Reviewed by Michael Gill, B. Sc.
Image of Weill Cornell Medical College in New York, United States.
Phase-Based Progress Estimates
3
Effectiveness
3
Safety

Vitamin Dfor Obesity

< 65
All Sexes
The discovery that the vitamin D receptor is expressed in more than 30 tissues indicates that the physiologic functions of vitamin D are much broader than its well-known role in the regulation of calcium absorption and bone metabolism. There is evidence that vitamin D is involved in the pathogenesis of cancer, cardiovascular disease, multiple sclerosis, and type I diabetes. Recent epidemiological evidence points to a strong association between vitamin D insufficiency and insulin resistance, the metabolic syndrome, and type II diabetes. The investigators would like to examine the role of vitamin D in the development of insulin resistance in overweight children and adolescents, which represent a high risk population for cardiovascular and metabolic complications. The investigators propose a prospective randomized clinical trial of vitamin D supplementation in overweight, insulin resistant, vitamin D deficient children. The investigators objective is to assess if changes in insulin resistance, fasting lipid profiles, blood pressure, and inflammatory markers occur in these patients post treatment with vitamin D. Additionally, concomitant changes in calcium and bone metabolism after vitamin D treatment will be evaluated. This is because, contrary to adults, the optimal vitamin D concentrations that regulate calcium and bone metabolism have not been established in pediatrics.
Phase 4
Waitlist Available
Weill Cornell Medical CollegeMaria Vogiatzi, MD
25 Vitamin D Clinical Trials Near Me
Vitamin D Clinical Trials by Phase of Trial
Phase < 1 Vitamin D Clinical Trials
7Active Vitamin D Clinical Trials
5Number of Unique Treatments
6Number of Active Locations
Vitamin D3Vitamin D3Vitamin D + L-cysteineVitamin D3Vitamin DcholecalciferolCholecalciferol
Most Recent Vitamin D Clinical Trials

What Are Vitamin D Clinical Trials?

Vitamin D clinical trials are studies conducted to see how Vitamin D can help people with certain medical conditions. Currently, Vitamin D is used to treat conditions such as osteoporosis, multiple sclerosis, and cancer.

Vitamin D clinical trials are necessary because they help scientists learn more about how Vitamin D works in the body and what possible side effects there may be. Vitamin D clinical trials are also necessary because they help scientists determine whether Vitamin D is effective in treating specific medical conditions.

Why Is Vitamin D Being Studied in Clinical Trials?

Vitamin D has already been known to help absorb calcium and phosphorus and maintain healthy bones and teeth. Vitamin D is also thought to have other potential health benefits, such as reducing the risk of developing certain types of cancer, heart disease, and diabetes.

Recent clinical trials are studying Vitamin D to see if it's effective supplementation for early treatment of COVID-19. Another study was conducted to see if Vitamin D deficiency was associated with the risk of Type 1 Diabetes. However, the study concluded that it did not significantly affect the risk.

Other recent clinical trials over the past few years are testing to see the effects of Vitamin D on muscle status in old patients recovering from COVID-19, the prevention of cancer and other Cardiovascular diseases, and insulin resistance in PCOS patients.

How Does Vitamin D Work?

Vitamin D is a nutrient found in some foods and can also be made by your body when your skin is exposed to sunlight. It also can be absorbed from over-the-counter supplements. Lastly, it can be absorbed through manufactured light bulbs that emit Vitamin D.

Vitamin D works by helping your body absorb calcium and phosphorus. These minerals are essential for maintaining healthy bones and teeth. Vitamin D also helps to keep your immune system strong and may help to reduce the risk of developing some types of cancer, heart disease, and diabetes.

More than a billion people worldwide are Vitamin D deficient, a healthcare issue that needs tackling. Hence, clinical trials involving Vitamin D are essential as they can help improve many people's health.

What Are Some of The Breakthrough Clinical Trials Involving Vitamin D?

There are many breakthrough clinical trials involving the testing of Vitamin D. Here are some of the recent major studies currently being conducted or that have been conducted in the past few years:

2018: This study found that a high dose of approximately 50,000 IU a week can improve the symptoms of PMS and dysmenorrhea in premenstrual syndrome in adolescents.

2019: Another study found that daily high-dose vitamin D supplementation significantly helped bone density and strength.

2020: One of the most recent studies is testing Vitamin D as a supplement against the risk of COVID-19. Currently, it is in Phase III of testing and is not recruiting more members.

Who Are The Key Opinion Leaders On Vitamin D Clinical Trial Research?

Michael F. Holick, MD, Ph.D.: He is a Vitamin D expert and professor of medicine, physiology, and biophysics at Boston University School of Medicine.

Bess Dawson-Hughes, MD: She is a Vitamin D and calcium researcher and director of the Bone Metabolism Laboratory at the USDA Human Nutrition Research Center on Aging at Tufts University.

Cedric Garland, DrPH: An epidemiologist and Vitamin D researcher who has studied Vitamin D for over 40 years.

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 30th, 2021

Last Reviewed: November 25th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

References1 Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189-98. https://pubmed.ncbi.nlm.nih.gov/12022042 Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56. https://pubmed.ncbi.nlm.nih.gov/112531563 Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994 Mar;49(2):M85-94. https://pubmed.ncbi.nlm.nih.gov/81263564 Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mailhe M, Doudier B, Courjon J, Giordanengo V, Vieira VE, Tissot Dupont H, Honoré S, Colson P, Chabrière E, La Scola B, Rolain JM, Brouqui P, Raoult D. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020 Jul;56(1):105949. doi: 10.1016/j.ijantimicag.2020.105949. Epub 2020 Mar 20. https://pubmed.ncbi.nlm.nih.gov/322052045 Holick MF. Vitamin D deficiency. N Engl J Med. 2007 Jul 19;357(3):266-81. Review. https://pubmed.ncbi.nlm.nih.gov/176344626 Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM; Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385. Epub 2011 Jun 6. Erratum in: J Clin Endocrinol Metab. 2011 Dec;96(12):3908. https://pubmed.ncbi.nlm.nih.gov/216463687 Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, Nieman DC, Swain DP; American College of Sports Medicine. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011 Jul;43(7):1334-59. doi: 10.1249/MSS.0b013e318213fefb. https://pubmed.ncbi.nlm.nih.gov/216945568 Holick MF. Vitamin D deficiency. N Engl J Med. 2007 Jul 19;357(3):266-81. doi: 10.1056/NEJMra070553. No abstract available. https://pubmed.ncbi.nlm.nih.gov/176344629 Gao J, Tian Z, Yang X. Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Biosci Trends. 2020 Mar 16;14(1):72-73. doi: 10.5582/bst.2020.01047. Epub 2020 Feb 19. https://pubmed.ncbi.nlm.nih.gov/3207455010 Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011 Jan;96(1):53-8. doi: 10.1210/jc.2010-2704. Epub 2010 Nov 29. https://pubmed.ncbi.nlm.nih.gov/21118827