Rapamune

corticosteroid therapy, Kidney Transplant, Lymphangioleiomyomatosis + 5 more
Treatment
3 FDA approvals
20 Active Studies for Rapamune

What is Rapamune

SirolimusThe Generic name of this drug
Treatment SummarySirolimus, also known as rapamycin, is a medication derived from bacteria found in the soil of Easter Island. It is used to suppress the immune system and treat tumors. It works by targeting and blocking the mammalian target of rapamycin (mTOR), a protein that regulates cell growth, proliferation and survival. This drug was approved by the FDA in 1999 for kidney transplants and in 2015 for lymphangioleiomyomatosis. In 2021, it was approved for the treatment of malignant perivascular epithelioid cell tumours. Sirolimus has also been investigated for use in treating
Rapamuneis the brand name
image of different drug pills on a surface
Rapamune Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Rapamune
Sirolimus
1999
43

Approved as Treatment by the FDA

Sirolimus, also known as Rapamune, is approved by the FDA for 3 uses such as corticosteroid therapy and Organ Transplantation .
corticosteroid therapy
Used to treat corticosteroid therapy in combination with Cyclosporine
Organ Transplantation
Used to treat Transplanted Organ Rejection in combination with Cyclosporine
Kidney Transplant
Used to treat Kidney Transplantation in combination with Cyclosporine

Effectiveness

How Rapamune Affects PatientsSirolimus is a drug that helps prevent organ rejection in transplant patients, as well as having anti-fungal and anti-tumor properties. In clinical studies, sirolimus was found to reduce the risk of organ rejection in low- to moderate-immunologic risk renal transplant patients when taken orally twice daily. Even after discontinuing the drug, its effects can last up to six months. It works by blocking the body’s immune response, and has been found to be effective in treating autoimmune diseases such as lupus, arthritis, diabetes, myocarditis, and uveoretinitis
How Rapamune works in the bodySirolimus prevents cells from growing and reproducing. It does this by blocking a protein kinase called mTOR from working, which stops signals from activating the growth of cells. In addition, sirolimus can prevent the body from producing antibodies and other growth factors. It is used to treat lymphangioleiomyomatosis, a disorder that affects the lungs, in people with tuberous sclerosis complex, which is an inherited condition caused by mutations in certain genes. Sirolimus works by blocking the mTOR pathway and preventing the abnormal growth of cells that occurs with this condition.

When to interrupt dosage

The measure of Rapamune is contingent upon the recognized disorder, including Kidney Transplantation, Chronic Graft Versus Host Disease and Rejection; Transplant, Liver. The quantity of dosage fluctuates as per the approach of delivery (e.g. Tablet or Tablet, coated) featured in the table beneath.
Condition
Dosage
Administration
Tuberous Sclerosis
, 2.0 mg, 1.0 mg, 0.5 mg, 5.0 mg, 1.0 mg/mL, 5.0 mg/mL, 0.002 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for suspension - Intravenous, Intravenous, Injection, powder, lyophilized, for suspension, Gel - Topical, Topical, Gel
Renal Angiomyolipomas
, 2.0 mg, 1.0 mg, 0.5 mg, 5.0 mg, 1.0 mg/mL, 5.0 mg/mL, 0.002 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for suspension - Intravenous, Intravenous, Injection, powder, lyophilized, for suspension, Gel - Topical, Topical, Gel
Chronic Graft Versus Host Disease
, 2.0 mg, 1.0 mg, 0.5 mg, 5.0 mg, 1.0 mg/mL, 5.0 mg/mL, 0.002 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for suspension - Intravenous, Intravenous, Injection, powder, lyophilized, for suspension, Gel - Topical, Topical, Gel
Organ Transplantation
, 2.0 mg, 1.0 mg, 0.5 mg, 5.0 mg, 1.0 mg/mL, 5.0 mg/mL, 0.002 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for suspension - Intravenous, Intravenous, Injection, powder, lyophilized, for suspension, Gel - Topical, Topical, Gel
corticosteroid therapy
, 2.0 mg, 1.0 mg, 0.5 mg, 5.0 mg, 1.0 mg/mL, 5.0 mg/mL, 0.002 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for suspension - Intravenous, Intravenous, Injection, powder, lyophilized, for suspension, Gel - Topical, Topical, Gel
Kidney Transplant
, 2.0 mg, 1.0 mg, 0.5 mg, 5.0 mg, 1.0 mg/mL, 5.0 mg/mL, 0.002 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for suspension - Intravenous, Intravenous, Injection, powder, lyophilized, for suspension, Gel - Topical, Topical, Gel
Lymphangioleiomyomatosis
, 2.0 mg, 1.0 mg, 0.5 mg, 5.0 mg, 1.0 mg/mL, 5.0 mg/mL, 0.002 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for suspension - Intravenous, Intravenous, Injection, powder, lyophilized, for suspension, Gel - Topical, Topical, Gel
Chordoma
, 2.0 mg, 1.0 mg, 0.5 mg, 5.0 mg, 1.0 mg/mL, 5.0 mg/mL, 0.002 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for suspension - Intravenous, Intravenous, Injection, powder, lyophilized, for suspension, Gel - Topical, Topical, Gel

