Omega-3 + Vitamin D for High Blood Pressure
What You Need to Know Before You Apply
What is the purpose of this trial?
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is an ongoing randomized clinical trial in 25,875 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids (Omacor® fish oil, 1 gram) reduces the risk of developing cancer, heart disease, and stroke in people who do not have a prior history of these illnesses. The VITAL Hypertension ancillary study is being conducted among participants in VITAL and will examine whether vitamin D or omega-3 fatty acids are related to changes in blood pressure and hypertension.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is it safe to take omega-3 and vitamin D supplements for high blood pressure?
Omega-3 supplements, like fish oil, are generally safe for most people, but they can cause side effects like nausea, diarrhea, and a 'fishy' taste. They may also increase bleeding times and affect platelet levels, so it's important to use them carefully. Vitamin D supplements are usually safe at recommended doses, but taking too much can lead to health issues.12345
How is the Omega-3 and Vitamin D treatment for high blood pressure different from other treatments?
This treatment is unique because it combines Omega-3 fatty acids, which have shown potential in lowering blood pressure, with Vitamin D, which is not commonly used for this purpose. The combination of these two supplements may offer a novel approach to managing high blood pressure compared to traditional medications.16789
What data supports the effectiveness of the treatment Omega-3 fatty acids (fish oil) and Vitamin D-3 for high blood pressure?
Who Is on the Research Team?
Howard D. Sesso, ScD, MPH
Principal Investigator
Brigham and Women's Hospital
John P. Forman, MD
Principal Investigator
Brigham and Women's Hospital
Are You a Good Fit for This Trial?
The VITAL Hypertension trial is for U.S. adults without a history of high blood pressure, cancer, heart disease, or stroke who are already part of the main VITAL study. It's focused on those willing to take daily supplements and located in certain cities where home visits can be conducted.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants undergo baseline assessments including 24-hour ABP measurements, fasting bloods, and spot urine samples
Treatment
Participants receive daily dietary supplements of vitamin D3 or omega-3 fatty acids or placebo
Follow-up
Participants are monitored for changes in blood pressure and new diagnoses of hypertension
What Are the Treatments Tested in This Trial?
Interventions
- Omega-3 fatty acids (fish oil)
- Vitamin D-3 (cholecalciferol), 2000 IU
Find a Clinic Near You
Who Is Running the Clinical Trial?
Brigham and Women's Hospital
Lead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator