Entresto

Hypesthesia, Hypesthesia, Hypesthesia + 15 more
Treatment
11 FDA approvals
20 Active Studies for Entresto

What is Entresto

ValsartanThe Generic name of this drug
Treatment SummarySacubitril is a medication used in combination with valsartan to reduce the risk of cardiovascular events in people with chronic heart failure and reduced ejection fraction. It was approved by the FDA in 2015. Sacubitril works by blocking an enzyme called neprilysin that usually breaks down certain proteins like atrial natriuretic peptide, brain natriuretic peptide, and c-type natriuretic peptide. These proteins are released when the heart is under stress and cause vasodilation, natriuresis and diuresis. Blocking neprilysin also increases levels of hormones
Diovanis the brand name
image of different drug pills on a surface
Entresto Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Diovan
Valsartan
1996
621

Approved as Treatment by the FDA

Valsartan, also known as Diovan, is approved by the FDA for 11 uses such as Heart failure and High Blood Pressure .
Heart failure
Used to treat Heart Failure in combination with Sacubitril
High Blood Pressure
Used to treat Moderate Essential Hypertension in combination with Hydrochlorothiazide
chronic heart failure with reduced ejection fraction (NYHA Class II-IV)
Used to treat chronic heart failure with reduced ejection fraction (NYHA Class II-IV) in combination with Sacubitril
Heart Failure
Used to treat hospitalization due to cardiac failure in combination with Sacubitril
Systolic Left Ventricular Dysfunction
Used to treat Systolic Left Ventricular Dysfunction in combination with Sacubitril
Moderate Essential Hypertension
Used to treat Moderate Essential Hypertension in combination with Hydrochlorothiazide
Combined Modality Therapy
Used to treat patients for whom combination therapy is appropriate in combination with Hydrochlorothiazide
Cardiovascular Mortality
Used to treat Cardiovascular Mortality in combination with Sacubitril
Hypesthesia
Used to treat chronic heart failure with reduced ejection fraction (NYHA Class II-IV) in combination with Sacubitril
Congestive Heart Failure
Used to treat Heart Failure in combination with Sacubitril
Ventricular Dysfunction, Left
Used to treat Systolic Left Ventricular Dysfunction in combination with Sacubitril

Effectiveness

How Entresto Affects PatientsIn studies with people who had a reduced heart ejection fraction, taking the drug Entresto (sacubitril + valsartan) increased the amount of salt and other substances (natriuresis, cGMP) in the urine, and decreased certain proteins (MR-proANP, NT-proBNP, aldosterone, and endothelin-1) in the blood. It did not affect the QTc interval.
How Entresto works in the bodySacubitril works by blocking an enzyme called neprilysin. This enzyme normally breaks down naturally-occurring peptides that cause vasodilation and decreased blood pressure. When the enzyme is blocked, there are higher levels of these peptides, which results in reduced vascular resistance and lower blood pressure. When taken with valsartan, sacubitril also blocks the effects of a hormone that typically increases blood pressure. The combined effects of these two drugs leads to a decrease in blood pressure.

When to interrupt dosage

The measure of Entresto is contingent upon the identified condition, for instance Hypesthesia, prophylaxis of cardiovascular event and Cardiovascular Events. The amount likewise changes according to the process of delivery (e.g. Tablet or Tablet, film coated) featured in the table beneath.
Condition
Dosage
Administration
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Diabetic Nephropathies
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Congestive Heart Failure
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Type 2 Diabetes
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
High Blood Pressure
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Cardiovascular Mortality
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypertensive disease
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Combined Modality Therapy
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
initial treatment
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
multiple antihypertensive drugs likely required
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
not adequately controlled with monotherapy
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Ventricular Dysfunction, Left
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Left Ventricular Failure, Unspecified
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Ventricular Dysfunction, Left
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Heart Failure
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral

Warnings

Entresto Contraindications
Condition
Risk Level
Notes
Type 2 Diabetes
Do Not Combine
Breast Milk Production
Do Not Combine
Diabetes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Valsartan may interact with Pulse Frequency
There are 20 known major drug interactions with Entresto.
Common Entresto Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Valsartan.
Amifostine
Major
Valsartan may increase the hypotensive activities of Amifostine.
Cabozantinib
Major
The metabolism of Cabozantinib can be decreased when combined with Valsartan.
Capecitabine
Major
The metabolism of Capecitabine can be decreased when combined with Valsartan.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Valsartan.
Entresto Toxicity & Overdose RiskCommon side effects of overdosing on enalapril include low blood pressure, high potassium levels, coughing, dizziness, and kidney failure.
image of a doctor in a lab doing drug, clinical research

Entresto Novel Uses: Which Conditions Have a Clinical Trial Featuring Entresto?

