What is Entresto
SacubitrilThe Generic name of this drug
Treatment SummarySacubitril is a medication used in combination with valsartan to reduce the risk of cardiovascular events in people with chronic heart failure and reduced ejection fraction. It was approved by the FDA in 2015. Sacubitril works by blocking an enzyme called neprilysin that usually breaks down certain proteins like atrial natriuretic peptide, brain natriuretic peptide, and c-type natriuretic peptide. These proteins are released when the heart is under stress and cause vasodilation, natriuresis and diuresis. Blocking neprilysin also increases levels of hormones
Entrestois the brand name
Entresto Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Entresto
Sacubitril
2015
5
Approved as Treatment by the FDA
Sacubitril, also called Entresto, is approved by the FDA for 5 uses including Cardiovascular Mortality and Ventricular Dysfunction, Left .Cardiovascular Mortality
Used to treat Cardiovascular Mortality in combination with Valsartan
Ventricular Dysfunction, Left
Used to treat Systolic Left Ventricular Dysfunction in combination with Valsartan
Congestive Heart Failure
Used to treat Heart Failure in combination with Valsartan
Hypesthesia
Used to treat chronic heart failure with reduced ejection fraction (NYHA Class II-IV) in combination with Valsartan
hospitalization due to cardiac failure
Used to treat hospitalization due to cardiac failure in combination with Valsartan
Effectiveness
How Entresto Affects PatientsIn studies with people who had a reduced heart ejection fraction, taking the drug Entresto (sacubitril + valsartan) increased the amount of salt and other substances (natriuresis, cGMP) in the urine, and decreased certain proteins (MR-proANP, NT-proBNP, aldosterone, and endothelin-1) in the blood. It did not affect the QTc interval.
How Entresto works in the bodySacubitril works by blocking an enzyme called neprilysin. This enzyme normally breaks down naturally-occurring peptides that cause vasodilation and decreased blood pressure. When the enzyme is blocked, there are higher levels of these peptides, which results in reduced vascular resistance and lower blood pressure. When taken with valsartan, sacubitril also blocks the effects of a hormone that typically increases blood pressure. The combined effects of these two drugs leads to a decrease in blood pressure.
When to interrupt dosage
The measure of Entresto is contingent upon the identified condition, for instance Hypesthesia, prophylaxis of cardiovascular event and Cardiovascular Events. The amount likewise changes according to the process of delivery (e.g. Tablet or Tablet, film coated) featured in the table beneath.Condition
Dosage
Administration
Hypesthesia
24.0 mg, 49.0 mg, , 97.0 mg
Tablet, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet - Oral,
Hypesthesia
24.0 mg, 49.0 mg, , 97.0 mg
Tablet, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet - Oral,
Cardiovascular Events
24.0 mg, 49.0 mg, , 97.0 mg
Tablet, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet - Oral,
Hypesthesia
24.0 mg, 49.0 mg, , 97.0 mg
Tablet, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet - Oral,
prophylaxis of cardiovascular event
24.0 mg, 49.0 mg, , 97.0 mg
Tablet, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet - Oral,
Warnings
There are 20 known major drug interactions with Entresto.Common Entresto Drug Interactions
Drug Name
Risk Level
Description
Revefenacin
Major
Sacubitril may decrease the excretion rate of Revefenacin which could result in a higher serum level.
Vazegepant
Major
The serum concentration of Zavegepant can be increased when it is combined with Sacubitril.
Acrivastine
Minor
Sacubitril may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Sacubitril may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Almasilate
Minor
Sacubitril may decrease the excretion rate of Almasilate which could result in a higher serum level.
Entresto Toxicity & Overdose RiskCommon side effects of overdosing on enalapril include low blood pressure, high potassium levels, coughing, dizziness, and kidney failure.
Entresto Novel Uses: Which Conditions Have a Clinical Trial Featuring Entresto?
19 active studies are currently being conducted to assess the capacity of Entresto for the prophylaxis of Cardiovascular Events, Hypesthesia and other Cardiovascular-related Issues.Condition
Clinical Trials
Trial Phases
Hypesthesia
7 Actively Recruiting
Not Applicable, Phase 1, Phase 2
prophylaxis of cardiovascular event
0 Actively Recruiting
Hypesthesia
5 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1, Phase 2
Cardiovascular Events
5 Actively Recruiting
Not Applicable
Hypesthesia
4 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Entresto Reviews: What are patients saying about Entresto?
5Patient Review
10/2/2021 Entresto has been an incredible medication for me. After only six months, my heart enlargement is gone and mitral regurgitation has decreased significantly. My ejection phase is now up to 50%! I was told last year that I had 1-3 years left to live, but after taking Entresto my prognosis is much more optimistic.
