symptoms of calcitriol toxicity can include headache, drowsiness, nausea, vomiting, dry mouth, constipation, muscle and bone pain, increased thirst and urination, weight loss, itching, changes in vision, pancreatitis, changes in cholesterol levels, and increased liver enzymes. In rare cases, it can even lead to psychosis.

Rocaltrol Novel Uses: Which Conditions Have a Clinical Trial Featuring Rocaltrol?

30 clinical trials are presently being conducted to analyze the potential of Rocaltrol to ameliorate Hemodialysis, Hypocalcemia and Plaque Psoriasis.
Condition
Clinical Trials
Trial Phases
Chronic Kidney Disease
1 Actively Recruiting
Phase 3
Hemodialysis
0 Actively Recruiting
Hyperparathyroidism, Secondary
5 Actively Recruiting
Phase 3
Vitamin D Resistant Rickets
0 Actively Recruiting
Osteodystrophy
0 Actively Recruiting
Hypocalcemia
1 Actively Recruiting
Phase 3
Hypoparathyroidism
8 Actively Recruiting
Not Applicable, Phase 2, Phase 3

Rocaltrol Reviews: What are patients saying about Rocaltrol?

5Patient Review
12/4/2008
Rocaltrol for Condition caused by Low Levels of Parathyroid Hormone
For almost 20 years, I've been struggling with hypoparathyroidism. Rocaltrol has quite literally saved my life and I'm so grateful that there's now a generic version available to help cut costs. Every six months, I get bloodwork done and meet with my endocrinologist to see if my dosage needs to be adjusted--but this drug is nothing short of a miracle.
5Patient Review
2/17/2009
Rocaltrol for Vitamin D Deficiency
Since having my thyroid removed (due to cancer), this medication has been essential. It's kept me from going into muscle spasms and overall feeling numb. Can't imagine life without it at this point!
5Patient Review
6/12/2013
Rocaltrol for Condition caused by Low Levels of Parathyroid Hormone
I have been taking rocaltral for 10 years to treat hypoparathyroidism. I have to take potassium and calcium pills along with it, and I've been hospitalized once or twice a year due to high or low calcium levels. Now my doctor wants me to try teriparatide injections, which are very expensive (over $1000 per month). I'm not sure if I want to try this new treatment or not.
4.7Patient Review
1/19/2009
Rocaltrol for Vitamin D Deficiency
I am so grateful that this medication was available when I needed it. It saved my life and allowed me to live a normal life for 35 years. I'm even more thankful that I was able to find an alternative and get off the medication.
4Patient Review
8/1/2011
Rocaltrol for Hyperparathyroidism caused by Chronic Kidney Failure
The diarrhea was a bit of an issue for me, but I understand that it's a common side effect. This medication also lowered my parathyroid hormone from 94 to 72, and increased my vitamin D levels to 40.
4Patient Review
7/16/2009
Rocaltrol for Condition caused by Low Levels of Parathyroid Hormone
This treatment has been a life saver for me! I'm 9 months post-op from a complete thyroidectomy/parathyroidectomy tumor removal. My three remaining parathyroid glands are dormant, so I lack PTH (parathyroid hormone). Without PTH, you can't absorb calcium. Calcitriol is a synthetic form of vitamin D that helps with calcium absorption, and it's been working great for me.
3.7Patient Review
9/9/2009
Rocaltrol for Hyperparathyroidism caused by Chronic Kidney Failure
My hemoglobin levels increased significantly after taking this medication.
3Patient Review
3/15/2010
Rocaltrol for Osteoporosis
This treatment is great. I love how it helps me feel better.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about rocaltrol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is calcitriol and Rocaltrol the same?

"Calcitriol is a strong form of vitamin d that raises calcium levels. It is most commonly used in people who have kidney or parathyroid problems."

Answered by AI

What are the common side effects of Rocaltrol?

"new or worsening mouth sores,, muscle aches,, upset stomach,, skin problems, including itching

The text describes symptoms which may be caused by kidney failure, including increased thirst, urinating more than usual, changes in heart rate, headache, drowsiness, changes in behavior, bone pain, mouth sores, muscle aches, upset stomach, and skin problems."

Answered by AI

What is Rocaltrol used for?

"Rocaltrol is used to treat calcium deficiency, decreased functioning of the parathyroid glands, and metabolic bone disease in people with chronic kidney failure."

Answered by AI

Is calcitriol the same as vitamin D?

"The most active form of vitamin d, calcitriol, has a very short half-life of a few hours. Although originally it was thought that calcitriol was only produced in the kidney, it is now known to be produced in many other tissues as well."

Answered by AI

Clinical Trials for Rocaltrol

Have you considered Rocaltrol clinical trials? We made a collection of clinical trials featuring Rocaltrol, we think they might fit your search criteria.
Have you considered Rocaltrol clinical trials? We made a collection of clinical trials featuring Rocaltrol, we think they might fit your search criteria.
Have you considered Rocaltrol clinical trials? We made a collection of clinical trials featuring Rocaltrol, we think they might fit your search criteria.