19 active studies are currently being conducted to assess the capacity of Entresto for the prophylaxis of Cardiovascular Events, Hypesthesia and other Cardiovascular-related Issues.
Condition
Clinical Trials
Trial Phases
Hypesthesia
7 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1
Diabetic Nephropathies
0 Actively Recruiting
Ventricular Dysfunction, Left
1 Actively Recruiting
Phase 2, Phase 3
Type 2 Diabetes
174 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
High Blood Pressure
4 Actively Recruiting
Not Applicable, Early Phase 1
Congestive Heart Failure
173 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Hypesthesia
2 Actively Recruiting
Not Applicable
Cardiovascular Mortality
0 Actively Recruiting
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Ventricular Dysfunction, Left
0 Actively Recruiting
Combined Modality Therapy
0 Actively Recruiting
Heart Failure
0 Actively Recruiting
Left Ventricular Failure, Unspecified
0 Actively Recruiting
Hypesthesia
0 Actively Recruiting
not adequately controlled with monotherapy
0 Actively Recruiting
Hypesthesia
10 Actively Recruiting
Not Applicable, Phase 1
initial treatment
0 Actively Recruiting
multiple antihypertensive drugs likely required
0 Actively Recruiting

Entresto Reviews: What are patients saying about Entresto?

5Patient Review
10/2/2021
Entresto for Chronic Heart Failure
Entresto has been an incredible medication for me. After only six months, my heart enlargement is gone and mitral regurgitation has decreased significantly. My ejection phase is now up to 50%! I was told last year that I had 1-3 years left to live, but after taking Entresto my prognosis is much more optimistic.
5Patient Review
4/5/2019
Entresto for Chronic Heart Failure
I was really struggling before I started taking this medication. I could hardly do anything without being out of breath and feeling weak. Walking to the bathroom would leave me trembling. But, I'm so glad I decided to try it anyway. The reviews were mixed, but I saw an improvement in just the first week.
5Patient Review
7/7/2021
Entresto for Chronic Heart Failure
I experienced a huge increase in my white blood cell count after starting this treatment, and it's been much less intrusive than chemotherapy.
5Patient Review
12/27/2020
Entresto for Chronic Heart Failure
I'm a 69-year-old male in relatively good shape. I started taking Entreto 3 months ago and have only experienced dizziness when standing up quickly. My blood pressure is 110/76, resting heart rate in low 40s, Oxygen saturation >95%. So far I feel great and haven't noticed any negative effects.
5Patient Review
9/30/2021
Entresto for Chronic Heart Failure
Entresto is, without a doubt, the best heart failure medication available. I was hospitalized two years ago and could barely breathe; walking up stairs was impossible. My cardiologist prescribed Entresto while I was in the hospital, and I recovered rapidly--literally overnight! I've been taking it ever since with no issues whatsoever. Please don't stop making this incredible drug!
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about entresto

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Entresto medication used for?

"This product, which contains sacubitril and valsartan, is used to treat certain types of heart failure. It may help the patient live longer and lower the chance of having to go to the hospital for heart failure."

Answered by AI

Is Entresto a high blood pressure medication?

"Entresto is a drug used to lower blood pressure. The most common side effects are low blood pressure, coughing, and dizziness."

Answered by AI

Does Entresto have a diuretic in it?

"Entresto does not contain a beta-blocker or a diuretic. It is a combination of two drugs, sacubitril and valsartan. Sacubitril is a neprilysin inhibitor while valsartan is an angiotensin II receptor blocker."

Answered by AI

What are some side effects of Entresto?

"A light-headed feeling, like you might pass out, extreme tiredness, or high potassium might mean slow heart rate, weak pulse, muscle weakness, and a tingly feeling. Kidney problems, such as little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath, might also be a symptom."

Answered by AI

Why is Entresto used for heart failure?

"Entresto is a medication used to lower the risk of cardiovascular death and hospitalization for heart failure in patients with heart failure and reduced ejection fraction. Entresto relaxes blood vessels, improves blood flow, and reduces stress on the heart."

Answered by AI

What are the side effects for Entresto?

"Some side effects of Entresto include feeling light-headed or like you might pass out, extreme tiredness, high potassium levels (which can cause slow heart rate, weak pulse, muscle weakness, or a tingly feeling), or kidney problems (including little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath)."

Answered by AI

Clinical Trials for Entresto

Have you considered Entresto clinical trials? We made a collection of clinical trials featuring Entresto, we think they might fit your search criteria.
Have you considered Entresto clinical trials? We made a collection of clinical trials featuring Entresto, we think they might fit your search criteria.
Have you considered Entresto clinical trials? We made a collection of clinical trials featuring Entresto, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top