Warnings

Rapamune Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Sirolimus may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Sirolimus may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Sirolimus may interact with Pulse Frequency
There are 20 known major drug interactions with Rapamune.
Common Rapamune Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Sirolimus is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Sirolimus is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Sirolimus is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Sirolimus is combined with Acteoside.
Antilymphocyte immunoglobulin (horse)
Major
The risk or severity of adverse effects can be increased when Sirolimus is combined with Antilymphocyte immunoglobulin (horse).
Rapamune Toxicity & Overdose RiskThe lowest toxic dose of sirolimus in rats has been found to be 800 mg/kg and 2500 mg/kg in mice. Sirolimus is a drug with a small safe range, so overdoses can occur. Symptoms of an overdose may be similar to the usual side effects of sirolimus. Treatment usually involves general supportive care, since sirolimus is not likely to be removed from the blood by dialysis.
image of a doctor in a lab doing drug, clinical research

Rapamune Novel Uses: Which Conditions Have a Clinical Trial Featuring Rapamune?

80 active studies are examining the use of Rapamune in providing relief from Renal Angiomyolipomas, Lymphangioleiomyomatosis and Kidney Transplantation.
Condition
Clinical Trials
Trial Phases
Kidney Transplant
35 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 4, Phase 3
Organ Transplantation
0 Actively Recruiting
corticosteroid therapy
0 Actively Recruiting
Lymphangioleiomyomatosis
4 Actively Recruiting
Phase 1, Phase 2, Phase 3
Chordoma
0 Actively Recruiting
Chronic Graft Versus Host Disease
25 Actively Recruiting
Phase 4, Phase 1, Phase 2, Not Applicable, Phase 3, Early Phase 1
Renal Angiomyolipomas
0 Actively Recruiting
Tuberous Sclerosis
6 Actively Recruiting
Phase 3, Phase 4, Phase 2, Phase 1

Rapamune Reviews: What are patients saying about Rapamune?

5Patient Review
5/7/2010
Rapamune for Prevent Kidney Transplant Rejection
I had a liver transplant in September 2008 and was placed on Prograft and Cellcept. Unfortunately, I had a stroke in November of that year as well; luckily, my liver MDs said this was a very rare side effect. They placed me on Rapamune and I've been doing much better since then. My only issues now are high cholesterol and blood pressure, but those are being treated with medication.
5Patient Review
10/6/2015
Rapamune for Lymphangioleiomyomatosis
This has been a really great medication for me. I've had it for four years now and it's kept my lung function stable the whole time. The only downside is that I sometimes get mouth ulcers from it.
5Patient Review
3/21/2011
Rapamune for Prevent Kidney Transplant Rejection
Six months ago, I had a kidney transplant. The Rapamune and Prograf have been working well for me with no side effects at the current dosage (1 mg/day and 4mg/day respectively).
5Patient Review
9/11/2011
Rapamune for Prevent Kidney Transplant Rejection
I had a kidney transplant in April of 2009 and my son was the donor. I was on cellcept, prograf, and prednisone, but on July of 2010 I was diagnosed with central nervous system lymphoma. I had intense chemo for the last 14 months, but they switched me to 2mg.daily use of rapamune with no side effects. My cancer is in remission and the kidney is doing perfect.
5Patient Review
2/11/2012
Rapamune for Prevention of Cardiac Transplant Rejection
The only downside is that it increases your cholesterol and triglicerides, so you need to take medication for them (statins). Otherwise, the drug does great things for your kidney health.
View All Reviews
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Patient Q&A Section about rapamune

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What drug class is Rapamune?

"This medication belongs to a class of drugs that suppress the immune system. It does this by weakening the body's defenses to help the body accept a new organ as if it were the person's own."

Answered by AI

What is the drug Rapamune used for?

"After this, the corticosteroids can be tapered off by your doctor.

Rapamune is a medicine that helps to prevent the body from rejecting a newly transplanted kidney. It is most commonly used in adults who have a low to moderate risk of rejection. It is often recommended that Rapamune is used in combination with other rejection prevention medicines such as ciclosporin and corticosteroids for a period of two to three months. After this, the corticosteroids can be tapered off as decided by your doctor."

Answered by AI

What are the side effects of Rapamune?

"You may have a fever, cold symptoms such as a stuffy nose, sneezing, or a sore throat; mouth sores; nausea, stomach pain, or diarrhea; a headache, muscle aches; chest pain; dizziness; or acne."

Answered by AI

Is Rapamune the same as rapamycin?

"The medication rapamycin was originally discovered by scientists from a soil sample on Easter Island. It was later given the generic name sirolimus by the U.S. pharmaceutical world."

Answered by AI

Clinical Trials for Rapamune

Have you considered Rapamune clinical trials? We made a collection of clinical trials featuring Rapamune, we think they might fit your search criteria.
Have you considered Rapamune clinical trials? We made a collection of clinical trials featuring Rapamune, we think they might fit your search criteria.
Have you considered Rapamune clinical trials? We made a collection of clinical trials featuring Rapamune, we think they might fit your search criteria.
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