5Patient Review
4/5/2019 I was really struggling before I started taking this medication. I could hardly do anything without being out of breath and feeling weak. Walking to the bathroom would leave me trembling. But, I'm so glad I decided to try it anyway. The reviews were mixed, but I saw an improvement in just the first week.
5Patient Review
7/7/2021 I experienced a huge increase in my white blood cell count after starting this treatment, and it's been much less intrusive than chemotherapy.
5Patient Review
12/27/2020 I'm a 69-year-old male in relatively good shape. I started taking Entreto 3 months ago and have only experienced dizziness when standing up quickly. My blood pressure is 110/76, resting heart rate in low 40s, Oxygen saturation >95%. So far I feel great and haven't noticed any negative effects.
5Patient Review
9/30/2021 Entresto is, without a doubt, the best heart failure medication available. I was hospitalized two years ago and could barely breathe; walking up stairs was impossible. My cardiologist prescribed Entresto while I was in the hospital, and I recovered rapidly--literally overnight! I've been taking it ever since with no issues whatsoever. Please don't stop making this incredible drug!
5Patient Review
4/4/2022 I've been on Entresto for about a year and my ejection fraction has increased from 45% to 55%. My heart condition has overall improved thanks to this medication, according to my doctors.
5Patient Review
1/13/2022 I'm so thankful for Entresto! In just 4 months it's helped my heart go from 20% capacity to 40%.
4Patient Review
12/11/2018 I was struggling with fatigue and shortness of breath after my quadruple bypass, but entresto has really helped me out. The swelling around my knees and ankles went down almost immediately, and I'm now able to sleep lying flat again. I'm feeling like a new man--tonight I'm going dancing!
4Patient Review
5/28/2022 I had recently discovered that I had atrial fibrillation and was put on Elquis and Metoprolol by my doctor. I was also referred to a cardiologist who put me on Entresto after finding out my ejection fraction was only 25-30%. I underwent cardioversion to get out of the a-fib, and then one month later (35 days) had another echocardiogram which showed my ejection fraction was now 45-50%. It's hard to say whether it was Elquis, Metoprolol, Entresto, or some combination thereof that helped me improve so
2.3Patient Review
8/21/2021 I've only been on this medication for five days, and I've had headaches every day. The fifth day was especially bad - I felt dizzy all day and like I was going to pass out. Additionally, I experienced numbness in my hands and tongue. This has all made it very hard to function normally.
2Patient Review
12/19/2021 My husband was put on entresto by a cardiologist. However, after only two weeks the doctors took him off the medication because his kidneys weren't functioning well. A week later, the cardiologist told him to go back on it as he needed it to have valve replacement. Unfortunately, he went downhill on day 2 and died on day 5.
1.3Patient Review
2/25/2021 I started taking this drug 8 days ago and I have experienced severe abdominal or stomach pain, numbness or tingling in the hands, nausea and a cough. Today I'm seeing my primary doctor to see what he can do to stop my having this severe abdominal pain.
1Patient Review
4/18/2022 I originally posted on 4/9/22 about my husband's worsening condition since taking Entresto. Unfortunately, he died of vfib the next morning. Entresto is dangerous.
Patient Q&A Section about entresto
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Entresto medication used for?
"This product, which contains sacubitril and valsartan, is used to treat certain types of heart failure. It may help the patient live longer and lower the chance of having to go to the hospital for heart failure."
Answered by AI
Is Entresto a high blood pressure medication?
"Entresto is a drug used to lower blood pressure. The most common side effects are low blood pressure, coughing, and dizziness."
Answered by AI
Does Entresto have a diuretic in it?
"Entresto does not contain a beta-blocker or a diuretic. It is a combination of two drugs, sacubitril and valsartan. Sacubitril is a neprilysin inhibitor while valsartan is an angiotensin II receptor blocker."
Answered by AI
What are some side effects of Entresto?
"A light-headed feeling, like you might pass out, extreme tiredness, or high potassium might mean slow heart rate, weak pulse, muscle weakness, and a tingly feeling. Kidney problems, such as little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath, might also be a symptom."
Answered by AI
Why is Entresto used for heart failure?
"Entresto is a medication used to lower the risk of cardiovascular death and hospitalization for heart failure in patients with heart failure and reduced ejection fraction. Entresto relaxes blood vessels, improves blood flow, and reduces stress on the heart."
Answered by AI
What are the side effects for Entresto?
"Some side effects of Entresto include feeling light-headed or like you might pass out, extreme tiredness, high potassium levels (which can cause slow heart rate, weak pulse, muscle weakness, or a tingly feeling), or kidney problems (including little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath)."
Answered by AI